ID W6URZ1_ECHGR Unreviewed; 1128 AA.
AC W6URZ1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN ORFNames=EGR_01141 {ECO:0000313|EMBL:EUB64013.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB64013.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB64013.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB64013.1}.
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DR EMBL; APAU02000004; EUB64013.1; -; Genomic_DNA.
DR AlphaFoldDB; W6URZ1; -.
DR STRING; 6210.W6URZ1; -.
DR EnsemblMetazoa; XM_024490390.1; XP_024355209.1; GeneID_36336856.
DR OMA; WWKSGRY; -.
DR OrthoDB; 3686360at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45627; ADENYLATE CYCLASE TYPE 1; 1.
DR PANTHER; PTHR45627:SF12; ADENYLATE CYCLASE TYPE 3; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR SMART; SM00044; CYCc; 2.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 71..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 788..805
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..832
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 852..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 310..437
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 941..1085
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1128 AA; 127992 MW; 37A6DBA7339D68CC CRC64;
MSTALGGNIL GYELTDILDV AGSSARGSLL GRFHRGFADF TYILKLRSHL LNEYFERMSL
SLKKNSFRLV LFYHSLLLST TMIGMISMIP FGSYRFGGIL LYCDFFLTGL FTLLTVFNFS
ANTYAWLSIS FTSMVGLSIL IHFGTISVSL PIHNTLLSLL VFIVYTHLPV SLAFSVAFSF
LLYTGFAMLE TFTFFHDFAA PQITLALDQM DNARRVRTVS TFCFYLIIAT TCLALYLKIF
ISLRFKASFL RACQAVHMNA QQKKALVEQT VWIDAVMPKK IRVKYWQLLK QHRDVDKSLW
VFCETYDPVS ILFSEISGFT TLLDSLSASN LLFLLNSLFS KFDNLCYNCG CERIGTLGSI
YYCVSGCPSP RIDHAECCAN LALLMMDVVG GMKYERQVEL ALSVSIHTGN VNGALVGMDR
FRFDIYSYSV LTAQKLLATC PSGHIHISSE FERLLPASFK TSPAQPITVK REVQSAIAGM
KLIDVPLSTY YLDVDSERLI SVGSLRRSPE TKAVFRLEGR ANAVKDSKSY VRQTIRPRKQ
SFSWYKHIVA KKSEFAHIRS DTFTKTERPP SSMIWNVDAY QDRKFETIRE FIFGIPAENQ
DIMSQLVENK EMDVLDNEVI KEMHADSRYL SYLFNPQLLN PLTLKFRDAE IEKMYKNRNE
NQLTPVYIDS LKLAPAFDTI FLYIYILLFT AAYISATAKE YLTGILISAL SCVAAVLLAL
PGIILINYAI FKRIPEGGRI LGRFLRLGKS RIFIELVCLV IGQLPTAEIV LFLYFISPSK
LFRPKDGFIM FFAPVAILIH CLPVDSPHIV RCVSSAVSTV TLFLCILFYA KFDSIRRSEY
AWFYDASIFQ PYTLASLMSI ITAWILVVFV ARSNEATCRL RFYMVMEVER AADTTARAMR
ECDTFINNVI PMHVVRSLLA EGAQTLNINS VNHAALVPQV GIAFIRLTNF FNSYYREDYH
SGKHAIGLLN QIICMFDRRL RRPEYKDVEK LKTYNDSYMV AAGLDLRQRE QNSDQAMHLL
KLLRFCYGLF KLIKKFNEKF ILGQDNAFEL GIGVDVGPVC AGLIGSAQPY YHVIGRPADI
AYLLHLTSPP GKIAVTDNVR VALISHFHFE EAVLPNPPRV DQSYYYCV
//
