ID W6V0G5_ECHGR Unreviewed; 1413 AA.
AC W6V0G5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Proprotein convertase subtilisin/kexin type {ECO:0000313|EMBL:EUB64372.1};
GN ORFNames=EGR_00916 {ECO:0000313|EMBL:EUB64372.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB64372.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB64372.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240, ECO:0000256|RuleBase:RU003355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB64372.1}.
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DR EMBL; APAU02000003; EUB64372.1; -; Genomic_DNA.
DR STRING; 6210.W6V0G5; -.
DR EnsemblMetazoa; XM_024490165.1; XP_024355568.1; GeneID_36336631.
DR OMA; FCHATIY; -.
DR OrthoDB; 2996957at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 2.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR42884:SF23; FURIN-LIKE PROTEASE 2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00261; FU; 8.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1313..1332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 550..714
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT ACT_SITE 168
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 208
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 437
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1413 AA; 154868 MW; 7B05DC06446B4842 CRC64;
MPTTEGDCQR YTAIIRGAMT ACWAFTLMTL HLLIKCLSAD SKLVNEFVIE IAVEGNARHI
IESMGFKFIR KIHGHDYTYL AKLPEKSFEN ATKYLLRTKR NAEVVLIEQQ KQLIRTKRDV
FTWNDLKYPD MWYLNRASNK YSDEVDLNVQ EAWQLGYSGK GVVVTIMDDG LDHTHPDLSA
NYAEQASWDV NNGDRDPMPN TTNPDNKHGT RCAGQVAAVG NNSVCIVGVA FNVLIGGIRM
LDGTITDRVE AESLNFNQNY IDIYSGSWGP DDTGQIYEGP GRMASEAFHK GATTIVGEGD
LQLIRPHVLR PYHACTQGCT RGPSTGAEYA IWCNGLCLKR GHCNNASADG RNGLGNVFVW
ASGNGGRRGD SCAADGYVSS IYTLAVSSVT EHNTQPWYLE KCAAILVSTY SSGGPGESGI
VTTDLNHGCT NSHTGTSASA PLAVGIIALM LEAKCVSTSF GLPARLVPAT SLSFLFLHPW
LSSCEKATFR FRPKLTWRDV QYLTVLTANT KPFKDGDFTK NGVGYLYSNY YGFGLMDAGK
AVRLSELWRT LPPHHRCTTN VKQLSRDLSV LFSETYTFNF TGCRPFLAAD SSNGRINEEG
EPIAFVEHIQ VFMTVRYDHR GLVRVRVVSP SGTVSELMPV RLFDAFSKFD GIDRWPLMSV
QFWGEPSAGE WKIIIDNMEG FKLLSSWKKQ QEAFEKSAGQ WDSVHMVAYG TESFPIRLKP
PSKERQPPKP WFDRFAQYVV SDDEMSPTGY TCHSQCATNE CWGPSANQCL KGCKNFVTES
GQCVSECPMG TTALISAIVS DLRAQSSSTA VARGELRCER CFSACAECLR PYSAHSCTAC
SGDSYLAPFL SPTKAQVPLN PRIARLLDSI TAVHGNRLLV GSCVSRCPIG YFANETSKVC
EQCVGNCKKY SGLGADACQE CAKNYRVDTA GPHRCPKGSF LKGNICVPCV AGCNVDSCSE
HGLCTYCDTA HRFMHEGRCE KSCPVGFFPA FRLRQSGLYE TETAPIVDDA GIVWMCAPCP
PGCVSCSPSP RRLQGFVVPR CDTCHKGLSL ERNSGLCKSP CPIGTYGQNC TRTCHHMCLT
CLDELDSCLQ CSSGAYLAYG EHRLDPLIIF TSDKPIGYGC VNFCPEATYA ARIDGELICL
PCPPLCKSCA APDKCTRCEE GYALSKRDGK CEPVRSCSQA TYFDNSDQKC KPCHPSCVRC
RGSGSSDCLE CPRLSSGLST FPACLEPPPP MRATHTSQEP LLESPVGTCY PCCHVARILD
SQPPSGFTCS SWAAIGGGLG LYENYTFLGG IADTPLEANG SGWAWVGEDP VRLSFFITAI
LTVAIALGYL VYHLTTKRIR KRHIRNYHSL FLSHGRTGSR LSQRCPDAGS SPVIHIQSPV
NGQTNGRAKT PVIVSEQNSF FNQLQPPKLI DNF
//
