ID   W6V4U9_ECHGR            Unreviewed;      1182 AA.
AC   W6V4U9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Histone deacetylase 5 {ECO:0000313|EMBL:EUB61234.1};
GN   ORFNames=EGR_03909 {ECO:0000313|EMBL:EUB61234.1};
OS   Echinococcus granulosus (Hydatid tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC   Echinococcus granulosus group.
OX   NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB61234.1, ECO:0000313|Proteomes:UP000019149};
RN   [1] {ECO:0000313|EMBL:EUB61234.1, ECO:0000313|Proteomes:UP000019149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24013640; DOI=10.1038/ng.2757;
RA   Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA   Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA   Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA   Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT   "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL   Nat. Genet. 45:1168-1175(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUB61234.1}.
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DR   EMBL; APAU02000022; EUB61234.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6V4U9; -.
DR   STRING; 6210.W6V4U9; -.
DR   EnsemblMetazoa; XM_024493158.1; XP_024352430.1; GeneID_36339624.
DR   OMA; WMRARMA; -.
DR   OrthoDB; 239005at2759; -.
DR   Proteomes; UP000019149; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF15; HISTONE DEACETYLASE; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 2.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT   DOMAIN          667..892
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   DOMAIN          974..1065
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   REGION          80..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          120..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          199..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          418..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          525..551
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..144
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        531..551
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1182 AA;  124750 MW;  4CF03A419F2A4B4F CRC64;
     MYETCAFEAA PPASKLPRLK MDDITVPSAL SLHPGNGGKA ECRKRYGPVG ESRSRLAQAR
     LVLSRQASFD VGGCAADAVD TSPPNSLSMD ETDHGLQQSP RVPLESTTAA TSIRLQRANS
     SYASTTMSPS NLLSNGSPKK ISSQQVRQRL KEHLLSRRVM SVEASWSVGG GGASMDVSTA
     LAASSASPQP RISLRHFSRS FDSNRTPSSP SPPPSLSHTE TSAPRPSSPS SLPRKRAAYH
     RSTTLSLDST IKLPTTTSSV SEVALATRNN VWREGKPPAH YQQSSLGGCF VAYITGPSSY
     NPQMAHVRSD DFSKGLVGSS APAAVAVEMP LDLTTAPVAA SSGESLRRLA SDCPHQRQVP
     AAGGGASVGD ISLLMQQFEA LRNPSIKDLV PSKVGDNSPQ GTETYVGPSA YQWLGEEGDR
     RVKSRSTENT PVPKQLPVFN PISLSAPPPA ATATTAAAST TLSDLQQTAA SLVSSLTSLC
     RPQPVGGSGT PSQLNLLTTS LFHPHLSTQV SQNLHETQET LAALTLGGPQ EETVRPSTVV
     STTPATVTTT PMPTAHEFLR GALERAYDEL LRHWNGLSPV LSWPTTGSKR TGESLASNET
     ALLFDPAMLS HVCLCPHGNN PQVHPEHPLR IISVLERIAS SRLQIPRSLL SSTSVTATPN
     QEAHLALSED LPLAFFCHWM RARMATREEL ALFHTSEHIA RYCPDSSSDY GGDERAEIEG
     LGSMTELVMD AETSVKKGDR KLATSSLATL HCGGMGVDSD TVWNPETTSR SARLAVGQVL
     CLAHNLACGR LRNGFALVHP PGHHAEPDQA MGFCYFNSVA IAALSVLQSG LANRVLIVDW
     DIHHGNGTQF AADKHPGLLY ISLHRYDQGT FFPGTGSFQR HCQSGYTVNI PWGCTDISPV
     ASVRRESWRQ TKITKAASSN DSGVLEDCAP TMVGGIAQSC TSSPASSSAG SLDVGLARCS
     GSGGSGGETS GTVGLSDSEY LAAFRSLVLP LATEFAPDVV LVSAGFDAAA GHGSALGGYE
     ISPGAFAWMT RQCMSLAGGR VGLVLEGGYV ASVTADCVTT CLNALLLPNP PPAVFDVNPC
     GSCLQRLASL DDCITAAKAW VAPSELARAP RPEAVKTLVE VANVHAASGR WKCLTTPDTS
     GFVDVALSFN RAMEQERARL LSSSTTTTLS TIWGTPSNPD ST
//