ID   W6V8M7_ECHGR            Unreviewed;      1398 AA.
AC   W6V8M7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=LIM zinc-binding domain-containing protein {ECO:0000259|PROSITE:PS50023};
GN   ORFNames=EGR_02335 {ECO:0000313|EMBL:EUB62894.1};
OS   Echinococcus granulosus (Hydatid tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC   Echinococcus granulosus group.
OX   NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB62894.1, ECO:0000313|Proteomes:UP000019149};
RN   [1] {ECO:0000313|EMBL:EUB62894.1, ECO:0000313|Proteomes:UP000019149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24013640; DOI=10.1038/ng.2757;
RA   Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA   Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA   Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA   Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT   "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL   Nat. Genet. 45:1168-1175(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUB62894.1}.
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DR   EMBL; APAU02000010; EUB62894.1; -; Genomic_DNA.
DR   STRING; 6210.W6V8M7; -.
DR   EnsemblMetazoa; XM_024491584.1; XP_024354090.1; GeneID_36338050.
DR   OMA; KDETHYI; -.
DR   OrthoDB; 5399346at2759; -.
DR   Proteomes; UP000019149; Unassembled WGS sequence.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR002938; FAD-bd.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR23167:SF54; [F-ACTIN]-MONOOXYGENASE MICAL; 1.
DR   PANTHER; PTHR23167; CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED; 1.
DR   Pfam; PF01494; FAD_binding_3; 1.
DR   SMART; SM00132; LIM; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 1.
PE   4: Predicted;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW   ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023033};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT   DOMAIN          840..902
FT                   /note="LIM zinc-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50023"
FT   REGION          974..1034
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1107..1135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1154..1197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1377..1398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        993..1023
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1113..1133
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1168..1182
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1398 AA;  155330 MW;  2160551B81BB93C4 CRC64;
     MNAVNTVNYE PIENYFDKFC VSTTFEGIVT AFERLCDAAN LGSLPGSGQF YKELRRRLSF
     YWKAEALFTI LDVRFGERIY GGQTICRNIQ VLVVGCGPCG LRCAIELALL GANVVIIDKR
     TSFSRNNVLH LWPYLISDLK SLGAKSFFGK FCAGSIDHIS IRTLQCILLK VALLFGVQVV
     SGVEFHKLIQ PSDDTEESDV CSGENGSKTP RCRGERPLRD LFTLYEGKRR ARYGWRVEVA
     PSHEALSTFE FNAIIDATGK SSCCLNFPRR ALRCRLAIAI TMNFINYGYV EEAHVEEISG
     VGSIFNQPYF AQISKTLGIE LENLVYYKDE THYIVMTIKK RSLLTKGVLI KDLEDPVKLL
     SAENVNFSAL EQLAREVATF VTRGGLRRLD FALNSRGQPD VAVFDFTSLS AAQYACRVVD
     RKGRPLCQCL VGDALLEPFW PRGSGCALGF LSALDAAWTV SLFAAGHHAL RVIAWRDSVY
     QRLSQTSPSN MPPNFAAYSF LPTARYTCID LELVRPMQVR HLYDSDVTAN MTERKSFAFL
     RDSVKFDDPD IIPTATISAA KQNDCSFKPT FSPHISLLKW YQQRLSPYPD TLCPPIIDLS
     AETWADGRAL RCLLHKYRSD LVSEEALKME VAMGVGEVVR LLAEYFGAPS TLVDTTWLQY
     LDVLHDCLKD HDPAFVANMT VRGQLVAKNG VQQHSFVVAS SSDSIRPFNR CIDPLASPRV
     SSRTRPLLSP RVECRRVNVP MLQRSLENPM ARAEPPSTLR AREDASSAVK KGLMAKRRSD
     LIAMLNDPAS ARRRSLLIDW ERAFEEGGLQ PLPSPPRCLL PPRDHQSSNG AASFREKSRD
     FCAVCKKPLY AAESRAYDGF RLHPNCFRCV ECHRTLRPDI AHCLRHQTNL GVRAHTLVSC
     TRAQGWRNTH HSEARVACDA GADVRAAACF ASSLILSSQT LLCSRSPSRS LCRLAKFYCT
     AHFHPALTIA EATTSGSRIS TRKPVLPKPR AHNTPSLFSQ LANPASPPGL RWHSSNNSPM
     TTEGVERAKP GASAELRRRS AARGIRDEPA PPILLTSRNV PGTLGLPECV RRAAFDERLY
     RLNGCPSPDD FISNRTSRIL DEEEDCFASS ENELSDRGLT TSNITSTASE SPPMSLDEAK
     HLCCIMREKN LYRRHHPSTG SSSGSREEEE EKEDDDDDSM SDEDSKLVNM DTFDTPQPIS
     EYENVRWTLV RPPPSPVSSV ATNAIGAVSS TSAAEPSLLV RKYGLSGSML LAKQRFCMAD
     PEPIHIDPRA FRATRNKERT IETTLPDCTE QVEFLPDANL TSLPLAEVGH PSVDGIDFSL
     TYGLVKVIPP HSSSTQLNVA LHTDPVEPLP SLVSANLQEL SVHEVLNRSD AVVHHAFSST
     SRNNHHQRHP TPHSVRGH
//