ID W6Z917_COCMI Unreviewed; 323 AA.
AC W6Z917;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=COCMIDRAFT_99274 {ECO:0000313|EMBL:EUC44054.1};
OS Bipolaris oryzae ATCC 44560.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=930090 {ECO:0000313|EMBL:EUC44054.1};
RN [1] {ECO:0000313|EMBL:EUC44054.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 44560 {ECO:0000313|EMBL:EUC44054.1};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
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DR EMBL; KI964013; EUC44054.1; -; Genomic_DNA.
DR RefSeq; XP_007689463.1; XM_007691273.1.
DR AlphaFoldDB; W6Z917; -.
DR STRING; 930090.W6Z917; -.
DR GeneID; 19129434; -.
DR KEGG; bor:COCMIDRAFT_99274; -.
DR eggNOG; KOG0409; Eukaryota.
DR HOGENOM; CLU_035117_6_1_1; -.
DR OrthoDB; 203032at2759; -.
DR Proteomes; UP000054032; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR22981:SF81; DEHYDROGENASE, PUTATIVE-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 10..178
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 184..308
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 188
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 323 AA; 34559 MW; 8263B533C346B041 CRC64;
MPQPYEFSRL GFIGLGAMGT PMLSHLARKL PEDSLIWVYD VVEQAVDDVC AEFPNRVLKG
KNAKDVAQQA DTIITMVPEG AHIRSVYLDP ANGVCSTDVS NKLLIDCSTI DTATSLAVKE
HVTNHFPSAA FYDAPVSGGV VGAIKGTIAF FLGCGESDAN MGRLTYLLSL MGGQVIPCGG
PSLGLAAKLS NNYLSGIIAI ACSEAFDMGM RSGLDPRTLA KVYAAGTAQN AICDKFCPVP
HVYPEAPSSG GWKQGFKVQL MRKDFGLAVD MAKRVGSRNV LGEVGFKTYD EAANDPRCRD
LDSRVVYRYL GGQEDWQAKS NGT
//
