ID W7AWR2_PLAVN Unreviewed; 469 AA.
AC W7AWR2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=rRNA (Cytosine-C(5))-methyltransferase, putative {ECO:0000313|EMBL:CAD2112235.1};
GN ORFNames=PVPCR_1305460 {ECO:0000313|EMBL:CAD2112235.1}, YYG_04928
GN {ECO:0000313|EMBL:EUD69866.1};
OS Plasmodium vinckei petteri.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX NCBI_TaxID=138298 {ECO:0000313|EMBL:EUD69866.1, ECO:0000313|Proteomes:UP000030659};
RN [1] {ECO:0000313|EMBL:EUD69866.1, ECO:0000313|Proteomes:UP000030659}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR {ECO:0000313|EMBL:EUD69866.1,
RC ECO:0000313|Proteomes:UP000030659};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium vinckei petteri CR.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAD2112235.1, ECO:0000313|Proteomes:UP000515268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Ramaprasad A.;
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR EMBL; LR865418; CAD2112235.1; -; Genomic_DNA.
DR EMBL; KI965409; EUD69866.1; -; Genomic_DNA.
DR AlphaFoldDB; W7AWR2; -.
DR EnsemblProtists; EUD69866; EUD69866; YYG_04928.
DR VEuPathDB; PlasmoDB:PVPCR_1305460; -.
DR eggNOG; KOG2360; Eukaryota.
DR OrthoDB; 240101at2759; -.
DR Proteomes; UP000030659; Unassembled WGS sequence.
DR Proteomes; UP000515268; Chromosome PVPCR_13.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22807:SF30; 28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 99..469
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT ACT_SITE 404
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 221
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 261
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 309
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 469 AA; 54861 MW; 67CBD2F87DDEEA9F CRC64;
MSFIYRKAAQ MLMKCSKGDG IKDVLFKKED QSIKKIYFIV HKSMEDLDIF NKIYNTHLSK
ICKNKYLGIV LLCVLIHRKK IDGGGELKRE ILKKEKEIFK LYNNLKNNND VKINILTKYF
IIYLNDNPNI VNEIKTLLPI ENDEDVENLY KICTSKVKNL IDSIYYKNNK IRILDKSSGL
VVKSANIQKG MTIVDVCSSP GSKAILSLLN LENKGYLICI EKSKTRCYTL IREILKNDEY
IGYYTNENMN ETDKINIDKK DLFINNENNI YYIKHKNNEL IIKIYNCDFL KLTHKDFQEI
GDIDVVFVDP SCSSSGMPDF VHKENMRKVF LQTKQIENDK NKKNEEDEKY NSYNIYSDIS
EERIPKVPNT LIDKIKNLSN FQKDILNHAL ITIKTAKTFI YSTCSFFEEE NEQVIKNVLE
KNLEFSIENA GTDKFLFKNG KYAFSDKCVR TFPNRDNCRG IFICKMCRK
//
