ID W7FN65_PLAFA Unreviewed; 2095 AA.
AC W7FN65;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Histone deacetylase domain-containing protein {ECO:0000259|Pfam:PF00850};
GN ORFNames=PFAG_05828 {ECO:0000313|EMBL:EUT79259.1};
OS Plasmodium falciparum Santa Lucia.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=478859 {ECO:0000313|EMBL:EUT79259.1};
RN [1] {ECO:0000313|EMBL:EUT79259.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Santa Lucia {ECO:0000313|EMBL:EUT79259.1};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Santa Lucia.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE123511; EUT79259.1; -; Genomic_DNA.
DR EnsemblProtists; EUT79259; EUT79259; PFAG_05828.
DR Proteomes; UP000030666; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF4; HISTONE DEACETYLASE 6, ISOFORM G; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1401..1740
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 388..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 467..494
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1765..1844
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 664..704
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2095 AA; 250627 MW; 57C120F0E29CF380 CRC64;
MDIVKDERNI RYEYELDKIK KKKKDNLLIM NILYNKINYI CYILKSNHRD ILNDINFENR
TAIEICLYYC KSYILFLLLF YPYLHNYIRI LKNNDLRLYK NFYKYILKRR NNLHILLLKY
RILECMKLKD KDVNDSNTIS YIDVYSMNRY MNDEDDIDKY YYKPKFSYKN NNMNNLLLLN
VYFKDIMSKN NFICILFSRI YIKKYHKKIF RILLLILFYF SLPTFPFSKK FFITYHNWRD
TEKDKIKEEN EENHTNTKGI NNSTYDNIYR SVLEDKVEGK LIEHNKNISK NNVGVQAVQE
GVVYGTEEIL KNENKGTGGM QGNNIKKKKD RGKKKDMDED FSFYCKRKYF TTPFFEHINI
PTIHINDYFC SGNKIFEREE FKVINEKKNK KKKDNTNKYE SNYDSKYDNN NSRDHYNNFR
TYEENNIYNS DSSSSVSSSL SDDILSDIED ENMLKELFKN ENKIYSKEES KKNDNEKERN
IKNLMKEKQN ILNEKLKDID TNYSKSTLND MKNDFFQMNI KEYDWYDDNN IIRRVYRKED
DIIDNFTLKK EPFVSELWIN VINFNVEDDN KNTLIHKACL VGNLNIIYIL LYLNVDLFIY
NYKSELPVHC TIYNCDKYIF LLLLHNTIEC IFYVLLEEYK RWNKTHNMLN TKTESEKMKI
QNRKNKLKEK KKNKKKNKNK KNKNKKNKNK KKINKSRINY NNKKKNNKKN NQNVQNVQNV
QNVQNVQNVQ NVQNVQNVQN VQNAQNVQNV QNAQNNIDSF NSSEKHDEDI EEVNEMYKKY
IKDGKFFYYK NINDKFLYNV IQLYLSVIVK IIELGNFEFL KILFNYNSSI FSYIFLNKNM
FSFLCSIACM YNCLNVFIFY CGNIIKWSVF ETYVEEQKLN FLERTKKRKN VSTYGTNNND
ENQYNFYDMN NEKKRNEFQN NNLFQTGPCS SIKKNKTNLD TSKDTSCFIN SYEKIEDVHQ
QDFFNILKCV PYIINNGRMS GIGNNMDQNN MYNQNNMYYP NNMCNPNYLY NDNNNNLCNN
MLYHYFKINN MVNHRFLNIS NISFYDPHVN AILTCRAKDP IGTFCEMLYK KDNKRLIKND
IVKKCINKNN SIKIFFSKEC FKHIFVPEPC DHPYERNKLK NNIPENSTRL DVLISNKHGI
LNINTFAKFK VKCVDRKATV NDILRVHDVS YLKFIINKIK NFKMSDDDLM YFDDFLTKAK
KNFKNYLLTN NGNENTGNQN NPIQKNEILQ TFYLINKKSE LENIMLIRMN NKFMGNRDLY
IQNYLSNIHT PMHANLKDKP LVSLELKKIL SDSDSEDNNN NDIENYEPEK YVYMENGIRM
NILTDEGLTE AANVLYINNS ILYNNNIFFN NNLLYNNNIL MSEKNTDYPF FHNEDIVGTN
KSATNLLIQE KLSSYNINVR EKKKKKNKWN KDKIEKLLLV DNDTFVNKYS FNCALSASGV
VLKAVDYVHK QKKIVNCGYE KLKKCKKCKY CKKCENCKKC KNSETCKNCK NCKKCEYCKK
CKKYRIQNNS IIPNNRKKIF CVVRPPGHHL GTFGAAQFNL TDEDVAAGSQ GFCILNNVAV
GLAYAKYTYK KFERIAIIDF DVHHGNGTEQ IIRNLGLKKL TVNEYIDIYS WKGWKDNNDK
KNIFFSSVHA YDGYFYPGTG YDTVELEPYI INVTLKKNMT SLEFLNIFHS KILIHLYYFK
PNLLFLSAGF DGHQLDYVNN GFVKKNTSTY FYLTKLVLSL QNKLNFPIIS VLEGGYNTSK
DMASVFSLSV LEHVLSFYYN DISFFRKKEI KLKDLKKNIE RMERYKNDLK KYKNDLKKYK
DDLKVFEDYL KENKNLFENY KNDLKKHRND FKKHKNDLKI FKDDFKKYKD DFKIYCDFNN
YYDLKKSCNY FSIYYDDFNK YYDNLNVHEH TNNNQTTLQS NTDKNNTSIE TCNTNIIDKM
KNKIKKSEKE NKKIKETPTL YYPFICIGKK KIINMFERYF SVFKEKTEET QNLNLFYKLV
EYNNFLKIYD LRNIDMKNKM NKFMQTHEAV LKNILLECNY DYSKIDPIIL PSNCYFYELL
NYLKIKGISM KPKTPTKLEK KFFSAINNPY DFNKIDLENC KRHPKKNFEF INFWN
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