ID W7FQM0_PLAFA Unreviewed; 2159 AA.
AC W7FQM0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Myosin C {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFAG_04552 {ECO:0000313|EMBL:EUT81339.1};
OS Plasmodium falciparum Santa Lucia.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=478859 {ECO:0000313|EMBL:EUT81339.1};
RN [1] {ECO:0000313|EMBL:EUT81339.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Santa Lucia {ECO:0000313|EMBL:EUT81339.1};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Santa Lucia.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; KE123508; EUT81339.1; -; Genomic_DNA.
DR EnsemblProtists; EUT81339; EUT81339; PFAG_04552.
DR Proteomes; UP000030666; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd14888; MYSc_Myo27; 1.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF706; MYOSIN-11; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00400; WD40; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 8..57
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 67..831
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REPEAT 1894..1935
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 695..717
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1181..1237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1588..1616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1662..1698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1068..1123
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1258..1292
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1181..1214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1588..1602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1681..1698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 160..167
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2159 AA; 250142 MW; 1244937E952DE1E3 CRC64;
MEGANKCVIG TKIFIRDKNK VWASAEIINE DEDNIIVKTE DDDIIKLKET DEFYLRNLDL
FDSSGLSAPS DLTKLTHLHE ASILHSLNLR FDIDEIYTFT GPILIAVNPF KIIKDLYSDN
MLAKHVQPIK SKSPHIFATS NSAYLGMCNN NKSQTILISG ESGAGKTEST KYVMKFLACA
GSDIKKRSLI ESQVLESNPL LEAFGNARTL RNNNSSRFGK YIELQFSVDH KNYIKGKLCG
AKILTYLLEK VRVCDQQEGE RNYHIFYQLC KAVKEANIVD NSIMSNNEND DVENYVNYKC
DEDKNKDHIE NNICEEPTQK KKKWYHFPST SKFRNLENVE PMKIDFTDFK EHVHFRYLTK
SSVYELNEVN ELEEFESTVH AMQTIGISNT EQYQIFKILE GILYIGNILF NNDETKEEAT
ILEVSNDDLR KAAYFLDIDE NDLINSLCYK TIVANNEHYK KPVNSNVAND IRDALSRAIY
GCLFLKVVER TNESIGYIKD INLFCGVLDI FGFESFPVNS FEQLCINYTN ECLQQFFNNF
IFKCEEKLYM EEGIRWDPLD FPDNKDCIDI LESKPYGVFC MLDEECYIPS GRDKSFCSKI
ISKHTSSSNN NQSNKRFKSI KTDSSSFIIV HFAGQVVYNS TGFLEKNKDQ LSLDAQKLLL
HSKNTYVSHL FETYLRRNTD KRKFVTVSSE FKEQLNLLMT RIKETEPHFI RCIKPNAQNV
PDVFDRISVN EQLKYGGVLQ AIKVSRAGYP VRLSHAECVQ DYKILLNKED RHKLEMYNKD
NKSWSYKANF ILSSLYVTKE IQEYINNLKL LKDKKKEEEN KFFGKLSSKK NKKMQDTTTT
MNEVSNNVQI NNKDETNNNN NNMKDIVYDP VCGDANEEEE KNNLFIWSVG KNLCFFKSDA
YNILSTLRSD LRSLKAIVIQ KNYKTYTQKK LYELMKRKII IIQRWFRNRL NIIRKEKLKR
QEAEKLICSY IYTYIIRKRF LHKRNCCILI QSHIRRYLMV RFYKTYRQNY YASKIQATWK
AYKEHLFYKK LLKSTKKIQL KWKSILARKQ LRRLKMESKE VGSLLSRNQV LMKELKKEKN
EKIEIESKLL KASAKIDKLI KKIDNLEKDN KNNEKVIKDL LEKVSLLSYK QSNECISPRH
VSKKNENIKQ KKNNKELNKD IIMSLKREDT EHVDSMEIMS IQGNNTHDDP NNVRNSYSTD
TNLTNYLNNN KSNNNKDHNN DHNNNNNDDG DGEDIYMDNN LTFTQEKIGD LKIRNTIRNE
KNEEKYNLLN KIKKLEIQNK EYIKQNVTLN DKYNKLVSLL GQIKDTNNNV YNDVLINNIN
NYHSNGMSNK LLLNNYNNYH NNNNNNNNFF KNLTNLSSCN SNSLIEPKIE NNINYDNKSS
FKKNDGIVDI LVCGPRNVGK TSLLEDLFVR LGDEDNLGLL RKNKKLVNND LSCYNYYNTY
IITHKCSQIK IVDCGYSSNK NVEESLFNYI KNSICIIVVF DATNKESINP AVHLLQEASL
INVKKTTKLY LFENIFNEKI NLNFNKNDVS YAVRVSKACN ASYVKALDIY DIVNNYANKI
TLHSNYFLDN THNNCNYNNN YNYNYNHVTS VPPNQHSEHN NNNYYHNNKE KDNDKDKDKD
IYVKGLAHLN HMNKSKRNTH SYMSSYHEES LKDSDDAALS SFGNKSNDLI KSKRGDIGKN
KYNNNNKNNN SSNNNNNNIY SVVNTLKAIC GIQNSNKKNQ QIQLLRESMP LNNYIYGNKK
YNSDLGKGLQ PVYEITLKGN IPITYLCMGQ DNINKNYTLL SVGCKDGVIY IYKCFRTSLE
LKNDYFYYYN DDSSMYNMNN NMDKNVNNVY NNMDKNMNSN TTLNIQNNDN NNNNNNNVGC
DDNVKKSSSI LSLKNDSNKT YDESSTCTKL LSKLSGHKKA ITCLVFSFSE DKIISSSIDR
TIKIWEVSSG FLLKVFSDSS ATLSVLLFPT NLDIFLCSNC TSLLRIVNLN SGQVYQKIKV
ESEIRALEMD DTCLNIFAGS KNGTIYVLEV IYNERVEIKF RFLFSLSPIT CIKFIPRHSV
KTSPAIIVNS CDNHIGIIEC VYGNKGILTT LYVKHRIRIN HALLPIRNCY SRFGGGWVMS
GSEDGNIYIC SLLPQSNYKL IFLKHHKAPV MAVVVNNIDT LMVSGDSKGN IVFWRRSFV
//
