ID W7I256_9PEZI Unreviewed; 1290 AA.
AC W7I256;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=HECT domain-containing protein {ECO:0000259|PROSITE:PS50237};
GN ORFNames=DRE_04326 {ECO:0000313|EMBL:EWC46383.1};
OS Drechslerella stenobrocha 248.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Orbiliomycetes;
OC Orbiliales; Orbiliaceae; Drechslerella.
OX NCBI_TaxID=1043628 {ECO:0000313|EMBL:EWC46383.1, ECO:0000313|Proteomes:UP000024837};
RN [1] {ECO:0000313|EMBL:EWC46383.1, ECO:0000313|Proteomes:UP000024837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=248 {ECO:0000313|EMBL:EWC46383.1,
RC ECO:0000313|Proteomes:UP000024837};
RA Liu X., Zhang W., Liu K.;
RT "Drechslerella stenobrocha genome reveals carnivorous origination and
RT mechanical trapping mechanism of predatory fungi.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI966418; EWC46383.1; -; Genomic_DNA.
DR HOGENOM; CLU_001858_0_0_1; -.
DR Proteomes; UP000024837; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 2.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 2.
DR Gene3D; 6.10.130.10; Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL); 1.
DR InterPro; IPR032353; AZUL.
DR InterPro; IPR042556; AZUL_sf.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700:SF8; HECT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF16558; AZUL; 1.
DR Pfam; PF00632; HECT; 2.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000024837};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 804..1290
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 227..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1026..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1258
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1290 AA; 143391 MW; 78EE886ED56010C5 CRC64;
MFTTSAATGS SSLLTHRPQA YQYSTLPPHA PPLIAQNTTT IHDPSAIASF SHAQRHREFN
ALVKKYVHQL LHGCRRPICT TPTCATCRQQ LNSPAASKGP APSPLGSRRE FTPLSARIIA
CQLATADQPY RALCPGLETD VKGRTELGCE NRGKVDVGMR DSKSFMQGLF NTTAIRSLEM
NVLPPPMDVV KVLGGTAADV REDLSDEADL AFNPKNRVVS AALSRLESEA RKDYSSSTPT
KNAGGGGGDV NVPVTPNAAS VTNSMEKDRN PPVTPYHTRP SFQVSQQSTK SRRKLSHDLS
SYLTSPKNTF FTPDVNELTP PHVHRQHPRD ITQRRSPDTT PSRTSKLSAL DGKSINSTAT
STPLSTKSTV PLPQAVTHFT LDIISVLVAM MDDTAVSARA RLDAVRFLRQ SCYYVFGSPD
TLAACFPEDF QADKSVLVLR SVKMLFDRGM GGEIVDALWK ALGELFPTVE EVLVGNEKKK
AVRPSKYTAG TATKVFVITL HVIAAACPVA TPEVWERCRK DRSAGTVCLD IPFEDEGLLR
LVARFSRCWS AYGMFEHRAR NAVREYLLNY AKLEKKARVD KLERELGREL AGDVANSGVG
KGGWGLVVCA LEWMRAMMLK EWDGSERPRT GGVVDASILF LRFLYEDHEA LGLEESYFHN
QVLADRLEYK DMPVKWYLRK QKSAAKSANL AETPSETAAA AESQQRRPEP PHLLNHAFLL
PPIALVKFFR SINFYRMSAA YDNALAMYRF VNQMADVTRL DLFKPWLRNF IMKSYDISMT
VYLLFEVHRT TIIKDTLDQL LGREPRECLR PLKVRFLDVG EEGVDHGGVQ QEYFRLLWEE
ATKGEYGCFT TDERTRTSWF SILTLEPMHK FELLGLLVGL AVYNGVTLPV SFPLVVYRKL
LGWKVELDDL SDGWPELVKG MRQLLQWNDG DVGDVFVRSY EFGYEAYGEV HSVDLMKVGR
EDRWAPVTIE RAIVFSSSST WQRGPHGASQ APPQLTIAAL AGTSATSSEG DEPFSSAIPL
ENQLRVPDVA GSPGSSSDSS SGRILTPGIL TPESASPSLS PSRRNSAVVI DENDEAAATW
KAYDQQQQSL SSAHSTCSST MPAKITSERF IKPEGEESEL VTNANREQYV KDYVFWLTDK
SIRPQFEAFE KGFHAVLDRS SLSLFNPMTL RHLVEGSKDI DIAALEAAAK YDDGYHPNHR
CVKDFWAIVR TYDNDQRRAL LEFVTASDRV PVSGISSVMF VIQRNGGDSE RVPTSLTCFG
RLLLPEYSGR KKMREKLRVA LENGRGFGVP
//
