ID W7ISG9_9PSEU Unreviewed; 258 AA.
AC W7ISG9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=HTH-type transcriptional activator tipA {ECO:0000313|EMBL:EWC63298.1};
GN ORFNames=UO65_1296 {ECO:0000313|EMBL:EWC63298.1};
OS Actinokineospora spheciospongiae.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=909613 {ECO:0000313|EMBL:EWC63298.1, ECO:0000313|Proteomes:UP000019277};
RN [1] {ECO:0000313|EMBL:EWC63298.1, ECO:0000313|Proteomes:UP000019277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EG49 {ECO:0000313|EMBL:EWC63298.1,
RC ECO:0000313|Proteomes:UP000019277};
RX PubMed=24604655;
RA Harjes J., Ryu T., Abdelmohsen U.R., Moitinho-Silva L., Horn H., Ravasi T.,
RA Hentschel U.;
RT "Draft Genome Sequence of the Antitrypanosomally Active Sponge-Associated
RT Bacterium Actinokineospora sp. Strain EG49.";
RL Genome Announc. 2:e00160-14(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWC63298.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYXG01000048; EWC63298.1; -; Genomic_DNA.
DR AlphaFoldDB; W7ISG9; -.
DR STRING; 909613.UO65_1296; -.
DR PATRIC; fig|909613.9.peg.1311; -.
DR eggNOG; COG0789; Bacteria.
DR Proteomes; UP000019277; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd01106; HTH_TipAL-Mta; 1.
DR Gene3D; 1.10.1660.10; -; 1.
DR Gene3D; 1.10.490.50; Antibiotic binding domain of TipA-like multidrug resistance regulators; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR InterPro; IPR047057; MerR_fam.
DR InterPro; IPR036244; TipA-like_antibiotic-bd.
DR InterPro; IPR012925; TipAS_dom.
DR PANTHER; PTHR30204:SF90; HTH-TYPE TRANSCRIPTIONAL ACTIVATOR TIPA; 1.
DR PANTHER; PTHR30204; REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR; 1.
DR Pfam; PF00376; MerR; 1.
DR Pfam; PF07739; TipAS; 1.
DR PRINTS; PR00040; HTHMERR.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF89082; Antibiotic binding domain of TipA-like multidrug resistance regulators; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR PROSITE; PS00552; HTH_MERR_1; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000019277};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 5..74
FT /note="HTH merR-type"
FT /evidence="ECO:0000259|PROSITE:PS50937"
SQ SEQUENCE 258 AA; 29243 MW; 9E21AC1F9BE3B9D8 CRC64;
MEMEEHTVGA VAALTGVSVR TLHHYDEIGL LEPNDRSPAG YRLYSADDLR RLQRILFYRE
LDLDLGTIGA VLAEPGVTDE DLLRAQRELL GERIARHQAM MAVIDREVAA RKLGLTLTPQ
ERLEVFGSTR LEDNADRAEQ RWGGTEQWRQ RRRRASAHSA PDWLAIRAEQ SGIHQRLLDA
MRAGVPATSP TAADLAEEQR LHLHRWFHDC DHDTHRHLAA TYLANERIGR NYDDMAPGLS
RYVHDAIIVN ADRATTPP
//
