ID W7JM52_PLAFO Unreviewed; 1234 AA.
AC W7JM52;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN ORFNames=PFNF54_05602 {ECO:0000313|EMBL:EWC85938.1};
OS Plasmodium falciparum (isolate NF54).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC85938.1, ECO:0000313|Proteomes:UP000030673};
RN [1] {ECO:0000313|EMBL:EWC85938.1, ECO:0000313|Proteomes:UP000030673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:EWC85938.1,
RC ECO:0000313|Proteomes:UP000030673};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF54.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PLPL family.
CC {ECO:0000256|ARBA:ARBA00006104}.
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DR EMBL; KE123882; EWC85938.1; -; Genomic_DNA.
DR AlphaFoldDB; W7JM52; -.
DR EnsemblProtists; EWC85938; EWC85938; PFNF54_05602.
DR OMA; WGNTALF; -.
DR Proteomes; UP000030673; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR PANTHER; PTHR14226:SF66; TRIACYLGLYCEROL LIPASE PTL2; 1.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030673};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 580..776
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 84..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..955
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1030
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1234 AA; 144294 MW; C04605FFDE48B109 CRC64;
MKTPEFSLDS LKNNRKKKSK KLNYENWSAH YFLKLPIFVI LMIVFSLNAF IYLLIRFFIY
FFENTSFWMI TKYKDFHFFV RKKRNGKTPS SSSSSSSNKR KYNDNINNDD EPILNKNEKD
DSIFQIEHLM NTCNNYDDYI KYAYSMDVLT GKTVHINEND DYINIYDVHL LKKTSESIQT
NLLNKDILLL LEDIKIATSP RIKGIFQEKY YCKTYSIPHL IVTEFINNVM NGLNFLENYI
EQQKQININY KFSDEYLVIK KYFKDIFRQW GNTALFLSGG AILGLHHFGV LEVFLKSSIN
ADYFNHYAKK LTTQKKIKEE MLPRNSHGND ISNDINKKDI HKDSQDKKKK YIILKSNSNN
EKKLSSGDSD KKKQNKKKYI NRIKQGIKKN IQDNQKEYYD YNNNNGDDYN NNRDDNKNNF
DNYNNNCDNY YNNFDNYNNN FDNYNNNFDN YNNNFDNYNN NCGDHNDFHY DNSSSSNTSV
YHSSICEDIN LFCTDPMIKL KQHNNIKDKK KKSIMNFNIL CNNITNRNGS SNINNNKVPI
KQDGNLKFNK KDINMNPDNL KEKQKNLLFD SLNKIYKDSE QPNKNGNFPL TKNNENDFVE
NFEDNILPQI ICGTSAGSIV AAWICTRTNN ELLDEFNINF IYNIVSCFSS ENWFYSFFNI
YKKGNFYDID KIVKLIYNLY GDMTFLEAFI KTNLVLNITV TRAECENNNF SCDEDGHIVL
NYMNSPNVLI YTAVLASCSF PYLLQPFKLL EKKYNKENVY RFMSIKEVNN SKLILNSNTL
YKNRILLKED SDGLALSRSL ESSDIKSEKT CNNHDTWKHN YSNSNHYFNS NINLDDEQKN
LNEPQQAISN NVHNYENKNS SCATIDTCMK EEYILSKTIL ENEFINKPIN NNINKDYMQN
NGEVEFIGKK NHHILSKNNI KNNDNETIAS FFVSNNDLNS TGEKSKKKKK IINNNNDDHN
NTMDFQDSLV VHKGDKNDLL VLREEKKKKD NINKNDMNDY NTCDDNCDVN DDDDDDDDDD
DDDDELEDQD DICINRVLGN EIDGGDILDK EKIKKKKKNN KDTVSIEKKG TVLTDNWENE
NMLIEKTYEN GNLSNKYIDI NEYRNINLLN EEYTIINSVQ FKNMYFHDGS LKSDIPAHNL
NQILSVKYKI VSQVNPHVFP FTGVRVHGEA GKPVKWRGSS GNWRAGFLMS SMEILFKENM
RYILRLMALL DLSPTIRGLN AGSIAMQVNI KDDF
//
