ID   W7JUV2_PLAFO            Unreviewed;       749 AA.
AC   W7JUV2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00012838};
DE            EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
GN   ORFNames=PFNF54_02745 {ECO:0000313|EMBL:EWC88426.1};
OS   Plasmodium falciparum (isolate NF54).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC88426.1, ECO:0000313|Proteomes:UP000030673};
RN   [1] {ECO:0000313|EMBL:EWC88426.1, ECO:0000313|Proteomes:UP000030673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF54 {ECO:0000313|EMBL:EWC88426.1,
RC   ECO:0000313|Proteomes:UP000030673};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum NF54.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|RuleBase:RU363039}.
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DR   EMBL; KE123814; EWC88426.1; -; Genomic_DNA.
DR   AlphaFoldDB; W7JUV2; -.
DR   SMR; W7JUV2; -.
DR   EnsemblProtists; EWC88426; EWC88426; PFNF54_02745.
DR   VEuPathDB; PlasmoDB:PfNF54_100010200; -.
DR   OMA; NMFLPDR; -.
DR   Proteomes; UP000030673; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR   Gene3D; 2.170.220.10; -; 1.
DR   Gene3D; 3.40.50.620; HUPs; 2.
DR   InterPro; IPR023457; Met-tRNA_synth_2.
DR   InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR   InterPro; IPR033911; MetRS_core.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   PANTHER; PTHR43326:SF1; METHIONINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43326; METHIONYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF09334; tRNA-synt_1g; 2.
DR   PRINTS; PR01041; TRNASYNTHMET.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363039};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363039};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363039};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030673};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          145..283
FT                   /note="Methionyl/Leucyl tRNA synthetase"
FT                   /evidence="ECO:0000259|Pfam:PF09334"
FT   DOMAIN          488..606
FT                   /note="Methionyl/Leucyl tRNA synthetase"
FT                   /evidence="ECO:0000259|Pfam:PF09334"
FT   REGION          389..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   749 AA;  89307 MW;  AD5373EB957EED3A CRC64;
     MKIYFIFILF LYLNFFILII EILSKDIIKT RRSFPSYIKD GEKRKSNKIK RKRIKNDAYI
     NVYRKNILDS INIKGDQNKI KEKWLQNLKK KKAFDKISVR LSNYNDDKKE IFDITFVNNK
     EDRNDDNYDN KSCIKKVCNA EEYLLISTPV YYSNDRPHIG HAYCNILCDV LYKYEKLKGV
     EKKKKGIIFF SGMDEHGLKI EKKCNKNKMK IIEYIDDISN YYKDMNKKLS VDVNLFYRTS
     YSFHKMFVQN VWKYLVHNNY IYKDTYKGYY NINEERYISE QELREGKYKI DNENIIYVEE
     ENSYFFNILK FKDYLIDFYE KNENFIYPPY LRKQVIYTLK NELRNICISR YNTKWAIQIP
     NEAEGTIYVW FDALLSYVSS MLYLHKIKKN NNNNNNNNNK NNNNNNNKNN NNKNNKNNNN
     VINCTNGTKD VNISSTCDTD SPICSYDDIL NIVNLNANNN NTQSNILPHI SSNICDEKKN
     EKREKNIPFN KVIGKKFWNP FIQVIGKDIL NFHAILYICL LKSLNLELPQ KILCHGLIKN
     ENIKMSKSLN NVVNPFDLLK KYNPDVLRLY FMGCGSIYED KNYKEQNIES FELFLRNNVG
     NLLYRVVSLC IENNYNMVPV IKTNDYDSNI ILNEWKDNIK NKLIPYLDNM EYIQFLELIM
     TLIKNVNKFF VHNTPWNYKK DTQHFHTTIY VTLECMKYFS ILMFPFIPNI SLAILRNIGF
     DDIDEENISL DMLETRTTKF MLNGLIKIV
//