ID W7JW33_PLAFO Unreviewed; 1172 AA.
AC W7JW33;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=26S proteasome regulatory subunit RPN2 {ECO:0000313|EMBL:KAF4328917.1};
GN ORFNames=CK202_0636 {ECO:0000313|EMBL:PKC49896.1}, CYL21_2060
GN {ECO:0000313|EMBL:KAF4328917.1}, PFNF54_05781
GN {ECO:0000313|EMBL:EWC85304.1};
OS Plasmodium falciparum (isolate NF54).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC85304.1, ECO:0000313|Proteomes:UP000030673};
RN [1] {ECO:0000313|EMBL:EWC85304.1, ECO:0000313|Proteomes:UP000030673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:EWC85304.1,
RC ECO:0000313|Proteomes:UP000030673};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF54.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PKC49896.1, ECO:0000313|Proteomes:UP000232684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:PKC49896.1};
RA Bryant J.M., Baumgarten S., Scheidig-Benatar C., Scherf A.;
RT "Plasmodium falciparum NF54 genome assembly.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF4328917.1, ECO:0000313|Proteomes:UP000754359}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:KAF4328917.1};
RA Baumgarten S., Treeck M., Scherf A.;
RT "Genome assembly of Plasmodium falciparum NF54 DiCre.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
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DR EMBL; KE123891; EWC85304.1; -; Genomic_DNA.
DR EMBL; QFXU01000012; KAF4328917.1; -; Genomic_DNA.
DR EMBL; NYMT01000001; PKC49896.1; -; Genomic_DNA.
DR AlphaFoldDB; W7JW33; -.
DR SMR; W7JW33; -.
DR EnsemblProtists; EWC85304; EWC85304; PFNF54_05781.
DR VEuPathDB; PlasmoDB:PfNF54_140069900; -.
DR OMA; IMFGRQE; -.
DR Proteomes; UP000030673; Unassembled WGS sequence.
DR Proteomes; UP000232684; Unassembled WGS sequence.
DR Proteomes; UP000754359; Unassembled WGS sequence.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR016642; 26S_Psome_Rpn2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR004155; PBS_lyase_HEAT.
DR InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR InterPro; IPR048570; PSMD1_RPN2_N.
DR InterPro; IPR040623; RPN2_C.
DR PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF01851; PC_rep; 2.
DR Pfam; PF18004; RPN2_C; 1.
DR Pfam; PF21505; RPN2_N; 2.
DR PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR SMART; SM00567; EZ_HEAT; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW Reference proteome {ECO:0000313|Proteomes:UP000030673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 14..142
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 178..329
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 941..1148
FT /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18004"
FT REGION 364..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 999..1025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1041..1102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1172 AA; 132767 MW; 0764B9558DF9270C CRC64;
MRFENQFSKH DIVTSASGVI ALLNEEETSL KLFGLEKLNA IVDVYWPELA DSIFKIEELC
EDEDFVGREL ANLLASKIYF HLEKYSEALK YALCAGKLFN IKEKSQYVET MLAKCIEKYV
EIREMQYDID YNNQHNINDG ITNNNDIFNA YNNNDLVELN SHNELLNKET DIFRFDINNE
INQKMELLVD EMIDVCIKSN DIKEALGVAL DARRLDKVEY IIANAENKIE ILAHSINNEK
HINMNKSFRN EYFKLLVNLY LSLSEEELKT EYINLCECLY YIDDYKKVAE ILLKLLHNYH
LMAYQISFDL VDFENKIFLR NILGQIKENL IQNKAYYFGE EYFVTTPQEE NNDADNKENE
SNAITNEQQD ENNNEKEDKD NNDGKNPEHN DDNNKPNDNL TNDEPTYNNN DDKAINDGND
NDNNNNNNIN NNNNNIVEDV LKYISKKHIF YNKMKKLLYI LTGKVTGNLY IEFLHRNNHA
DLILLDTYKN IVDSRSSITH HGIVIAHALM QTGTTCDVFL RSNIEWLSKA INWEKFSATA
SLGVVYKGHV NESFMVLSTH LPYNDVSTEI ANNINVGLAP SGVYSEGGSL YALGLIHANY
NTNDKKVKNY LMSQLKSNMN DEVLQHGCCL GLGLVCLGDS NDENTYDELK AILYSDSAVA
GESAAYAIGL LKLGSGDDKC IDELLAYAHD TQHEKITRAC SISLGFVMFQ KEREADSLIE
ELVSDKDAII RYGGMFAIAM AYCGLSNCNK HIIKKLLHFS VSDVSDDVRR AAVIALGFVL
CNSPNQVPKF LNLLIESYNP HVRYGAALAL GIACSATANE EAINMLMPLL TDTTDFVRQS
AFISLGLIFQ QSNEHCNPNF KKYKEEIMKI LSDKHEDIIA KFGAIVSAGL LDICGRNAIS
TFFTRRGNII RPQAAAGFCL FSQLWYWFPL IHMISLTFMP TCLIGLTEDL KVPKNFSILS
TSNNQNFDYP SFLSKEKTQE KKETVTAVLS TTAKRKTLKL KKQKNDSKIT KERTAQDDNS
SVLSDGKSMK NLEILSTAAT IGQSSHVSHA ESVEGSANDE NSHDHAQDGS NISNVQKGKK
SEAKSKSGAN ENSNNNTVDM KNPCRVIKMQ EKYIEYIPNS RYIPVLPTRK SGFIMLNDIT
PLEPSECIEI NFEETSKKEA PPFEPFSWKE EN
//
