ID W7JY32_PLAFO Unreviewed; 594 AA.
AC W7JY32;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Holo-[acyl-carrier-protein] synthase {ECO:0000313|EMBL:EWC89918.1};
GN ORFNames=CK202_1343 {ECO:0000313|EMBL:PKC48695.1}, CYL21_1680
GN {ECO:0000313|EMBL:KAF4330044.1}, PFNF54_01044
GN {ECO:0000313|EMBL:EWC89918.1};
OS Plasmodium falciparum (isolate NF54).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC89918.1, ECO:0000313|Proteomes:UP000030673};
RN [1] {ECO:0000313|EMBL:EWC89918.1, ECO:0000313|Proteomes:UP000030673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:EWC89918.1,
RC ECO:0000313|Proteomes:UP000030673};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF54.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PKC48695.1, ECO:0000313|Proteomes:UP000232684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:PKC48695.1};
RA Bryant J.M., Baumgarten S., Scheidig-Benatar C., Scherf A.;
RT "Plasmodium falciparum NF54 genome assembly.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF4330044.1, ECO:0000313|Proteomes:UP000754359}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:KAF4330044.1};
RA Baumgarten S., Treeck M., Scherf A.;
RT "Genome assembly of Plasmodium falciparum NF54 DiCre.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE123757; EWC89918.1; -; Genomic_DNA.
DR EMBL; QFXU01000010; KAF4330044.1; -; Genomic_DNA.
DR EMBL; NYMT01000003; PKC48695.1; -; Genomic_DNA.
DR AlphaFoldDB; W7JY32; -.
DR SMR; W7JY32; -.
DR EnsemblProtists; EWC89918; EWC89918; PFNF54_01044.
DR VEuPathDB; PlasmoDB:PfNF54_040025900; -.
DR OMA; HADCQAD; -.
DR Proteomes; UP000030673; Unassembled WGS sequence.
DR Proteomes; UP000232684; Unassembled WGS sequence.
DR Proteomes; UP000754359; Unassembled WGS sequence.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008897; F:holo-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR Gene3D; 3.90.470.20; 4'-phosphopantetheinyl transferase domain; 1.
DR Gene3D; 3.40.390.30; Metalloproteases ('zincins'), catalytic domain; 1.
DR HAMAP; MF_00101; AcpS; 1.
DR HAMAP; MF_00009; Endoribonucl_YbeY; 1.
DR InterPro; IPR008278; 4-PPantetheinyl_Trfase_dom.
DR InterPro; IPR037143; 4-PPantetheinyl_Trfase_dom_sf.
DR InterPro; IPR002582; ACPS.
DR InterPro; IPR023091; MetalPrtase_cat_dom_sf_prd.
DR InterPro; IPR004568; Ppantetheine-prot_Trfase_dom.
DR InterPro; IPR002036; YbeY.
DR NCBIfam; TIGR00556; pantethn_trn; 1.
DR Pfam; PF01648; ACPS; 1.
DR Pfam; PF02130; YbeY; 1.
DR SUPFAM; SSF56214; 4'-phosphopantetheinyl transferase; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 2.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000030673};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 441..547
FT /note="4'-phosphopantetheinyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01648"
SQ SEQUENCE 594 AA; 70386 MW; A16B3AB22115DE5E CRC64;
MIFVLIFSKL KGAFYKILKL LCLYLFLYEE EYVLFYGKVK SLNTKTNAEC TYVGMRKGLR
VKPFKNIKDK NGLNILSSFC KRNDITCFNK INNFFCIGKN RFFRKRDILF YSYIIQNMFM
KRIYMNKGKR NTYYLINEHM KNDEYIDCNR RKYKKKLFNI YMEYNNMLYE EGDNFYDNYK
SNSFLEINNN QVNIPIDLSR FEKEVRKLIE ILNYKNFHLN ITFVSLEEMK RINKKHRNKD
MATDVISILH YLDDPNYDYN YDFLKNAIGG KKGFKSGDIY LCPEYINREC FLSRMNYEKS
LLDKKGDSLE YVSEMKKNVT DETFEDITEG SINRTSCNVY DISVDDNDVG ITSFDKVSKN
VDTNKILNPR GVNKLFSNIF SVNERLPFYV LHGFVHLMHK DHENNVEEYN EFMDIEENII
KKYMTFNKYT PTFYAHYIIG LGTDILCVYR IYKILLLKNK NKFLQKVLNS LEYKELIQQD
DTIKYNIEKL AIYISKKFAA KEAIVKSIGR GLSSISKYGI SMNDIEIRND KYGKPHVYLY
NKAKKIARQL GIVKIFLSIS DEKIFNNNIK INNVNKKNFT CLIHAQALAV GSNI
//
