ID   W7K0K9_PLAFO            Unreviewed;       795 AA.
AC   W7K0K9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=PI3K/PI4K catalytic domain-containing protein {ECO:0000259|Pfam:PF00454};
GN   ORFNames=PFNF54_00458 {ECO:0000313|EMBL:EWC90813.1};
OS   Plasmodium falciparum (isolate NF54).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC90813.1, ECO:0000313|Proteomes:UP000030673};
RN   [1] {ECO:0000313|EMBL:EWC90813.1, ECO:0000313|Proteomes:UP000030673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF54 {ECO:0000313|EMBL:EWC90813.1,
RC   ECO:0000313|Proteomes:UP000030673};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum NF54.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type II PI4K
CC       subfamily. {ECO:0000256|ARBA:ARBA00008941}.
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DR   EMBL; KE123732; EWC90813.1; -; Genomic_DNA.
DR   AlphaFoldDB; W7K0K9; -.
DR   EnsemblProtists; EWC90813; EWC90813; PFNF54_00458.
DR   OMA; IMPHIMD; -.
DR   Proteomes; UP000030673; Unassembled WGS sequence.
DR   InterPro; IPR044571; P4KG1-8.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   PANTHER; PTHR45800; PHOSPHATIDYLINOSITOL 4-KINASE GAMMA; 1.
DR   PANTHER; PTHR45800:SF11; PI3K_PI4K CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030673}.
FT   DOMAIN          4..285
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00454"
FT   REGION          614..702
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        614..661
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        677..696
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   795 AA;  92073 MW;  DE1C36FCBF81B064 CRC64;
     MDGTGGTYLL YNAKKKICSV FKPLDEEAFA PFNPRGYEGK MYQEGFRAGV LSGEGASREI
     AAYLLDNCYN NFSNVPCTIM VEACNPHFNN KSKLKYVDKE TNLKWKCGSL QEFIDSRESV
     GNYDYKQFSI RDIHKIAILD IRVMNLDRND GNILVSPLKT LKDSCNQFVY RNNKFTSSNN
     EDMLKRIITI DKKPSRYTLI PIDHGLILPH IMDVAEIDLV WFEWPQIKIP LDDEELEVVF
     SFDPDKDAEK VRNKLLIRED CIRTMRVCTR LLQIGAKMHL TLYEIAKIST RKNIDEESIL
     EHLVKDSITQ AYQMMDYTSL MSTNRLGYIL DLAEIKMNKK KKNSKIKTVE INDDKIINQL
     YEKNQGNLFF NEKGETTGGE GSLKSPPSIK KDNDIIKSNI YNKNVSNNNL IKDVDDMISI
     NSSSNTTNSI KNVSLINESY KNIYSNNVIK NNNSDFFNKN IENNIDLMNI TNQVNNINLC
     LNIKKEDNET NGEENDMSLK QNNLKHTHLN SRSDFSKECE NTTESKNITM KLKKENFSNN
     SPDNLLDKPL DTLLNEPLDH FLGKPLNKFV DKPLDNMLEN ISGEVSDMSN ISNNLSNVSD
     KIKVDTSEYK DEALFCNSPN DDTKVKKKKK KKDSDLDGYP KDQKNYTNCD DGDKINSDDN
     GINKENEMIN QVKNNLNDDE EEEEEEEEEE EEENDDYDVT FKKPSGTIKR ISENTGTAYR
     SMEMNKINSI WMIRDKNNKI INVKWENKIF EKLFFETFEN YIKKYINDYH RDWRNYPYNG
     SKITTTKHAY LNNIK
//