ID   W7KKN9_PLAFO            Unreviewed;       719 AA.
AC   W7KKN9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   13-SEP-2023, entry version 36.
DE   RecName: Full=T-cell immunomodulatory protein homolog {ECO:0008006|Google:ProtNLM};
GN   ORFNames=CK202_3565 {ECO:0000313|EMBL:PKC45880.1}, CYL21_3237
GN   {ECO:0000313|EMBL:KAF4328488.1}, PFNF54_01253
GN   {ECO:0000313|EMBL:EWC90127.1};
OS   Plasmodium falciparum (isolate NF54).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC90127.1, ECO:0000313|Proteomes:UP000030673};
RN   [1] {ECO:0000313|EMBL:EWC90127.1, ECO:0000313|Proteomes:UP000030673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF54 {ECO:0000313|EMBL:EWC90127.1,
RC   ECO:0000313|Proteomes:UP000030673};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum NF54.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:PKC45880.1, ECO:0000313|Proteomes:UP000232684}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF54 {ECO:0000313|EMBL:PKC45880.1};
RA   Bryant J.M., Baumgarten S., Scheidig-Benatar C., Scherf A.;
RT   "Plasmodium falciparum NF54 genome assembly.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KAF4328488.1, ECO:0000313|Proteomes:UP000754359}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF54 {ECO:0000313|EMBL:KAF4328488.1};
RA   Baumgarten S., Treeck M., Scherf A.;
RT   "Genome assembly of Plasmodium falciparum NF54 DiCre.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TIP family. {ECO:0000256|ARBA:ARBA00006496}.
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DR   EMBL; KE123757; EWC90127.1; -; Genomic_DNA.
DR   EMBL; QFXU01000015; KAF4328488.1; -; Genomic_DNA.
DR   EMBL; NYMT01000012; PKC45880.1; -; Genomic_DNA.
DR   AlphaFoldDB; W7KKN9; -.
DR   EnsemblProtists; EWC90127; EWC90127; PFNF54_01253.
DR   VEuPathDB; PlasmoDB:PfNF54_050033100; -.
DR   OMA; PGDWIPW; -.
DR   Proteomes; UP000030673; Unassembled WGS sequence.
DR   Proteomes; UP000232684; Unassembled WGS sequence.
DR   Proteomes; UP000754359; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR024881; Tip.
DR   PANTHER; PTHR13412:SF0; T-CELL IMMUNOMODULATORY PROTEIN; 1.
DR   PANTHER; PTHR13412; T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG; 1.
DR   Pfam; PF13517; FG-GAP_3; 1.
DR   SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030673};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        676..697
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   719 AA;  82905 MW;  B4DE47410A8D81C1 CRC64;
     MYNFLSCKKK SIILQVLLII CTYNILLNFV NIFVNNNEKN HKNKYENRIK SFYVEAYNWN
     FLEKWKSINT NEKLEYKINY NIGLNIDAEI GDFGDYNSDV KTDLILFKYD KDKLLSTIFI
     YVFSVKENKF IYHTEVSFEG KIMNVTAIDL NFDGALDVLV LFKDNKDSSK SNKYYVAAFL
     QNDNDQLEEI WNSKKKEQND ESITDNEEDN IYYTNIHPLI CDINNDGLPD IIGQQSGGPD
     GFFRFIWINT RNGFKSFLWK NINIFKYSEL DEITNPNSSA IVDINGDCKS DLVFTVYNSY
     EKRIGLEIWL NKIIDGKSFY VKYSQDYLLP PNSLQVLFGD FNGDGSIDLV VPTCVKSSFC
     NYCCVSDDKI YFIPNIQKKI CDSSWKKPDE TKCRPASNLC SESDFEFQQN LTDDFISVVD
     TSGLHLSGNA DYPYYLSVGD IDDDGYLDLL ITLKNDKGQK YVRIYKNELK IHYEENSLEV
     RGFYNFYQFV TSPEESVTDV YNAAFFDIFE NGVLDILIFG KYITSNKKTK YAAVGFIRNN
     ETDSLFLKST ALNGICVNDC YKEKDKITTK TLGGNAHGPT FKITVIDVNG VKSSRIGVQK
     SQSAHFPLQL PYVLFGLGRT SNYVEEFYVG MPTHEQKYYN MWVSIIPNSH IIVIPYPLNN
     SNKWQIQLSV NPSKKFYSIL YITLICLSVI GVLIFILDRK EKVEDSKEEL GFKSHFVIG
//