ID W7M735_GIBM7 Unreviewed; 1125 AA.
AC W7M735;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Cell division control protein 25 {ECO:0008006|Google:ProtNLM};
GN ORFNames=FVEG_16025 {ECO:0000313|EMBL:EWG46816.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG46816.1, ECO:0000313|Proteomes:UP000009096};
RN [1] {ECO:0000313|EMBL:EWG46816.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600 {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
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DR EMBL; DS022249; EWG46816.1; -; Genomic_DNA.
DR RefSeq; XP_018753007.1; XM_018905261.1.
DR AlphaFoldDB; W7M735; -.
DR GeneID; 30072901; -.
DR VEuPathDB; FungiDB:FVEG_16025; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000009096; Chromosome 7.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000009096};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 67..126
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 786..919
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 955..1125
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..166
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1125 AA; 125831 MW; D7895C1D90C1D55B CRC64;
MLKIQNRRRA ASIHSSRTIH DPSGDSPSAS VRITSAASVQ ASDQQSSTTR ADRAWGLMNG
IVGTAPMGAM YVRALYDYEA DDRTSLSFHE GDVIQVITQL ESGWWDGVIN GVRGWFPSNY
CQLITSPDDI PDSAHNGTFD AVEDDAEDPE MYDDQYDQDD DSEQDGPIAL PLEGTDGGDS
SRADFWIPQA TPDGRLFYYN MMTGDRSMEL PLESPVSSNE TGPRDRMNVN IPDKTRPPPE
MMARGLTQDE DDEYLTSASE AEGDSSRLAS RRSKHTKRAS FGALSPSTSM DSINGASPVG
RLRNGASSNG HLTAGQVPNI ASATSFTSTT YNLPTTATVP RSFFDDGSTP SLSWTLLVSN
MRRAIDRYRE AIMNNNRSEY VAKAEDISDH LRLLLAAGSG TTDNHSGQPS IISTNKALYP
HFRDMMSKFS KLVISSHIAA ADWPNAESIQ KCLQEADGVL MGVYSYVEVA RQQRGEEIPR
LFPGFVIGSN TGGSWQNNGL GPRDEITANF LEDEEGVVEP TAILDNKMLE RLDEQKRILV
SSIRELDKSL VVLEKIVTPY RHEVIGNNVC FAGGRVLDTF RQWIAMIESI DLSSLGNSFQ
TPQLADLGTH KQSLYDNISD LILGCQAVAG PLADEWSEVR GEALENRLEY VRQCARALET
NSSHIGFSLQ LLSEQVQINM QQHQAEVRPR ENSFVRSTLQ RGETMPYDRP HQRTESRTAP
VRPPLITSQS FTEGEPAPGN MRRGDYSKVK KIFGEDPSPQ VPVTEDTPEF LLLDYEHEVS
WDSKTSPPTV KGGSLLALVE QLTRHDKLDS NFNNTFLLTY RSFTTARELF EMLIKRFNIQ
PPEGLSQADF EIWRDRKQKL IRFRVVNILK NWFDNFWMED YNDESKQLVR DVYSFAKDTV
KSTETPGSAP LMAVLDQRLS GKEAGARRMI QTVNQNTPTP IMPKNMKKLK FLDIDVVEFA
RQLTIVESRL YGKVKATECL NKTWQKKVPE GEPDLAPNVK ALILHSNQMT NWVAEMILAQ
MEVKKRVVVI KHFVSVADRC RSLNNFSTLT SIISALGTAP IARLKRTWDQ VPQRTHATLE
SMRRVMASTK NFGEYREALH AANPPCIPFF GTDPFPRKAG DKSHY
//
