ID W7MH84_GIBM7 Unreviewed; 4924 AA.
AC W7MH84;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=FVEG_05323 {ECO:0000313|EMBL:EWG44162.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG44162.1, ECO:0000313|Proteomes:UP000009096};
RN [1] {ECO:0000313|EMBL:EWG44162.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600 {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR EMBL; DS022247; EWG44162.1; -; Genomic_DNA.
DR RefSeq; XP_018750353.1; XM_018893499.1.
DR STRING; 334819.W7MH84; -.
DR EnsemblFungi; FVEG_05323T0; FVEG_05323T0; FVEG_05323.
DR GeneID; 30063330; -.
DR KEGG; fvr:FVEG_05323; -.
DR VEuPathDB; FungiDB:FVEG_05323; -.
DR eggNOG; KOG1808; Eukaryota.
DR HOGENOM; CLU_000050_0_2_1; -.
DR OMA; ILEQWHR; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000009096; Chromosome 3.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 8.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000009096}.
FT DOMAIN 4714..4915
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 752..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4056..4092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4104..4632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4114..4166
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4167..4217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4218..4239
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4261..4310
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4365..4411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4436..4480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4529..4546
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4557..4601
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4924 AA; 551815 MW; F314EF66C20231AE CRC64;
MAMIDVSRQR RSLLADATVL EHLPAEILAI IQDQSSTKLL DAVAEAALCP PLTERIFAHF
EHLFPDVCAR WILNPGNEQQ RIRIYSALAR ILPFAPYLST FIEYASSTPE QTTNSPSLRL
PPLRLDQNAM EQDGEILLQS LLVVWRLISF DSRNFGPLTS AALMQTLFKH ESRAVRYLAT
RIFIQLLHGS DWKLESLIQE HIGKSEAILA DFDGRSIDYG FLSLYEQSRV KSFLALREEV
QAAHEAATDD SPLTQTLTPY VVCYGNVILP RPLGPTGEPS SLVLTPTTVS NLERLATMLR
ESDPVMLYGL PGVGKTALVH EVAKQLGMYS NMVTLHLNEQ TDAKMLIGLY STDSKPGSFQ
WRPGVLTTAV KEGRWVLVED LDRAPTEVLS TLLPLIERKE LLIPSRGERI RAASTFRLFA
TVRTSRGMNG RENLPSLVGI RFWQSLSTQA LAASELEDVV GQTYPILRKF IPSILAVYAR
LCRLGSTPGA LARGRNIMDR QVTLRDLLKW CRRLHECLVA AGSKTGEEPI TKTTSDQMFL
EAVDCFVGSC PDPEIGRQLI VAIAEEMQLP KELAEHYFTT HIPNLNESDN QFSIGRAVLR
KKKQSNRIQK SKRPFASTAH AKKLLEQIAV AVKLNEPVLL VGETGIGKTT VVQQLAESLG
HKLIAVNLSQ QSEVGDLLGG FKPVNTRTLA MPLKEEFEDL FSATGISASK NQKYLEQVGK
CFAKGQWSRV SKLWKEAPKM FNKIVKELER VHTEQAETRN GDEQPTKRRK TQSKLQTLLD
LRPRWDMFAR NLEQFDVQIS GGSGSFAFSF MEGNLVKAVR NGDWVLLDEI NLASPDTLES
IADLLTGPAE RPSILLSETG EIEKIEAHPN FRIFGAMNPA TDIGKRDLPV GIRSRFTEVY
VSSPDKDLKD LLTIIKTYLG SSNSKNDQAA DDIARLYINT KRLAEEKRLV DGANEVPHFS
LRTLTRVLSY VNTIAPYYGV RRALYEGFSM GFLTLLDRES EKMLVPLISH HLFEKHGNPQ
SLLSQAPKHP NDGKQYVRFK NKNRDRQYWL FQGSETPIER EDYIITPYVE RNLLNLVRAT
STRRFPILIQ GPTSAGKTSM IEYLANFTGN KFVRINNHEH TDLQEYLGTY ISGSDGKLSF
QEGILVQAMR QGHWIVLDEL NLAPTDVLEA LNRLLDDNRE LLIPETQEIV KPHENFILFA
TQNPPGLYGG RKVLSRAFRN RFLELHFDDI PEDELEFILQ QRSRNTSPPD CRRIVNVYKE
LSRLRQTSRL FEKKDSFATL RDLFRWALRE ADTREEIAAH GFMLLAERVR NEEERIAVKE
VIEKVFKVKI NPQDLYSATV APELKHFTSE PNSQGVIWTH AMRRLYVLVS RALRNNEPVL
LVGETGCGKT TVVQLLAEAL KKQLHIVNAH QNTETGDLIG SQRPVRNRGA IVDALDADLK
WVLQSLCLDV SGSVEDRLDR YKALDPSVTS EISQEVKERI TANETRSKAL FEWTDGSLVE
AMREGHFFLL DEISLADDSV LERLNSVLEP SRTLLLAEKG IDNSFVVGAD GFQFFATMNP
GGDFGKKELS PALRNRFTEI WVPALSQTED IYEIVKTKLH GDSKQLVEIV VKFAAWFGDT
FRSMASAPFS VREILVWVQF INTFQSDEPV VSLVHGASTI FIDSIGANPS ALLATDPKSL
GQQRQKCLDK LSELIGKDVS GVYETHPELS MDGISLTIGH FSIPRASAGV ADHGFAFHAP
TTRLNAMRVL RALQMQKPIL LEGSPGVGKT TLVAALSQAC GQPLTRINLS DQTDLMDLFG
TDVPVEGAEA GNFAWRDAPF LQAMQKGEWV LLDEMNLASQ SVLEGLNACL DHRGEVYISE
LDQVFKRHPD FRLFAAQNPH HQGGGRKGLP ASFVNRFIVV YADVFSDDDL NLIAAHNHPK
ISPSVISQLI QFVSQLDHKL AVEKSFGTQG SPWEFNLRDV LRWLRLLDSS DPLLQNAYAD
DFLDIIVRQR FRTERDRKEV NDLFTLISGS VPRQHSLHHD ISPLFGQVGL ALLDRHPHSQ
PERLPNIDIV PRLSELESIM ICVKQNIPCI LSSPSGYGKT VLLEHVAALA GKSLVVFPMN
ADIDTMDLVG GFEQADPIRE VNAALRALRR DLQNIIMSAV PDDIPIEALH LLHLLDGFTG
DVDSLPPIAT SVKHLLGSVP ADSEVAIVLS KALNPLQHSL VLENPRFEWL DGVIVKALQL
GQWLVLDNAN MCNASVLDRL NSLLEPNGFL SINEHCGPGG EPRVVRPHPD FRIFLTMDPR
YGELSRAMRN RAVEIHIHTP PPSLDRSYHR VVSVESSLQR YNTSHQISHT VLNTGGSVEV
IERALETLSI ADLPLLPQFT GTLSNHDTHS RALSFAVTEL LGFLNSSNGA DGVNGISHLY
SSLPIPEGLK PAQPLHPLNN FPISQLLSAP DQARWLGACL GFYHELNRLQ NSIEDQRCQA
QVNKLTALNR LQRSLISDRV AAVSKDATVK LASFSLFVIN TVKEWLGIKF ESLEKWTERV
RVLRGIVCYL KRTIRLGIES DFDEAKFQAH LAQGANFLQK HLDTSTGSQE KEFISLLIER
LGKDFTAGFK LSTGLSMELL WHIFRPTPLP TKMILDRTIE LEKLGSRFDS LRWKAGASIS
DLTKAMATLE KASGILREDA PNVDSLLQDL ATEIQSLESR IGVDEVERKP FMMDEFEALR
QVSMLKSLPS GDTELQVLSD IPTQAGMMLA SSNLQAALLQ SVENLVYQNK FSWDGKFVSC
FWKKLQNLGS VNLGSLALLE AELPIAGRQI MKLSADVVAN PLTRLNNVLS QLVLEVFSAH
NQSLKDAVIE AAQLASQDLA RSSRAFDDLA PRIETEHFRE IVVEHLIPAL KALTTLQCDI
QREAQLSAFA WIHFSIGAVK LYVPDRVFDP QSRPKMEREF LQEMHTALNV EADSLRTFEK
HFTGQDTNER IRLLEAESAV LGPLPEEVRA IYRPDQSELN RIHAEFSNVL KAVTGPTLSA
ALQILDIDPA RATEELQLVK ENVLRLLDRL SSRFEAYQDM TRPTSNLLRC LMIGLSLCDA
ASAHNLAPAS YQLLEVTPFL GGSMWNQLDG QFSSRTFEFL NYMSVVASIE GIDNIQQQAR
EMVFRSFHNL FDEWTKRLEA DRKEQTAKGS LYRFRGSLED EEQVDAEEFN ELFPTFDEDE
DADVPTNKKP DEVRDQSLRV AEIHKSLFLN PPQFTTALKD ACKSVGDRIT SETIDHKNID
RSLTSKMLAG TMFFLNDKLD SLVSSTVDKS YNFYTDANVP EARQLVVLMH KIKSRFRELQ
MVDEIGHMQP LADVIHACEQ VLELVHTEPL AKILPKVEHL HSHVYEWQFG GWASKIYGVL
TLHNLLTDTV IRWRRLELST WANLFDMEQK KCQDDAYSWW FVAYQVVIAV PLSLVEVTDE
LKEYASSLIS SLEMYFSTAI IGQYGARLAL LRQLQNHLKL LTEDYPVLQL ILHALSNFIQ
YYSRYEKIMD ETICKGRLPI EKKMKDVLLM ASWKDTNINA LRESARKSHQ KLFRIIRKFR
GVLGQEAKQI IEQGLPDQNV HHANYVGDKS PIMDVPADVF SKLNNALPGW TDGHKRLANV
SKTVSVMRKI SDNPEMTSQV PQIVDDYLSS LSDSMAELRK ETPPFLTDEN KDQVKHLKTR
KRKLFADTLR DLRQMGFKHN LGQDKLAEQA SLSVVLSSIQ PVQLPSDNST EAMDYHLHKI
LDLIPKVRAA SRDHSEDLTS AEVARSAGFV EGMLNLLLTQ RYSITSGASS LSLLEQSIKQ
FSRLGLSHEH GLLIRKTAVS DWKRLLPWLV QILQHAIRLI EIHGKLGEMK HTTAIEQLKS
WHGRFESLHA LNAGFGQLPD GVSSEAAAHA EANLSSELAS FRADLEELNS EQPELSFILL
QIVGWTKITR EAAPSLTSDD MEITTFANSI STLCDKILVA IESVKKATKG ADYREDEPAW
LIGHANSFVN LFTKLRTAEI ERSVASCIKM LKHIHLEEPN LSQAAMSLMT IAYPVLNEYI
HFAQQTLMQV VDIHSAIAHM SYNMTKTFTQ ISSQGFCTPQ EKSDETSGES GKVESGTGLG
DGEGAEDISK DIQPDEDLSE LAQEANKEEN GEMEDEKDAV DMADEELEGD MGSVDGADDD
DTGSKNGDEE EEENDMDEEA GEVDDLDPTA VDEKMWDGED EEKADKDQQG EKAKGQKKDD
EQMAADEDAK KQESEEQPDV DDSGEQDAEE EEAGAEEEEV KAQEEMNKQD QTAQENDTLA
LPEDMELDLD DDHESASDSD DLDGLSDIEE ENREGEDQEM NNEEEDGSDD AAAQAQLQEE
AGEETEIQED EEMPEEKAGG KDEVDEEAKP EEDEKDKDQE DATDQNQSPQ DNATADTDNA
APSDVKSSGQ DQNADSMDVD DNFQSNAAQQ EDGEMGEGAA DQDTSAGNKG SASQSKEIMD
RAEQEQEKAD SARSDPFKKL GDALERWHRQ QEDIKDAESS DTNEQNAPQD PSADQGRKEF
QHLQDDETAT DTQAMGTADD EQVQPIDESM AIDEERQDPT SRLVDDDTEE AEQDPDKMDT
ADPGEAPDAS KQDANNDQDE TRSGVKTRQG NYDREFSPSD QEAQLDEQED EVEIQETSTQ
LSSTHISDEE RPLRDFGESM QQWTEFQTKT HSLSLALTSQ LRLILTPSQS TKLSGAFRTG
KRLNIKRIIP YIASSYKRDK IWMRRSIPTK RTYQILLCVD DSKSMGETSS GTLAMESLVM
VSRSLTMLEA GQVGVMGFGS DVFTAHGLTE PFAADAGAKV LQKFNFSQDR TDIALLIQRT
IETFRLARQQ GSSNSDLWQL ALILSDGLTP SSAHEGIRRM LREAMEERIM IVFIIMDDTG
KKKGDSVLEL KEAKFVRDGG ESKVVIERYL DTFPFQYYLI VHHLEELPSA LAGLLRTWFA
EVNA
//
