ID W7N4P2_GIBM7 Unreviewed; 604 AA.
AC W7N4P2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=FVEG_10517 {ECO:0000313|EMBL:EWG51592.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG51592.1, ECO:0000313|Proteomes:UP000009096};
RN [1] {ECO:0000313|EMBL:EWG51592.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600 {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
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DR EMBL; DS022256; EWG51592.1; -; Genomic_DNA.
DR RefSeq; XP_018757783.1; XM_018899677.1.
DR AlphaFoldDB; W7N4P2; -.
DR STRING; 334819.W7N4P2; -.
DR EnsemblFungi; FVEG_10517T0; FVEG_10517T0; FVEG_10517.
DR GeneID; 30068101; -.
DR KEGG; fvr:FVEG_10517; -.
DR VEuPathDB; FungiDB:FVEG_10517; -.
DR eggNOG; KOG2304; Eukaryota.
DR HOGENOM; CLU_031652_0_0_1; -.
DR OMA; KGWQGRI; -.
DR OrthoDB; 4517707at2759; -.
DR Proteomes; UP000009096; Chromosome 11.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075:SF3; 3-HYDROXYACYL-COA DEHYDROGENASE; 1.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SMART; SM00135; LY; 3.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009096}.
FT DOMAIN 14..185
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 190..282
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 604 AA; 66673 MW; 31B0522BF54F1E4A CRC64;
MTWLPPKDYT SRPIVILGGG VLGRRIAACF ASVGWHVIIR DPSERSRADA VAYIDASITD
YLTISHGEKG SWEATEDFDA AVRDAWLVFE AVPEILSIKE DTFLALEKQA PADCILASNS
SSFMSRELLG KVKESTKARV LNTHFMMPPQ ALIVELMTSG STASNLFPFL SQEMTKCGLK
PVTAKKESPG FIFNRIWASI KREVLMVIAE GVADPQTIDR VWMDMYQSPT GPCTMMGVGL
DTVEHIEENY VEKRGLPKTT LKWLHENYVA KGKLGNKSDQ GGLYPVPPSG EKTKLLVLNF
YQGASPGELT PETYLSSGQI LEFSVENKNA RPNALVSGQA VPDGIDVCDD RMYWTCMGYP
PTNDGAVYSA KLDGSDIRTV IPRGHVHTPK QLHISQKSKK IYFCDREGLR IHRCNLDGSK
HEILFQTGNF TKEPEKVADQ TNWPVGITVS DKLGKIFWTQ KGPSKSNGGR IFSAGIDIPE
GSDASSRKDI DLIAKDLPEP IDLEFDEDNG VLYWTDRGEM PLGNTLNKKT IVGQPPATEN
KLGRQIIAQG FAEAIGLRLD KKRDCIYVAD LAGRLWQCET VPGPKKKIFE SAGHAYTGLA
IVRD
//
