ID W7RPW5_LYSSH Unreviewed; 365 AA.
AC W7RPW5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Prephenate dehydrogenase {ECO:0000256|ARBA:ARBA00016891};
DE EC=1.3.1.12 {ECO:0000256|ARBA:ARBA00012068};
GN ORFNames=P799_05420 {ECO:0000313|EMBL:EWH33642.1};
OS Lysinibacillus sphaericus CBAM5.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX NCBI_TaxID=1400869 {ECO:0000313|EMBL:EWH33642.1, ECO:0000313|Proteomes:UP000023555};
RN [1] {ECO:0000313|EMBL:EWH33642.1, ECO:0000313|Proteomes:UP000023555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBAM5 {ECO:0000313|EMBL:EWH33642.1};
RX PubMed=25685257; DOI=10.1186/1944-3277-10-2;
RA Pena-Montenegro T.D., Lozano L., Dussan J.;
RT "Genome sequence and description of the mosquitocidal and heavy metal
RT tolerant strain Lysinibacillus sphaericus CBAM5.";
RL Stand. Genomic Sci. 10:2-2(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC NADH; Xref=Rhea:RHEA:13869, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC ChEBI:CHEBI:36242, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001162};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00005067}.
CC -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007964}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWH33642.1}.
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DR EMBL; AYKQ01000008; EWH33642.1; -; Genomic_DNA.
DR RefSeq; WP_012293647.1; NZ_KK037167.1.
DR AlphaFoldDB; W7RPW5; -.
DR HOGENOM; CLU_055968_2_1_9; -.
DR OrthoDB; 9802008at2; -.
DR UniPathway; UPA00122; UER00961.
DR Proteomes; UP000023555; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04909; ACT_PDH-BS; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR046826; PDH_N.
DR InterPro; IPR003099; Prephen_DH.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF01842; ACT; 1.
DR Pfam; PF20463; PDH_C; 1.
DR Pfam; PF02153; PDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Tyrosine biosynthesis {ECO:0000256|ARBA:ARBA00022498}.
FT DOMAIN 3..291
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
FT DOMAIN 295..365
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 365 AA; 40085 MW; ABE1BB9D8C7CE508 CRC64;
MTRNVLVIGL GLIGGSIALA LQKAPDTKII GYDMDAQTRE HAQALNIVHD TVTDPQAIAA
DVDIIIFGTP VNATLEWMEQ LKSWPLKNKV IVTDTGSTKK LIMQKAGELR ELGITFIGGH
PMAGSHKSGV LAAKAHLFEN AYYMLTPLAG EEIVHMAQLE SLLKFTHAKV VSVSASEHDH
MTAVVSHFPH VIAASLVHQL GGENGEYPMT RSLAAGGFRD VTRIASSNPV LWRDITLQNR
DELLTQLEGW EKEMGRIKDL LTNGTSRDIE DYFSIAKELR DELPISAGAM YTAFDLYVDV
PDYPGVISEV TGLLADEAIS ITNLRIVESR EDVFGILVIS FQSENDRERA AACIQKRAKF
ETYIS
//
