ID W7TPH5_9STRA Unreviewed; 718 AA.
AC W7TPH5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Polycystin cation channel, PKD1/PKD2 {ECO:0000313|EMBL:EWM27927.1};
GN ORFNames=Naga_100008g84 {ECO:0000313|EMBL:EWM27927.1};
OS Nannochloropsis gaditana.
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Eustigmatophyceae;
OC Eustigmatales; Monodopsidaceae; Nannochloropsis.
OX NCBI_TaxID=72520 {ECO:0000313|EMBL:EWM27927.1, ECO:0000313|Proteomes:UP000019335};
RN [1] {ECO:0000313|EMBL:EWM27927.1, ECO:0000313|Proteomes:UP000019335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-31 {ECO:0000313|EMBL:EWM27927.1,
RC ECO:0000313|Proteomes:UP000019335};
RX PubMed=23966634; DOI=10.1093/mp/sst120;
RA Corteggiani Carpinelli E., Telatin A., Vitulo N., Forcato C., D'Angelo M.,
RA Schiavon R., Vezzi A., Giacometti G.M., Morosinotto T., Valle G.;
RT "Chromosome Scale Genome Assembly and Transcriptome Profiling of
RT Nannochloropsis gaditana in Nitrogen Depletion.";
RL Mol. Plant 7:323-335(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWM27927.1}.
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DR EMBL; AZIL01000356; EWM27927.1; -; Genomic_DNA.
DR AlphaFoldDB; W7TPH5; -.
DR EnsemblProtists; EWM27927; EWM27927; Naga_100008g84.
DR OrthoDB; 276868at2759; -.
DR Proteomes; UP000019335; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF7; SD02261P; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019335};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 90..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 526..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 429..552
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 38..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..614
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 718 AA; 81461 MW; 3FD1E85370173283 CRC64;
MDNQTAEVQA PEEESCREPH PPLFWPQSSA FSMMRTIAQG GKQRQQSAAP KPPLLTPASR
QHSLRMSAED HHGLSAWEKW TRFRRFPFKL ILHALLLIAV TSQLLLLNRN DASYQRAMQR
TFACFFMPKG VKDGMGRRLL FTNQGFLMSL AEASQNYFRL NELSAVSFFY RNEPHGPRAV
GTAIGGRPSN LNLTPTPFKM RLEVAGNYDP PAPFPLDHWV RDPVDLGPFA AAIAEDRDNV
TAGGQKTVPP ELARLLDSLM SVTLDMVLCN SLEGRQHGAW EERCFCWHVS TLYNFRQGGN
AHLTLSQHII SPCSYQTSIV RYLSSRVGIL NFITALLAST YLVLIFKSLH ASIAVYRRVR
LAYPLSHHPL RRRYPTWAHV PWRLKRKFFS FYLLLIGLGT LLSLVSVLLS SYYTRTYSPA
LWSHKLCAGI GALCLWIGVL RFFQPYPHLY SLIPTLDAAA PRLIPFLAGV FPIFFAFALL
GVSLFGRDVL LFASLSHTLS SLWSLMNGDS LYNIINASRA THPVLANLYM YTYITLAIYV
VINIIIATTE EAFFHSRHVQ RLAHRFLKRS LRQLDEMREC EEEERGVCSK GASMDAQSEE
EEAEEWEEEE DGDKEGGVNT VGGGEVVSSG VSTAGSSTFP EIQRGRQRWT ETEREWGIEE
EDHECGSERR SEKPRRGRSD TLFLVYALER QQEEVFEAIL RLLVKDYKIE GRDEGREG
//
