ID W7WIN7_9BURK Unreviewed; 458 AA.
AC W7WIN7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00020675, ECO:0000256|RuleBase:RU000644};
GN Name=infB_2 {ECO:0000313|EMBL:EWS59744.1};
GN ORFNames=Y694_02452 {ECO:0000313|EMBL:EWS59744.1};
OS Methylibium sp. T29-B.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Methylibium.
OX NCBI_TaxID=1437443 {ECO:0000313|EMBL:EWS59744.1, ECO:0000313|Proteomes:UP000019360};
RN [1] {ECO:0000313|EMBL:EWS59744.1, ECO:0000313|Proteomes:UP000019360}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T29-B {ECO:0000313|EMBL:EWS59744.1,
RC ECO:0000313|Proteomes:UP000019360};
RA Gyula P., Szabo Z., Robotka H., Bihari Z.;
RT "Genome sequencing of the loss-of-function mutant Methylibium sp. T29-B.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: One of the essential components for the initiation of protein
CC synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC and promotes its binding to the 30S ribosomal subunits. Also involved
CC in the hydrolysis of GTP during the formation of the 70S ribosomal
CC complex. {ECO:0000256|RuleBase:RU000644}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733, ECO:0000256|RuleBase:RU000644}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWS59744.1}.
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DR EMBL; AZSN01000059; EWS59744.1; -; Genomic_DNA.
DR AlphaFoldDB; W7WIN7; -.
DR PATRIC; fig|1437443.4.peg.2484; -.
DR Proteomes; UP000019360; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01887; IF2_eIF5B; 1.
DR CDD; cd03702; IF2_mtIF2_II; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR044145; IF2_II.
DR InterPro; IPR006847; IF2_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR000178; TF_IF2_bacterial-like.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00487; IF-2; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF5; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF04760; IF2_N; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|RuleBase:RU000644};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU000644}.
FT DOMAIN 66..233
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 385..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 458 AA; 49742 MW; D26485C706F72866 CRC64;
MSVKASEVIK QLMKLGQMVT INQQLDQETA MILVEEMGHK AFTAKLDDPD AFLEDDVEVT
DVPLEPRAPV VTVMGHVDHG KTSLLDYIRT TRVAAGEAGG ITQHIGAYHV ETPRGMITFL
DTPGHEAFTA MRARGAKATD LVILVVAADD GVMPQTKEAI HHAKAAEVPL IVAINKIDKP
GTNLERVRSE LIAEQVVPED FGGDSPFVQV SAKTGQGIDE LLEQVLLQAE VLELQAQVAA
PAKGLVIEAQ LDKGRGPVAT VLVQSGTLKR GDVVLAGSTY GRVRAMLDEN GKPATEAGPS
IPVEIQGLTE VPQAGDEFMV LSDERRAREI ATFRSGKYRD VKLSKQQAAK LENMFETMGQ
GEVQTLPLII KPTCRARRRR WAPRCSSSAR PRSRCRSSTQ RWAASARATS TWPSRRRPSS
SASMCGPMPV RASWPRATTS TCATTTSFTT RSTRSSRR
//
