ID W7WWB4_TETTS Unreviewed; 996 AA.
AC W7WWB4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Cyclic nucleotide-binding domain protein {ECO:0000313|EMBL:EWS71125.1};
GN ORFNames=TTHERM_000841359 {ECO:0000313|EMBL:EWS71125.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EWS71125.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG662249; EWS71125.1; -; Genomic_DNA.
DR RefSeq; XP_012656333.1; XM_012800879.1.
DR AlphaFoldDB; W7WWB4; -.
DR GeneID; 24440885; -.
DR KEGG; tet:TTHERM_000841359; -.
DR InParanoid; W7WWB4; -.
DR OrthoDB; 238326at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016409; F:palmitoyltransferase activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR24178:SF9; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF01529; DHHC; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 660..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 857..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 910..934
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 374..406
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 811..943
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
FT REGION 48..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 996 AA; 116410 MW; 848438D6A626E34D CRC64;
MSDSSSNNNN QDTQSVEFID KIGDHNINSF ASPDVLIKNN DLEDNYQNNA IEEFSQGNNI
DSRNESVNKV DIQSPQQDSS SEPHKIYRQQ SQDSQMMVEN IQQGDVKSNE QHEDEDENND
QKNTQIVQNN ENLGELQQEV VSCKENDQQC EKDNISQIKD DQQLQSQNEE DNTQQQQILS
IEQEQNQNQD QQLGENQHEN DSIQEKQVKE EILSQAQSQN QDSSQDADLD KQNSNQIINQ
EKIEEEKPSQ QTLLSQQENA GIQNNVQQQQ QSQQLNNNQQ DQTQNEQKQT QANQINESSI
DADTYSAQRQ YEYMMEMQKR QAEFQRQMEE LNQKYQINFR KIIDVKQESL LGNYITGLLA
IKMKYKNIDS RDQYGMTLLH NAVLGNEKEL VLFLLNNGAD VNLQDGCKRT ALMMAAHGGK
SQNNQNEEPN IKKKFDEDSE EIRKVLKLHS FNKIFKILID KGACFATKDA FQFSAMLYSV
QNQNLHILFY LIYLGANLRD ADMNGSSVVH WNAYKGNRFL MEVFHSLNLD MFTADNQGFT
PLQRSIMGIS YETVDYLARL GNPEQLPDPD ELESDGISYK IPSISIRHNL NMIKTEKQKW
YNKLFAWWSL QCSKGEELGI HPATYFFLFT AGILFYSAFR SIYNQKNYAL SQDAQISSLS
FFYNIIFFIF NFIYLAFSIR FCNTMVSYKN RNKGVYVVDD SAIDRKNQLI LEEQRNIPPY
MSRILSDKQQ FERIYQRMNF KHIDRILQDS PQFRATVNQE EELNRTTITD HADEEASVGL
TQKSAYNHLT FIHQIAILFE NNYFTSLGEV DFKRLCGSCL KYKPEKTKHC YICKVCVPYY
QFHSILFNTC ICAENHLLYL LHIFSLWVSL FMFVVVQNTN FGPMLQSWLI FKYVEIPYHI
WSKLGIFHSL IYLGVLFALF YISIYCSIEL FGIFENKTRD EILNPFEYSY NYEVIADKNR
NLVKVQKGRT TGRIEYLKVT LKAFYYRTFV HLRSKR
//
