ID W7XH22_TETTS Unreviewed; 1799 AA.
AC W7XH22;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EWS73606.1};
GN ORFNames=TTHERM_000252386 {ECO:0000313|EMBL:EWS73606.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EWS73606.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG662647; EWS73606.1; -; Genomic_DNA.
DR RefSeq; XP_012653836.1; XM_012798382.1.
DR GeneID; 24438034; -.
DR KEGG; tet:TTHERM_000252386; -.
DR eggNOG; KOG0498; Eukaryota.
DR InParanoid; W7XH22; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF5; I[[H]] CHANNEL, ISOFORM E; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
PE 4: Predicted;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 236..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1105..1131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1151..1170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1182..1206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 414..520
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1288..1394
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
SQ SEQUENCE 1799 AA; 211003 MW; F26608E508A727D3 CRC64;
MNQNQHFIYE NYMHNQYVKP FQEVNKSAEN SLSSFSSAKK NPFIKVRQVS VVDILKGDDQ
DSFQSQTKLT QNNIHQFSQN VINAQQNHVQ NTQNSQESHQ CSKIIEEEYS NTHKTDNGME
IQVDYSYNES HQRARESDNE QTVHKQSFTQ IIGQLVKKKR KNNIELEYIT SKNVWKKKWL
GILFYVSKFL YIAKQTQQLF RAALLTSFQL HLIGDAASDL DQNDNFSKLD LRIISLFLLF
AGSLFYGHLF ACLWYYVGTQ NEEGWINFNQ LDRSDIYSNY ICSYYYAVIT MTTIGYGDIT
AKTTNERFVM IFLALLSCGI FGFTINSIGN ILSDFKQKSD MYLTELGKLN KFLSYYQVST
QVQTNARKYL KFVHQEKNKD QLSTLQSLTN LSDYLQNQIK MEVISKKLKQ IHFFRNVLKE
ETILKLSLQV KESIYQPEQI ILGQNEVKEP SIYIINHGRV LKYSQYDITA KENSIVELKE
KENFGLIEFF MNTENSYFNY KSKELTSIFS IQLSSFLKII KQDNESYEKF CYIRDQVIYQ
QYLSQVNYSC LSCQSKNHTL KECPCIFYNS RKINVIKKNL QQEKEILEIK RSNKKKQNCW
ILFELNNSKA LDFQNDNINQ LSYNECSQIT DEEQDDNKGF YIQEQEIADV EPNKIIFTQN
LLKINEERDN FISHKTSEVL NEDDCSIGKI GSELKPQIMI QPRRNQIYDQ QRSDEIKKQN
SNLMEHQLDE ELSKQGQIVS LNSQKNISQT IHSSANIAQN QSQYFLQNLM QNLKDIQILL
SQNLYPQKVQ QKQGNISRRN TKRVESSNLY NFKKEYSSSL LGSNNNVKHA KSISHSLLPI
LTKHQKSIVE FEFQDEEFDK LHQFKIYYPL NNFDTSLNYE KYLPSQFSKS LQDESKNIEN
SQTSFNSGKK TPFIKIKQVS VVDILKGDDQ DSVQSFGKIT QNNINQQCHN YVYTLNQGYD
SSHTQDSQQC SKIIEEEYSI MQKTQNDPEI QVDCSKDDSN QKEKEIENEV QKQSFTQIVG
QLIKKKRKNN IELEYINSKD VWKKKWLGVL FYVSKFLYIA KQCQKVFRAS LLTSFQLHLI
GDISSDFEQN ESYSKLDLTC LLNQIGIISL FLLFAGSLFY GHLFACFWYY VGTQSEQGWI
HFNQLDINNI YSNYICSYYY AVVTMTTIGY GDITAKTDQE RFVMIFLALL SCGIFGFTIN
SIGNILSDFK QKSDMYLTEL GKLNKYLSFY QVSSQVQINA RKYLKFIHQE KNKDQLSTFQ
SLNNLSDYLQ NQIKMEVISK KLKQIKFLTN ILKEEIILQL SLQVQERIYQ PEQIILDQNE
NKEPAIYLIN HGRVLKYSQY DITAKENSIV ELKEKENFGL IEFFMNKENS NFNYKSKGIT
SIFSLELSSF LKIIKQDDES YEKFCYVKDQ IIYQQYLSQV NYFCLSCQSK NHTLKECPCI
FYNERHLSIV KKTLQQNQEL YDKKRQIKKK QNCRKLFDQI YSKAIDFQNN NINQLSFNEC
SQLTEEEDDD HEYEEQEKQN NNSKNLFIEG IEKLEAEARK SIFTQNLLKV NEEKDSFISH
KTGEVLNEDD CSIGKIASEL KPQIMIQPRR NHTYDFQKSE EMKKQNSNLI EHQQDDDFFR
HGRMISLNSQ KNVGQLNQPS ANIAQNQNSN IIQNLVQNLK EFQNFLQQNQ SSQKAPLKQG
NFNKLTTKRL DSSSIIFNIK NEHSNSLNGS NNQNKQAKQN SFTFFEAKNS NEKSQQKIQI
CEEDLDKLQL FKIYYPLSNY DLVIAHVNKS HLQFKIPQIL KNLKLKKRGE NQIRHNPIL
//
