ID W8BZ45_CERCA Unreviewed; 262 AA.
AC W8BZ45;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=(Mediterranean fruit fly) hypothetical protein {ECO:0000313|EMBL:CAD6992821.1};
DE SubName: Full=Deoxynucleoside kinase {ECO:0000313|EMBL:JAB98556.1};
GN Name=DNK {ECO:0000313|EMBL:JAB98556.1};
GN ORFNames=CCAP1982_LOCUS1660 {ECO:0000313|EMBL:CAD6992821.1};
OS Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Tephritoidea;
OC Tephritidae; Ceratitis; Ceratitis.
OX NCBI_TaxID=7213 {ECO:0000313|EMBL:JAB98556.1};
RN [1] {ECO:0000313|EMBL:JAB98556.1}
RP NUCLEOTIDE SEQUENCE.
RA Geib S.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB98556.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24495485; DOI=10.1186/1471-2164-15-98;
RA Calla B., Hall B., Hou S., Geib S.M.;
RT "A genomic perspective to assessing quality of mass-reared SIT flies used
RT in Mediterranean fruit fly (Ceratitis capitata) eradication in
RT California.";
RL BMC Genomics 15:98-98(2014).
RN [3] {ECO:0000313|EMBL:CAD6992821.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EGII {ECO:0000313|EMBL:CAD6992821.1};
RA Whitehead M.;
RL Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DCK/DGK family.
CC {ECO:0000256|ARBA:ARBA00007420}.
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DR EMBL; CAJHJT010000001; CAD6992821.1; -; Genomic_DNA.
DR EMBL; GAMC01007999; JAB98556.1; -; mRNA.
DR RefSeq; XP_004521217.1; XM_004521160.2.
DR AlphaFoldDB; W8BZ45; -.
DR EnsemblMetazoa; XM_004521160.3; XP_004521217.1; LOC101450470.
DR GeneID; 101450470; -.
DR KEGG; ccat:101450470; -.
DR OrthoDB; 5393913at2759; -.
DR Proteomes; UP000606786; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019136; F:deoxynucleoside kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01673; dNK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR002624; DCK/DGK.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR PANTHER; PTHR10513:SF35; THYMIDINE KINASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF01712; dNK; 1.
DR PIRSF; PIRSF000705; DNK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:JAB98556.1};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000606786};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 36..229
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
FT REGION 238..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 116
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-1"
FT BINDING 39..47
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT BINDING 175..179
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
SQ SEQUENCE 262 AA; 30631 MW; 30F6A90290BDC850 CRC64;
MQRLALKRIF GTMASLKPVS TSLPKYGVGS QPFTVFIEGN IGSGKTTFIE HFKKFEDKVC
AIAEPVDKWR NFKGHNLLEL MYIDPDRWAM PFQSYVMLTM LERHTQITDK PIKILERSLY
SAKYCFVENL HKSGLIHDGM YEILKQWYNY VEDITHVQAD LIVYLRTTPE VVYERIRKRA
RSEEACVPLE YIKQLHELHE DWLIRNRVGH NIKVLEIEAD LDLSEIDREY KRSESVITAT
MQQQTQRPAV TASPSKRSDY LG
//
