ID W8C6G7_CERCA Unreviewed; 2257 AA.
AC W8C6G7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=DNA polymerase zeta catalytic subunit {ECO:0000256|ARBA:ARBA00021589};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=DPOLZ {ECO:0000313|EMBL:JAC02287.1};
OS Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Tephritoidea;
OC Tephritidae; Ceratitis; Ceratitis.
OX NCBI_TaxID=7213 {ECO:0000313|EMBL:JAC02287.1};
RN [1] {ECO:0000313|EMBL:JAC02287.1}
RP NUCLEOTIDE SEQUENCE.
RA Geib S.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAC02287.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24495485; DOI=10.1186/1471-2164-15-98;
RA Calla B., Hall B., Hou S., Geib S.M.;
RT "A genomic perspective to assessing quality of mass-reared SIT flies used
RT in Mediterranean fruit fly (Ceratitis capitata) eradication in
RT California.";
RL BMC Genomics 15:98-98(2014).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
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DR EMBL; GAMC01004269; JAC02287.1; -; mRNA.
DR GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR CDD; cd05778; DNA_polB_zeta_exo; 1.
DR CDD; cd05534; POLBc_zeta; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR030559; PolZ_Rev3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR025687; Znf-C4pol.
DR PANTHER; PTHR45812; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45812:SF1; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 2.
DR Pfam; PF14260; zf-C4pol; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 2: Evidence at transcript level;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 121..212
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 1496..1600
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 1664..2114
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 2168..2235
FT /note="C4-type zinc-finger of DNA polymerase delta"
FT /evidence="ECO:0000259|Pfam:PF14260"
FT REGION 516..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 850..932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 918..932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:JAC02287.1"
SQ SEQUENCE 2257 AA; 253688 MW; CCF1E2A3D652BCAD CRC64;
FKHRIGLLFH NKLNGAVKMD DSKDHDGSVF SVRFVIADFY MEKPISGYDP CYSEFRGKEI
KRVPIIRIFG SNADGRKTCM HVHGVFPYFY IPYEAKEFES LNKAIYQISS SVDKAINISL
GQASSNVQHV FKVQLVKGIP FYGYHRAEHQ FLKIYMFNPR FVRRASNLLQ SGAVMNKNFQ
PYESHVPYIL QFMIDYNLYG MSFVYLPLDV VKFRQANESP VVEASDTNEK EEHISNQTIA
KKQTTCELEV DIGSNFILNR FQLAMRGNNT ATHSNPGIEA IWNDERLRRQ KMAQRPDVEK
VPDLELPATQ ERSNVQSTES EIFHRTVLQS KLLAIELSSN GSGSQVDQSL NFTLQTSSAN
FTLENTAEKN QSHTFNLRKI IGNAVYPEEC SPDENIVDAS FIENHLSQND FLRSSSLVLS
TNTSQEKNIT NDRGDSIFLD ETILDEELLF SSKTKSPNKI NASLCAEDEE LLDILQQLEE
QEENGCQIDL DSTLAPLTQA HKKFDPSPDL LDKQVKSAAL SQPMPESDSD SDTCDNGNLH
DFSIVLEDLD EFILKFTPTQ PTEEDDGKTD LPQMDGTDDL LPKTPTKSGH FSKSEINRNR
VTSPRTPGTA STNISPKRSP RTPKSSASKK YAPLPLKITC KKQEKSTPHI NEITPMRNSA
LRNLDLGSGS TRGTKMSLSK KLALTALRRK SVEWSPSTLN EKILISTKSA EKTKEKRTPL
RRSRRTADLE TTHITCELTP RRKSGRILKV YSIEEKEKEA TDRNKKTEHG ASTLASINQI
ASKDEGSLNK EIDFQCGKKV HIEAKNTTRD HQPAVSKTIL KSQEPKTRKC VVKISKKSMS
SRGANCLKAY ESTSKQTGNR DKSPTAVSKA ENPTEEESNG EIDSNRQGNL TEMPQISSSN
NSIADPDSSE SDEIAASDTE DASTTISAKR QRRSFHLMQH KRPLKIFNTQ TQNSNGPTAN
AIEPDKSPKE ALNISDDDCA DLDDLHIQSF YDASFTEGLS SPLNRDDNPS PIAISNQQDV
LSAQLITEDS NGSVRCFQSL GRPQNSHTEA ILSTKSNIST PNSESASSSS NRIVQITPFN
LPPTYDEVLA SCVKLDIPEY EFQKPFYGNP CDVTRMKEVG HIVLQIPGNT LNDCEEFQSV
LGNEMNGLTE WRRRKMLAIS GNSELITPSQ RNAQRIRECF AEPKRITITP QICPPTRHEA
KLWLKARQLL GNGEACSAQR KVNLDESPIK VRRQKTTMIL NDGAICDNDD DALDNSNYLT
LTPPTPIVNT KPATATKKGE LENTNKNAIE RVKSRTKRAK LSLNKKLKAC ASPQSTWVLN
DDTLPPSQLE KTAQIDGSGK IMTSNDSTVS SEAALDALKR SSFIKNLHGK ASPFSHELSF
GLNTASLNNT FGFKVNLENL QQAKSDVECN YLTTIVLELF VPTRGNLLPD PAFDEVRCLF
YAIEHRSPAG AAEDAKGLPQ NACGCIIVKD SDDGSAQEDC RMFGTGGHDD IGLRFVHTEI
EAFEALVELS KHWDPDIYGG YEIETASWGY ILERAKQLGF NMAPLLSRVP SQKVREYVDE
DREHFTDLDI ELKLCGRILL DVWRLMRSEI ALTSYTFENV MYHILHKRCP AHSHQALTAW
FEVPYTRWIV IEYYIERVRG TLALLEQLDL IGRTSEMAKL IGIQFYEVLS RGSQFRVESM
MLRIAKPRNL VPVSPSVQQR AHMRAPEYLP LILEPQSRFY SDPVIVLDFQ SLYPSMIIAY
NYCFSTCLGR VEHLGHSSPF EFGASQLRVS PSLLRRLIDD DLITISPCGV VFVKSSVREG
ILPRMLSEIL NTRQMVKQSM KLDKTNSALQ RVLHSRQLGL KLMANVTYGY TAANFSGRMP
AVEVGDSVVA KGRETLERAI RMVESNEKWR ARVVYGDTDS MFVQVPGRNR DQAFKIGEEI
AAAVTRDNPQ PVKLKLEKVY QPCILQTKKR YVGYMYETAD QAEPVYEAKG IETVRRDGCP
AVAKMLEKVL RILFETTDVS QIKQYVCRQF SKLLAGRANL QDLIFAKEFR GLKGYKPTAC
VPALELTRRW IQTDPRRIPR CGERVPFIIV NGPPGLPLIR LVRSPHEVLA DEGLKINAIY
YITKAIIPPL NRCLLLIGAD VNEWFANLPR KILLVPPVST ANKLAFTIDS AYHSKKSTIS
QYFSATNCIV DCGRQTKQGI CEDCGRQPQR TFVTLYGKMA KIERGYQLVQ QICQACCGRV
GEINCCSLDC PVLYMTEVKR RDLQQLEHMR KLLAERF
//
