ID W8CXT1_RABIT Unreviewed; 905 AA.
AC W8CXT1;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Toll like receptor 3 {ECO:0000313|EMBL:AGU70441.1};
GN Name=TLR3 {ECO:0000313|EMBL:AGU70441.1};
OS Oryctolagus cuniculus cuniculus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=568996 {ECO:0000313|EMBL:AGU70441.1};
RN [1] {ECO:0000313|EMBL:AGU70441.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Zaragoza7 {ECO:0000313|EMBL:AGU70441.1};
RX PubMed=23964588; DOI=10.1186/1471-2156-14-73;
RA Abrantes J., Areal H., Esteves P.J.;
RT "Insights into the European rabbit (Oryctolagus cuniculus) innate immune
RT system: genetic diversity of the toll-like receptor 3 (TLR3) in wild
RT populations and domestic breeds.";
RL BMC Genet. 14:73-73(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. Secreted,
CC extracellular space, extracellular matrix
CC {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KC963249; AGU70441.1; -; Genomic_DNA.
DR AlphaFoldDB; W8CXT1; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0001819; P:positive regulation of cytokine production; IEA:UniProt.
DR GO; GO:0032680; P:regulation of tumor necrosis factor production; IEA:UniProt.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR041015; TLR3_TMD.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF524; TOLL-LIKE RECEPTOR 3; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF01582; TIR; 1.
DR Pfam; PF17968; Tlr3_TMD; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 10.
DR SMART; SM00369; LRR_TYP; 15.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AGU70441.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..905
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004907411"
FT TRANSMEM 705..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 755..898
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 905 AA; 104084 MW; 4F66EA9C1AC0BE29 CRC64;
MSQSVPYHIS SLWGLLSLWM LCTSSGNKCT VRQEVADCSH LKLTQIPDDL PTNITVLNLT
HNQIKRLPPA NFTRYSRLTV LDGGFNTISK LEPELCQSLP LLKVLNLQHN ELSQLSDKTF
VFCMNLTELH LMSNSIQKIQ NNPFKNQKNL IKLDLSHNGL KSTKLGTQLQ LQNLQELLLS
KNKIQALKSE ELAFLGNSSL KKLELSSNLI KEFSPGCFHA IGQLFGLFLN NAQLGPSLIE
KLCLELSNTS IQNLSLSNSQ LNRISNRTLL GLKHTNLTML DLSHNNLNMI DDDSFVWLPH
LKYLFLEYNN IVHLSNHSFY GLFNVRHLNL KRSFPKQSVS LTSLPKIDDF SFQWLRCLEY
LNMEDNDIPS IKRNMFTGLI NLRYLSLSNS FTNLRTLKNE TFSSLAHSPL LILNLTKNKI
SKIESDAFSW LGSLEVLDIG INEIGQELTG QEWRGLENIF EIYLSYNKYL QLTSNSFALV
PSLQRLMLRR VALKNVDISP SPFHPLHDLT ILDLSNNNLA NINEEMLEGL EKLEVLDLQH
NNLARLWKQA NPGGPVHFLE GLSHLHTLNL ESNGFDEIPE GVFKNLFQLK SINLALNNLN
VLPQSVFDDQ VSLKSLNLQK NLITSVEKKV FGPVFKNLSN LDMSFNPFDC TCESIAWFVN
WINKTRTNIS ELSSHYLCNT PPQYHGFSVR LFDTSSCKDS APFELLFMIN TSFLLLFIFI
VLLIHFEGWR ISFYWNVSVH RILGFKEIDG QPEQFEYTAY IIHAYKDRDW VWEHFSSMEE
EDPSIKFCLE ERDFQAGVLG LEAIVNSIKR SRKIIFVITQ HLLKDPLCKR FKVHHAVQQA
IEQNLDSIIL IFLENIPDYK LNHALCLRRG MFKSRCIFYW PVHKERIEAF HHKLQVALGS
RNSLH
//
