ID W8G106_ORENI Unreviewed; 958 AA.
AC W8G106;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Receptor protein TLR22 {ECO:0000313|EMBL:AHK13950.1};
DE Flags: Fragment;
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|EMBL:AHK13950.1};
RN [1] {ECO:0000313|EMBL:AHK13950.1}
RP NUCLEOTIDE SEQUENCE.
RA Pang J.C., Gao F.Y., Lu M.X.;
RT "Cloning and expression analysis of TLR21 and 22.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KJ010825; AHK13950.1; -; Genomic_DNA.
DR AlphaFoldDB; W8G106; -.
DR SMR; W8G106; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF551; LOW QUALITY PROTEIN: TOLL-LIKE RECEPTOR 13-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00364; LRR_BAC; 3.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AHK13950.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 766..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 798..939
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AHK13950.1"
SQ SEQUENCE 958 AA; 110169 MW; 4BC922923F2DDAB7 CRC64;
KEEQNVANHA LFFTCCKSCI IFYMLCIINF IAPVDGFSLK TCKISYSTAI CIGSKLRAVP
GDIPSTVTGL DLSSNRISTI NASDFNNLVN LTKLDLNINN ISQIESAAFA NQSSLKTLNL
NNNKLVTLGE NVFDGLSRLI ELRINKNHIK QVASTSFKSM TSLKLLDISH NKLHHITKVQ
LILQHLPHLR ELVISNNDLS TFQSFELTNK SLELQYLDLS KNPLAVFRIT ADVFPNLTWF
KIGSPARKKQ MIWDVQNKTF LSRVTTLDIS ELHLGLGDME RLLESVNSSL AILRMNAMTH
NLTALINISC TIPTMRTLQL RSNKLSFVNA YLFKLCINVT ELVLTDNKIK YTHDDAFRSL
KNLRILTLSK NRPPLVPAAT RNLPSLSELD LSTNNISTLD CHDFTNQTKL RKLYLYQNSI
TALKPCLFKD LKGLETLKLQ TNQITKLNGA FKEHLPKLTQ LHLNGNKLTA IKKDAFKGLH
SLQNLSLHQN EIKVLESKSF SGLTNLTQIN LQNNDISQDE LNKDVFSPLI NLRRLDLSEN
HINYKKSRNL PDPPFSQLSH LEELLVFSQH HRLHSYLPVN FLQGLTNLLS FKARNIRIAS
LDKDTFVYTP QLQLLELSSN ELKELPPDLF FPIPNLKSLY ISRTGLYSLD FLIDAKLTKL
EFLQARQNLY SVIRREYIKS LPALTYLDLQ GNGFTCNCDN KWFLSWAIND SKTQVYDAYN
FTCNYPQEFK SKKLLDLDTS SCLDNTDFIC FLCTTCTILC FMVVSFTYHF MGLQLVYAYY
LFIAWLFDKK HKNKKTPHQY DAFISYNTHD EPWVIDKLLP KLEGEQGWRL CLHHRDFEPG
RPIIDNITDA IYGSRKTICV ISRKYLESEW CSREIQTASF RLFDEQTDVL ILVFMEEIPS
YLLSPYHRMR KMLKKKTYLS WPRAGEHSEL FWEKLCQALE TREDPEAKTL LLTVPTMP
//
