ID W8QMQ6_9HIV1 Unreviewed; 156 AA.
AC W8QMQ6;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AHL45871.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AHL45871.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AHL45871.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=D022995 {ECO:0000313|EMBL:AHL45871.1};
RX PubMed=24595023;
RA Grabowski M.K., Lessler J., Redd A.D., Kagaayi J., Laeyendecker O.,
RA Ndyanabo A., Nelson M.I., Cummings D.A., Bwanika J.B., Mueller A.C.,
RA Reynolds S.J., Munshaw S., Ray S.C., Lutalo T., Manucci J., Tobian A.A.,
RA Chang L.W., Beyrer C., Jennings J.M., Nalugoda F., Serwadda D., Wawer M.J.,
RA Quinn T.C., Gray R.H.;
RT "The Role of Viral Introductions in Sustaining Community-Based HIV
RT Epidemics in Rural Uganda: Evidence from Spatial Clustering, Phylogenetics,
RT and Egocentric Transmission Models.";
RL PLoS Med. 11:E1001610-E1001610(2014).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KJ374044; AHL45871.1; -; Genomic_DNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Viral envelope protein {ECO:0000313|EMBL:AHL45871.1};
KW Virion {ECO:0000313|EMBL:AHL45871.1}.
FT DOMAIN 3..155
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AHL45871.1"
FT NON_TER 156
FT /evidence="ECO:0000313|EMBL:AHL45871.1"
SQ SEQUENCE 156 AA; 18301 MW; 6D81FEC6B50F476B CRC64;
STMGAASITL TVQARQLLTG IVQQQSNLLR AIEAQQHLLK LTVWGIKQLQ ARILAVERYL
KDQQLLGIWG CSGKLICTTN VPWNSSWSNK SQGEIWENMT WLQWDREISN YTDIIYSLLE
ESQNQQEKNE QDLLSLDKWA SLWNWFDITN WLWYIK
//
