ID W8R6W2_9HIV1 Unreviewed; 156 AA.
AC W8R6W2;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AHL46165.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AHL46165.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AHL46165.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=G056769 {ECO:0000313|EMBL:AHL46165.1};
RX PubMed=24595023;
RA Grabowski M.K., Lessler J., Redd A.D., Kagaayi J., Laeyendecker O.,
RA Ndyanabo A., Nelson M.I., Cummings D.A., Bwanika J.B., Mueller A.C.,
RA Reynolds S.J., Munshaw S., Ray S.C., Lutalo T., Manucci J., Tobian A.A.,
RA Chang L.W., Beyrer C., Jennings J.M., Nalugoda F., Serwadda D., Wawer M.J.,
RA Quinn T.C., Gray R.H.;
RT "The Role of Viral Introductions in Sustaining Community-Based HIV
RT Epidemics in Rural Uganda: Evidence from Spatial Clustering, Phylogenetics,
RT and Egocentric Transmission Models.";
RL PLoS Med. 11:E1001610-E1001610(2014).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; KJ374397; AHL46165.1; -; Genomic_DNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Viral envelope protein {ECO:0000313|EMBL:AHL46165.1};
KW Virion {ECO:0000313|EMBL:AHL46165.1}.
FT DOMAIN 3..155
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AHL46165.1"
FT NON_TER 156
FT /evidence="ECO:0000313|EMBL:AHL46165.1"
SQ SEQUENCE 156 AA; 18283 MW; E1F1EEBDBD1C19C0 CRC64;
STMGAASITL TVQARLLLSG IVQQQSNLLR AIEAQQHLLK LTVWGIKQLQ ARVLAVERYL
KDQQLLGIWG CSGKLICTTN VPWNSSWSNK SQTEIWENMT WLQWDKEISN YTQIIYNLIE
ESQIQQEKNE QDLLALDKWA SLWNWFDISN WLWYIK
//
