ID W8SJ48_9RHOB Unreviewed; 442 AA.
AC W8SJ48;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:AHM02515.1};
DE EC=1.1.1.35 {ECO:0000313|EMBL:AHM02515.1};
GN ORFNames=roselon_00048 {ECO:0000313|EMBL:AHM02515.1};
OS Roseibacterium elongatum DSM 19469.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Roseibacterium.
OX NCBI_TaxID=1294273 {ECO:0000313|EMBL:AHM02515.1, ECO:0000313|Proteomes:UP000019593};
RN [1] {ECO:0000313|EMBL:AHM02515.1, ECO:0000313|Proteomes:UP000019593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19469 {ECO:0000313|Proteomes:UP000019593};
RA Fiebig A., Goeker M., Klenk H.-P.P.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP004372; AHM02515.1; -; Genomic_DNA.
DR RefSeq; WP_025310463.1; NZ_CP004372.1.
DR AlphaFoldDB; W8SJ48; -.
DR STRING; 1294273.roselon_00048; -.
DR KEGG; red:roselon_00048; -.
DR PATRIC; fig|1294273.3.peg.42; -.
DR eggNOG; COG0824; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_578448_0_0_5; -.
DR OrthoDB; 9803287at2; -.
DR Proteomes; UP000019593; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR CDD; cd00586; 4HBT; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF1; LAMBDA-CRYSTALLIN HOMOLOG; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF13279; 4HBT_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:AHM02515.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019593}.
FT DOMAIN 4..172
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 178..222
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT REGION 225..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 47552 MW; 895C962D79B24A1B CRC64;
MTGQVGIIGA GPIGAGWAAR FALMGWTVRV FDPAQDCKPS VLATLERARA SLPALYDMPL
PPEGPVSHHA DLADVIRNAD WIQLGPSEES SEIDHILQKV LEHRSPDMIV ASSTAVPSSS
GLASGQILVA QPRDPVYLIP LVELTVSSQT PALHLARAEK TLRALGMAPV VTATERPGQV
ADRLQAALVQ EAQQLVAEGG ATSRQIEDAI RLGLGLRWMQ AGLEDDGAHA PDTDASTRAP
AGVDVDPEGH RNDVLLSLLR VLKDRGDGAG AVLRDHEATL GLTVPDPGCS DMPVTLDRQV
PITWVDYNGH MNEARFLQAF SNACDQLLEW AGMTPEAIAA GHSVFTVETH LRHLDEVQIG
DRIRVTARVL EGGGKKFHIW QELRVGENLC STCEQLLLHV DLKTRRSAPP PEAIATWLRR
AMEAQAEMPV PQGLGRAVAQ RS
//
