ID W8U6A9_STAAU Unreviewed; 454 AA.
AC W8U6A9; A0A0D1H610;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=DNA repair protein RadA {ECO:0000256|HAMAP-Rule:MF_01498, ECO:0000256|RuleBase:RU003555};
GN Name=radA {ECO:0000256|HAMAP-Rule:MF_01498,
GN ECO:0000313|EMBL:CRI07825.1};
GN ORFNames=BN1321_130010 {ECO:0000313|EMBL:CRI07825.1}, CRI62_05955
GN {ECO:0000313|EMBL:PHP55344.1}, CV021_09525
GN {ECO:0000313|EMBL:PPJ73890.1}, G6W63_01300
GN {ECO:0000313|EMBL:NGW86336.1}, G6Y24_15070
GN {ECO:0000313|EMBL:NGW68772.1}, GO782_08160
GN {ECO:0000313|EMBL:MVH48594.1}, GO793_13165
GN {ECO:0000313|EMBL:MVI56800.1}, GO852_12685
GN {ECO:0000313|EMBL:MVK03774.1}, GO941_15810
GN {ECO:0000313|EMBL:MVL46904.1}, GZ067_07165
GN {ECO:0000313|EMBL:QID97464.1}, GZ156_05680
GN {ECO:0000313|EMBL:NDQ60025.1}, M1K003_1987
GN {ECO:0000313|EMBL:GBV20985.1}, NCTC6133_00617
GN {ECO:0000313|EMBL:SUK33447.1}, NCTC7972_01410
GN {ECO:0000313|EMBL:SUK17890.1}, QU38_09645
GN {ECO:0000313|EMBL:KIT96097.1}, SA0759_02501
GN {ECO:0000313|EMBL:QLH97245.1}, SA950122_02441
GN {ECO:0000313|EMBL:QLH99895.1}, SAJPND4_00516
GN {ECO:0000313|EMBL:BAR10752.1}, SAMEA70153168_02292
GN {ECO:0000313|EMBL:CAC8250186.1};
OS Staphylococcus aureus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1280 {ECO:0000313|EMBL:CRI07825.1, ECO:0000313|Proteomes:UP000039437};
RN [1] {ECO:0000313|Proteomes:UP000061420}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TMUS2134 {ECO:0000313|Proteomes:UP000061420};
RA Yamaguchi T., Suzuki S., Okumura S., Miura Y., Tsukimori A., Nakamura I.,
RA Ito N., Shiina T., Matsumoto T.;
RT "Evolution of mutations in Methicillin-Resistant Staphylococcus aureus ST72
RT clinical isolates with reduced susceptibility to vancomycin and daptomycin
RT by complete genome sequence analysis.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BAR10752.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TMUS2134 {ECO:0000313|EMBL:BAR10752.1};
RA Yamaguchi T., Suzuki S., Okamura S., Miura Y., Tsukimori A., Nakamura I.,
RA Ito N., Masuya A., Shiina T., Matsumoto T.;
RT "Evolution and Single-Nucleotide Polymorphisms in Methicillin-Resistant
RT Staphylococcus aureus Strains with Reduced Susceptibility to Vancomycin and
RT Daptomycin, Based on Determination of the Complete Genome.";
RL Antimicrob. Agents Chemother. 59:3585-3587(2015).
RN [3] {ECO:0000313|EMBL:KIT96097.1, ECO:0000313|Proteomes:UP000032274}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SA-120 {ECO:0000313|EMBL:KIT96097.1,
RC ECO:0000313|Proteomes:UP000032274};
RA Crovadore J., Chablais R., Tonacini J., Schnyder B., Lefort F.;
RT "Characterization of Swiss Staphylococcus aureus strains involved in food
RT poisoning.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CRI07825.1, ECO:0000313|Proteomes:UP000039437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AH1 {ECO:0000313|EMBL:CRI07825.1,
RC ECO:0000313|Proteomes:UP000039437};
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Proteomes:UP000265645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M1K003 {ECO:0000313|Proteomes:UP000265645};
RA Nakamura Y., Takahashi H., Takaya A., Inoue Y., Katayama Y., Kusuya Y.,
RA Shoji T., Takada S., Nakagawa S., Oguma R., Ozawa N., Yamaide F.,
RA Suzuki S., Villaruz A., Otto M., Matsue H., Nunez G., Shimojo N.;
RT "Protection against atopic dermatitis through acquisition of Staphylococcus
RT quorum-sensing agr mutations in the skin.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:PHP55344.1, ECO:0000313|Proteomes:UP000221735}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SR411 {ECO:0000313|EMBL:PHP55344.1,
RC ECO:0000313|Proteomes:UP000221735};
RA Chen Y.;
RT "Methicillin-resistant Staphylococcus aureus of sequence type 398
RT isolates.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:PPJ73890.1, ECO:0000313|Proteomes:UP000238775}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G703N2B1 {ECO:0000313|EMBL:PPJ73890.1,
RC ECO:0000313|Proteomes:UP000238775};
RA Founou R.C., Founou L., Allam M., Ismail A., Essack S.Y.;
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|Proteomes:UP000254224, ECO:0000313|Proteomes:UP000255091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC6133 {ECO:0000313|EMBL:SUK33447.1,
RC ECO:0000313|Proteomes:UP000255091}, and NCTC7972
RC {ECO:0000313|EMBL:SUK17890.1, ECO:0000313|Proteomes:UP000254224};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:GBV20985.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M1K003 {ECO:0000313|EMBL:GBV20985.1};
RA Nakamura Y., Takahashi H., Takaya A., Inoue Y., Katayama Y., Kusuya Y.,
RA Shoji T., Takada S., Nakagawa S., Oguma R., Ozawa N., Yamaide F.,
RA Suzuki S., Villaruz A., Otto M., Matsue H., Nunez G., Shimojo N.;
RT "Protection against atopic dermatitis through acquisition of Staphylococcus
RT quorum-sensing agr mutations in the skin.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|Proteomes:UP000509140, ECO:0000313|Proteomes:UP000510613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=07-059 {ECO:0000313|EMBL:QLH97245.1,
RC ECO:0000313|Proteomes:UP000510613}, and 950122
RC {ECO:0000313|EMBL:QLH99895.1, ECO:0000313|Proteomes:UP000509140};
RA Cortes M.F., Botelho A.M.N., Bandeira P.T., Mouton W., Badiou C., Bess M.,
RA Lima N.C.B., Soares A.E.R., Souza R.C., Almeida L.G.P., Vasconcelos A.T.R.,
RA Nicolas M.F., Vandenesch F., Laurent F., Planet P., Figueiredo A.M.S.;
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|Proteomes:UP000430661, ECO:0000313|Proteomes:UP000433366}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S_2023.LVRQ.AN {ECO:0000313|EMBL:MVL46904.1,
RC ECO:0000313|Proteomes:UP000434412}, S_2078.LLFX.AN
RC {ECO:0000313|EMBL:MVK03774.1, ECO:0000313|Proteomes:UP000430661},
RC S_3122.LTHB.DN {ECO:0000313|EMBL:MVH48594.1,
RC ECO:0000313|Proteomes:UP000442194}, and S_4031.LGMP.AI
RC {ECO:0000313|EMBL:MVI56800.1, ECO:0000313|Proteomes:UP000433366};
RA Stine O.C.;
RT "Implementation of targeted gown and glove precautions to prevent
RT Staphylococcus aureus acquisition in community-based nursing homes.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:NDQ60025.1, ECO:0000313|Proteomes:UP000462022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=67-013 {ECO:0000313|EMBL:NDQ60025.1,
RC ECO:0000313|Proteomes:UP000462022};
RA Little S.V., Hillhouse A.E., Cohen N.D., Lawhon S.D., Bryan L.K.;
RT "Analysis of Virulence and Antimicrobial Resistance Gene Carriage in
RT Staphylococcus aureus Infections in Equids Using Whole Genome Sequencing.";
RL Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|Proteomes:UP000473113, ECO:0000313|Proteomes:UP000478593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UA786 {ECO:0000313|EMBL:NGW86336.1,
RC ECO:0000313|Proteomes:UP000478593}, and UG255
RC {ECO:0000313|EMBL:NGW68772.1, ECO:0000313|Proteomes:UP000473113};
RA Castro-Cardozo B., Berrio M., Vargas M.L., Carvajal L.P., Millan L.V.,
RA Rios R., Hernandez A., Rincon S.L., Cubides P., Forero E., Dinh A.,
RA Seas C., Munita J.M., Arias C.A., Reyes J., Diaz L.;
RT "Detection of Heterogeneous Vancomycin Intermediate Resistance in
RT Methicillin Resistant Staphylococcus aureus Isolates from Latin-America.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|EMBL:QID97464.1, ECO:0000313|Proteomes:UP000501532}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SA1428 {ECO:0000313|EMBL:QID97464.1,
RC ECO:0000313|Proteomes:UP000501532};
RA Lippolis J.;
RT "DNA sequencing of a Staphylococcus aureus strain isolated from an
RT intramammary infection in a dairy cow.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [15] {ECO:0000313|EMBL:CAC8250186.1, ECO:0000313|Proteomes:UP000507402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MOS114 {ECO:0000313|EMBL:CAC8250186.1,
RC ECO:0000313|Proteomes:UP000507402};
RG Pathogen Informatics;
RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent ATPase involved in processing of recombination
CC intermediates, plays a role in repairing DNA breaks. Stimulates the
CC branch migration of RecA-mediated strand transfer reactions, allowing
CC the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA
CC in the presence of ADP but not other nucleotides, has ATPase activity
CC that is stimulated by ssDNA and various branched DNA structures, but
CC inhibited by SSB. Does not have RecA's homology-searching function.
CC {ECO:0000256|RuleBase:RU003555}.
CC -!- FUNCTION: Plays a role in repairing double-strand DNA breaks, probably
CC involving stabilizing or processing branched DNA or blocked replication
CC forks. {ECO:0000256|HAMAP-Rule:MF_01498}.
CC -!- DOMAIN: The middle region has homology to RecA with ATPase motifs
CC including the RadA KNRFG motif, while the C-terminus is homologous to
CC Lon protease. {ECO:0000256|HAMAP-Rule:MF_01498}.
CC -!- SIMILARITY: Belongs to the RecA family. RadA subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01498, ECO:0000256|RuleBase:RU003555}.
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DR EMBL; AP014653; BAR10752.1; -; Genomic_DNA.
DR EMBL; CAIIGN010000009; CAC8250186.1; -; Genomic_DNA.
DR EMBL; CVOQ01000005; CRI07825.1; -; Genomic_DNA.
DR EMBL; BDVT01000010; GBV20985.1; -; Genomic_DNA.
DR EMBL; JXIG01000628; KIT96097.1; -; Genomic_DNA.
DR EMBL; WPRT01000128; MVH48594.1; -; Genomic_DNA.
DR EMBL; WPRH01000687; MVI56800.1; -; Genomic_DNA.
DR EMBL; WPUV01000044; MVK03774.1; -; Genomic_DNA.
DR EMBL; WPVZ01000853; MVL46904.1; -; Genomic_DNA.
DR EMBL; JAAFKS010000008; NDQ60025.1; -; Genomic_DNA.
DR EMBL; JAALTR010000370; NGW68772.1; -; Genomic_DNA.
DR EMBL; JAALUV010000003; NGW86336.1; -; Genomic_DNA.
DR EMBL; PDFB01000005; PHP55344.1; -; Genomic_DNA.
DR EMBL; PGWZ01000395; PPJ73890.1; -; Genomic_DNA.
DR EMBL; CP048431; QID97464.1; -; Genomic_DNA.
DR EMBL; CP045439; QLH97245.1; -; Genomic_DNA.
DR EMBL; CP045441; QLH99895.1; -; Genomic_DNA.
DR EMBL; UHAI01000002; SUK17890.1; -; Genomic_DNA.
DR EMBL; UHAP01000001; SUK33447.1; -; Genomic_DNA.
DR RefSeq; WP_001085219.1; NZ_WYDB01000005.1.
DR MEROPS; S16.A04; -.
DR KEGG; sams:NI36_02615; -.
DR KEGG; saud:CH52_03125; -.
DR PATRIC; fig|1280.10758.peg.485; -.
DR OMA; SPKWLGK; -.
DR Proteomes; UP000032274; Unassembled WGS sequence.
DR Proteomes; UP000039437; Unassembled WGS sequence.
DR Proteomes; UP000061420; Chromosome.
DR Proteomes; UP000221735; Unassembled WGS sequence.
DR Proteomes; UP000238775; Unassembled WGS sequence.
DR Proteomes; UP000254224; Unassembled WGS sequence.
DR Proteomes; UP000255091; Unassembled WGS sequence.
DR Proteomes; UP000265645; Unassembled WGS sequence.
DR Proteomes; UP000430661; Unassembled WGS sequence.
DR Proteomes; UP000433366; Unassembled WGS sequence.
DR Proteomes; UP000434412; Unassembled WGS sequence.
DR Proteomes; UP000442194; Unassembled WGS sequence.
DR Proteomes; UP000462022; Unassembled WGS sequence.
DR Proteomes; UP000473113; Unassembled WGS sequence.
DR Proteomes; UP000478593; Unassembled WGS sequence.
DR Proteomes; UP000501532; Chromosome.
DR Proteomes; UP000507402; Unassembled WGS sequence.
DR Proteomes; UP000509140; Chromosome.
DR Proteomes; UP000510613; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0000725; P:recombinational repair; IEA:UniProtKB-UniRule.
DR CDD; cd01121; RadA_SMS_N; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_01498; RadA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR004504; DNA_repair_RadA.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR041166; Rubredoxin_2.
DR NCBIfam; TIGR00416; sms; 1.
DR PANTHER; PTHR32472; DNA REPAIR PROTEIN RADA; 1.
DR PANTHER; PTHR32472:SF10; DNA REPAIR PROTEIN RADA-LIKE PROTEIN; 1.
DR Pfam; PF13481; AAA_25; 1.
DR Pfam; PF13541; ChlI; 1.
DR Pfam; PF18073; Rubredoxin_2; 1.
DR PRINTS; PR01874; DNAREPAIRADA.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS50162; RECA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01498,
KW ECO:0000256|RuleBase:RU003555};
KW DNA damage {ECO:0000256|HAMAP-Rule:MF_01498,
KW ECO:0000256|RuleBase:RU003555};
KW DNA repair {ECO:0000256|HAMAP-Rule:MF_01498,
KW ECO:0000256|RuleBase:RU003555};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01498,
KW ECO:0000256|RuleBase:RU003555}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_01498}; Methyltransferase {ECO:0000313|EMBL:CRI07825.1};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01498,
KW ECO:0000256|RuleBase:RU003555};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_01498}; Transferase {ECO:0000313|EMBL:CRI07825.1};
KW Zinc {ECO:0000256|RuleBase:RU003555};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU003555}.
FT DOMAIN 66..214
FT /note="RecA family profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50162"
FT REGION 350..454
FT /note="Lon-protease-like"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01498"
FT MOTIF 251..255
FT /note="RadA KNRFG motif"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01498"
FT BINDING 95..102
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01498"
SQ SEQUENCE 454 AA; 49835 MW; AAB75DE6325C2C35 CRC64;
MAKKKVIFEC MACGYQSPKW MGKCPNCGAW NQMEEIVEKA ANPKHGVKTK ELAGKVQKLN
SIKHETTPRV LTDSAEFNRV LGGGIVSGSL VLIGGDPGIG KSTLLLQICA SLSQKKKVLY
ITGEESLSQT KLRAERLDED SSELQVLAET DLEVIYQTVK EEQPDLLVVD SIQTIYHPEI
SSAPGSVSQV RESTQSLMNI AKQMNIATFI VGHVTKEGQI AGPRLLEHMV DTVLYFEGDE
HHAYRILRAV KNRFGSTNEM GIFEMKQSGL KGVNNPSEMF LEERSTNVPG STIVATMEGT
RPLLIEVQAL VTPTTFNNPR RMATGIDHNR LSLLMAVLEK KENYLLQQQD AYIKVAGGVK
LTEPAVDLSV IVATASSFKD KAVDGLDCYI GEVGLTGEVR RVSRIEQRVQ EAAKLGFKRV
IIPKNNIGGW TYPEGIQVIG VTTVHEALSF ALHS
//