ID W8VUV0_BOMMO Unreviewed; 1156 AA.
AC W8VUV0;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Transient receptor potential A1 {ECO:0000313|EMBL:BAO53211.1};
GN Name=trpA1 {ECO:0000313|EMBL:BAO53211.1};
GN Synonyms=101744290 {ECO:0000313|EnsemblMetazoa:NP_001296525.1}, TRPA1
GN {ECO:0000313|EMBL:BAO53207.1};
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091 {ECO:0000313|EMBL:BAO53211.1};
RN [1] {ECO:0000313|Proteomes:UP000005204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=p50T {ECO:0000313|Proteomes:UP000005204};
RX PubMed=19121390; DOI=10.1016/j.ibmb.2008.11.004;
RG International Silkworm Genome Consortium;
RT "The genome of a lepidopteran model insect, the silkworm Bombyx mori.";
RL Insect Biochem. Mol. Biol. 38:1036-1045(2008).
RN [2] {ECO:0000313|EMBL:BAO53211.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Kosetsu {ECO:0000313|EMBL:BAO53211.1}, and N4
RC {ECO:0000313|EMBL:BAO53207.1};
RC TISSUE=Brain-subesophageal ganglion complex
RC {ECO:0000313|EMBL:BAO53207.1}, and Pupal brain-subesophageal ganglion
RC complex and egg in stage 21 {ECO:0000313|EMBL:BAO53211.1};
RX PubMed=24639527; DOI=10.1073/pnas.1322134111;
RA Sato A., Sokabe T., Kashio M., Yasukochi Y., Tominaga M., Shiomi K.;
RT "Embryonic thermosensitive TRPA1 determines transgenerational diapause
RT phenotype of the silkworm, Bombyx mori.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:E1249-E1255(2014).
RN [3] {ECO:0000313|EnsemblMetazoa:NP_001296525.1}
RP IDENTIFICATION.
RC STRAIN=p50T (Dazao) {ECO:0000313|EnsemblMetazoa:NP_001296525.1};
RG EnsemblMetazoa;
RL Submitted (JUN-2022) to UniProtKB.
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DR EMBL; AB243445; BAO53207.1; -; mRNA.
DR EMBL; AB703646; BAO53211.1; -; mRNA.
DR RefSeq; NP_001296525.1; NM_001309596.1.
DR AlphaFoldDB; W8VUV0; -.
DR SMR; W8VUV0; -.
DR EnsemblMetazoa; NM_001309596.1; NP_001296525.1; LOC101744290.
DR GeneID; 101744290; -.
DR KEGG; bmor:101744290; -.
DR OrthoDB; 2910129at2759; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0034703; C:cation channel complex; IEA:UniProt.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR PANTHER; PTHR47143; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS; 1.
DR PANTHER; PTHR47143:SF3; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS; 1.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00248; ANK; 15.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 7.
DR PROSITE; PS50088; ANK_REPEAT; 9.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:BAO53211.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005204};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 730..752
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 793..812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 833..851
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 857..877
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 897..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 971..994
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 73..105
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 106..138
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 249..281
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 320..352
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 353..385
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 426..458
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 495..527
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 527..547
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 561..593
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 738..1004
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1118..1156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1156 AA; 131336 MW; 05AB8AE1F77C41CD CRC64;
MGSFNQSRRL KNLQNLKSGA MKLPRHWSKM LGLVNISKAT IEELFQAAES GNVDDFMRLY
LSEPSRLAVR DGRGRTAAHQ ASARNNTNIL HFINNYAGDL NAKDNAGNTP LHVAVENEAL
DAIEYLLQQH VETSVLNEKC QAPIHMATEL NKVSVLQVFA KYKSLFNVNQ GGEHGRTALH
FAAIHDHDLC AKILITDLDA EWKKPCNNGY YPIHEAAKNA SSRTIEVFLQ WGEQRGCTRE
QMISLYDNEG NVPLHSAVHG GDIKAVELCL RSGAKISTQQ HDLSTPVHLA CAQGALDIVK
LMFTMQPKEK HACLTSCDVQ KMTPIHCAAM FDLPEIVNYL INEGSDINPL DKERRSPLLL
AASRAGWRTV HTLIRLGADI QLKDINSRNV LHLVVMNGGR LEDFAASCKD HCEKSLLQLL
NEKDNTGCSP LHYASREGHI RSLENLIRLG ACINLKNNNN ESPLHFAARY GRFHTACQLL
DSDKGTFIIN ESDGEGLTPL HIASREGHTR VVHLLLNRGA LLHRDHNGRN PLHLAAMSGY
TKTIELLHSV HSHLLDQIDK DGNTSLHLAT MENKPSSIAL LLSMGCRLSY NNMDMSAIDY
AIYYKFPEAA LAMVTHEQRA KEVMALRSDR HPCVTLALIA YMPRVFEAVQ DKCITKANCK
KDSKSFYIKY SFEALCPQLM DEDGTRKSQQ AQQIPLPALN AMVAHGRVEL LAHPLSQKYL
QMKWNSYGKY FHLVNVLFYC IFLIFVTVYS YLLMEHVNPI NKRERSRVGD VYYNYTATNR
TQTNWDIDAD FEAILIMYTS SVVIMVYISV CMMREAYNLK QQKWHYIVDP SNLVSWTLYI
SATITVFPTL YGHYSNYQFS AASITVFLSW FELLLLLQRF DQVGIYVVMF LEILQTLIKV
LMVFSILIIA FGLAFYILLS KGNHLSFSNI PIALMRTFAM MLGELDFVGT YVQPYYKDDS
DIILPFPIPT FIILALFMIL MPILLMNLLI GLAVGDIESV RRNAQLKRLA MQVVLHTELE
RKLPAFLLEK VDKLELIEYP NNKKCKLGFL DLILHKWFCN PFTEDTGLDL VLENNDDYVT
EQMEKQKRKF REMQNVLDQQ YLLLRLIVQK MEIKTEADDV DEGVSPNDTK VVPRWSSHRN
RKKLHSARAA SFNKST
//
