ID   W8VZI4_9FLAO            Unreviewed;       517 AA.
AC   W8VZI4;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=aldehyde dehydrogenase (NAD(+)) {ECO:0000256|ARBA:ARBA00024226};
DE            EC=1.2.1.3 {ECO:0000256|ARBA:ARBA00024226};
GN   ORFNames=NMS_0622 {ECO:0000313|EMBL:BAO54631.1};
OS   Nonlabens marinus S1-08.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Nonlabens.
OX   NCBI_TaxID=1454201 {ECO:0000313|EMBL:BAO54631.1, ECO:0000313|Proteomes:UP000031760};
RN   [1] {ECO:0000313|EMBL:BAO54631.1, ECO:0000313|Proteomes:UP000031760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S1-08 {ECO:0000313|EMBL:BAO54631.1,
RC   ECO:0000313|Proteomes:UP000031760};
RX   PubMed=24706784; DOI=10.1073/pnas.1403051111;
RA   Yoshizawa S., Kumagai Y., Kim H., Ogura Y., Hayashi T., Iwasaki W.,
RA   DeLong E.F., Kogure K.;
RT   "Functional characterization of flavobacteria rhodopsins reveals a unique
RT   class of light-driven chloride pump in bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:6732-6737(2014).
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; AP014548; BAO54631.1; -; Genomic_DNA.
DR   RefSeq; WP_041495336.1; NZ_AP014548.1.
DR   AlphaFoldDB; W8VZI4; -.
DR   STRING; 1454201.NMS_0622; -.
DR   HOGENOM; CLU_005391_1_2_10; -.
DR   OrthoDB; 9762913at2; -.
DR   Proteomes; UP000031760; Chromosome.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR   CDD; cd07130; ALDH_F7_AASADH; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR044638; ALDH7A1-like.
DR   PANTHER; PTHR43521; ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43521:SF1; ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345}.
FT   DOMAIN          38..498
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        269
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   517 AA;  55567 MW;  62735BF6125A845B CRC64;
     MSEIAKAFAI NDALKQLGVE KINKGTSTGN ENFGNGAEII SSSPVDGAEI ARVTTTTADD
     YDKVVAAAQT AFKDWRLKPA PLRGEVVRQF GDELRRLKEP LGKLVSYEMG KSYQEGLGEV
     QEMIDICDFA VGLSRQLHGL TMHSERPGHR MYEQYHPLGI VGIISAFNFP VAVWAWNTAL
     AWVCGDVCIW KPSEKTPLTG IACQNIIAKV LKDNNLPEGI SCLVNGDYKV GEMMTTDKRV
     PLISATGSTR MGKIVASKVG ERLGKSLLEL GGNNAIIVTP DADIKMTVIG AVFGAVGTAG
     QRCTSTRRLI VHDSMYDKVK TAVVDAYKQL KIGNPLDENN HVGPLIDKDA VKGYQNALTK
     VVEEGGKVIV EGGVLEGKGF ESGCYVKPAI AEAENSFEIV QHETFAPVLY LLKYSGNVEN
     ALDLQNGVNQ GLSSAIMTNN LREAEHFLSV AGSDCGIANV NIGTSGAEIG GAFGGEKDTG
     GGRESGSDAW KIYMRRQTNT INYTTELPLA QGIKFDL
//