ID W9BD52_KLEPN Unreviewed; 311 AA.
AC W9BD52; A0A0J2G4K0; A0A4V0HKH6;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Aspartate carbamoyltransferase {ECO:0000256|HAMAP-Rule:MF_00001};
DE EC=2.1.3.2 {ECO:0000256|HAMAP-Rule:MF_00001};
DE AltName: Full=Aspartate transcarbamylase {ECO:0000256|HAMAP-Rule:MF_00001};
DE Short=ATCase {ECO:0000256|HAMAP-Rule:MF_00001};
GN Name=pyrB {ECO:0000256|HAMAP-Rule:MF_00001,
GN ECO:0000313|EMBL:MUA40344.1};
GN ORFNames=B5L96_30770 {ECO:0000313|EMBL:OVF62553.1}, B6I68_21040
GN {ECO:0000313|EMBL:PLE25740.1}, BANRA_04618
GN {ECO:0000313|EMBL:VCX99946.1}, BB784_24605
GN {ECO:0000313|EMBL:APP54915.1}, BL124_00000640
GN {ECO:0000313|EMBL:ROH05643.1}, CK244_007915
GN {ECO:0000313|EMBL:QBH42908.1}, DL426_03730
GN {ECO:0000313|EMBL:QDX69659.1}, EAO17_16650
GN {ECO:0000313|EMBL:RRF07721.1}, FXN67_11755
GN {ECO:0000313|EMBL:TYL79314.1}, G4V31_03910
GN {ECO:0000313|EMBL:NGN71272.1}, G7Z27_24370
GN {ECO:0000313|EMBL:QLI10707.1}, GJJ08_024055
GN {ECO:0000313|EMBL:QOU51353.1}, GJJ13_022590
GN {ECO:0000313|EMBL:QOU78271.1}, GJJ18_15420
GN {ECO:0000313|EMBL:MRL36815.1}, GNF00_10835
GN {ECO:0000313|EMBL:MUA40344.1}, HJX03_24230
GN {ECO:0000313|EMBL:QJL31432.1}, NCTC13443_01260
GN {ECO:0000313|EMBL:STT00960.1}, NCTC13465_04872
GN {ECO:0000313|EMBL:SQC48666.1}, NCTC8849_00647
GN {ECO:0000313|EMBL:STT52126.1}, NCTC9128_05864
GN {ECO:0000313|EMBL:SQC39719.1}, NCTC9601_05449
GN {ECO:0000313|EMBL:SQC18565.1}, NCTC9661_05564
GN {ECO:0000313|EMBL:STU32866.1}, QIG75_25140
GN {ECO:0000313|EMBL:MDH8291831.1}, SAMEA3499874_03480
GN {ECO:0000313|EMBL:SXG17345.1}, SAMEA3499901_01585
GN {ECO:0000313|EMBL:SXN30579.1}, SAMEA3512100_04243
GN {ECO:0000313|EMBL:SXU35455.1}, SAMEA3515122_03762
GN {ECO:0000313|EMBL:SYH34418.1}, SAMEA3538658_03337
GN {ECO:0000313|EMBL:SYK82426.1}, SAMEA3538828_03333
GN {ECO:0000313|EMBL:SYR42425.1}, SAMEA3720909_03817
GN {ECO:0000313|EMBL:SWF74798.1}, SAMEA4364603_03283
GN {ECO:0000313|EMBL:SSK42515.1}, SAMEA4370542_03471
GN {ECO:0000313|EMBL:SLS63537.1}, SAMEA4873597_03983
GN {ECO:0000313|EMBL:VGJ40337.1}, SAMEA4873632_04454
GN {ECO:0000313|EMBL:VGL09995.1};
OS Klebsiella pneumoniae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=573 {ECO:0000313|EMBL:MUA40344.1, ECO:0000313|Proteomes:UP000485085};
RN [1] {ECO:0000313|EMBL:APP54915.1, ECO:0000313|Proteomes:UP000184679}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Kp_Goe_827024 {ECO:0000313|EMBL:APP54915.1,
RC ECO:0000313|Proteomes:UP000184679};
RA Bohne W., Bunk B., Overmann J., Gross U., Zautner A.E.;
RT "A nosocomial outbreak of oxa48-expressing Klebsialla pneumoniae in Lower
RT Saxony.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PLE25740.1, ECO:0000313|Proteomes:UP000234439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COL-Kpn30 {ECO:0000313|EMBL:PLE25740.1,
RC ECO:0000313|Proteomes:UP000234439};
RX PubMed=29029188; DOI=.1093/infdis/jix524;
RA Rojas L.J., Weinstock G.M., De La Cadena E., Diaz L., Rios R., Hanson B.M.,
RA Brown J.S., Vats P., Phillips D.S., Nguyen H., Hujer K.M., Correa A.,
RA Adams M.D., Perez F., Sodergren E., Narechania A., Planet P.J.,
RA Villegas M.V., Bonomo R.A., Arias C.A.;
RT "An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase-
RT Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates
RT the "Perfect Storm".";
RL J. Infect. Dis. 217:82-92(2017).
RN [3] {ECO:0000313|EMBL:OVF62553.1, ECO:0000313|Proteomes:UP000196447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=39383 {ECO:0000313|EMBL:OVF62553.1,
RC ECO:0000313|Proteomes:UP000196447};
RA Fouts D., Stalin M.J., Chen L., Wright M., Sutton G., Nguyen K.,
RA Vanduin D., Rojas L., Hujer A., Hujer K., Bonomo R., Kreiswirth B.,
RA Adams M.;
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:RRF07721.1, ECO:0000313|Proteomes:UP000275975}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF07721.1,
RC ECO:0000313|Proteomes:UP000275975};
RX PubMed=30373801;
RA Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S.,
RA Carroll K.C., Schatz M.C., Timp W., Simner P.J.;
RT "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial
RT Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella
RT pneumoniae Clinical Isolates.";
RL Antimicrob. Agents Chemother. 0:0-0(2018).
RN [5] {ECO:0000313|EMBL:QDX69659.1, ECO:0000313|Proteomes:UP000320592}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DA12090 {ECO:0000313|EMBL:QDX69659.1,
RC ECO:0000313|Proteomes:UP000320592};
RA Sandegren L.;
RT "Genome sequence of Klebsiella pneumoniae DA12090 (CAS55).";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|Proteomes:UP000251088, ECO:0000313|Proteomes:UP000251123}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC13443 {ECO:0000313|EMBL:STT00960.1,
RC ECO:0000313|Proteomes:UP000255518}, NCTC13465
RC {ECO:0000313|EMBL:SQC48666.1, ECO:0000313|Proteomes:UP000251721},
RC NCTC8849 {ECO:0000313|EMBL:STT52126.1,
RC ECO:0000313|Proteomes:UP000254799}, NCTC9128
RC {ECO:0000313|EMBL:SQC39719.1, ECO:0000313|Proteomes:UP000251088},
RC NCTC9601 {ECO:0000313|EMBL:SQC18565.1,
RC ECO:0000313|Proteomes:UP000251123}, and NCTC9661
RC {ECO:0000313|EMBL:STU32866.1, ECO:0000313|Proteomes:UP000255137};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|Proteomes:UP000257587, ECO:0000313|Proteomes:UP000258253}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK42515.1,
RC ECO:0000313|Proteomes:UP000252603}, 5012STDY7626396
RC {ECO:0000313|EMBL:VGJ40337.1, ECO:0000313|Proteomes:UP000295133},
RC 5012STDY7626430 {ECO:0000313|EMBL:VGL09995.1,
RC ECO:0000313|Proteomes:UP000376235}, EuSCAPE_AT002
RC {ECO:0000313|EMBL:SXG17345.1, ECO:0000313|Proteomes:UP000257587},
RC EuSCAPE_AT029 {ECO:0000313|EMBL:SXN30579.1,
RC ECO:0000313|Proteomes:UP000259975}, EuSCAPE_DE072
RC {ECO:0000313|EMBL:SXU35455.1, ECO:0000313|Proteomes:UP000259753},
RC EuSCAPE_HU047 {ECO:0000313|EMBL:SYR42425.1,
RC ECO:0000313|Proteomes:UP000258253}, EuSCAPE_IT093
RC {ECO:0000313|EMBL:SYH34418.1, ECO:0000313|Proteomes:UP000258673},
RC EuSCAPE_IT290 {ECO:0000313|EMBL:SYK82426.1,
RC ECO:0000313|Proteomes:UP000258808}, EuSCAPE_UK014
RC {ECO:0000313|EMBL:SWF74798.1, ECO:0000313|Proteomes:UP000259364}, and
RC VRES1272 {ECO:0000313|EMBL:SLS63537.1,
RC ECO:0000313|Proteomes:UP000191996};
RG Pathogen Informatics;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:ROH05643.1, ECO:0000313|Proteomes:UP000283322}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CRK0165 {ECO:0000313|EMBL:ROH05643.1,
RC ECO:0000313|Proteomes:UP000283322};
RA Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B.,
RA Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:VCX99946.1, ECO:0000313|Proteomes:UP000278966}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Kpneu025 {ECO:0000313|EMBL:VCX99946.1};
RA Noll B N.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:QBH42908.1, ECO:0000313|Proteomes:UP000218354}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VBA2172 {ECO:0000313|EMBL:QBH42908.1,
RC ECO:0000313|Proteomes:UP000218354};
RA Veeraraghavan B., Shankar C., Vasudevan K., Venkatesan M., Narasimman V.;
RT "VBA2172 Klebsiella pneumoniae hybrid assembly.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:TYL79314.1, ECO:0000313|Proteomes:UP000322977}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCO-494 {ECO:0000313|EMBL:TYL79314.1,
RC ECO:0000313|Proteomes:UP000322977};
RA Morales-Leon F., Caro C., Opazo-Capurro A., Lincopan N.,
RA Dominguez-Yevenes M., Lima C., Bello-Toledo H., Gonzalez-Rocha G.;
RT "Phenotypic and genetic characterization of extended-spectrum b-lactamase-
RT producing hypermucoviscous Klebsiella pneumoniae from Chile.";
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:MRL36815.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CriePir115 {ECO:0000313|EMBL:MRL36815.1};
RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA Fomina V., Gusarov V., Zamyatin M., Shagin D.;
RT "Molecular typing, antibiotic resistance determination and virulence
RT profiling for 36 multidrug-resistant clinical Klebsiella pneumoniae
RT isolates using second- and third-generation sequencing.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|EMBL:MUA40344.1, ECO:0000313|Proteomes:UP000485085}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KP_38044 {ECO:0000313|EMBL:MUA40344.1,
RC ECO:0000313|Proteomes:UP000485085};
RA Zhou K.;
RT "Emergence of a novel subclone of carbapenem-resistant Klebsiella
RT pneumoniae ST11 with enhanced virulence and transmissibility: a molecular
RT epidemiological, clinical, genomic study.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|Proteomes:UP000438340, ECO:0000313|Proteomes:UP000439817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CriePir120 {ECO:0000313|EMBL:QOU51353.1,
RC ECO:0000313|Proteomes:UP000439817}, and CriePir45
RC {ECO:0000313|EMBL:QOU78271.1, ECO:0000313|Proteomes:UP000438340};
RX PubMed=32429555;
RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.;
RT "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence
RT Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella
RT pneumoniae Isolates.";
RL Antibiotics 9:E261-E261(2020).
RN [15] {ECO:0000313|EMBL:NGN71272.1, ECO:0000313|Proteomes:UP000479475}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2429 {ECO:0000313|EMBL:NGN71272.1,
RC ECO:0000313|Proteomes:UP000479475};
RA Starkova P.S., Sulyan O.S., Likholetova D.V., Ageevets V.A., Lazareva I.V.,
RA Sopova J.V., Sidorenko S.V.;
RT "Klebsiella pneumoniae genome sequencing and assembly.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [16] {ECO:0000313|EMBL:QLI10707.1, ECO:0000313|Proteomes:UP000509467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=11KM256 {ECO:0000313|EMBL:QLI10707.1,
RC ECO:0000313|Proteomes:UP000509467};
RA Brilhante M., Perreten V.;
RT "Whole genome sequencing of global problem clones of OXA-48-producing
RT Klebsiella pneumoniae from the veterinary setting in Switzerland.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [17] {ECO:0000313|EMBL:QJL31432.1, ECO:0000313|Proteomes:UP000503203}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C16KP0122 {ECO:0000313|EMBL:QJL31432.1,
RC ECO:0000313|Proteomes:UP000503203};
RA Yoon E.-J., Gwon B., Liu C., Kim D., Won D., Park S.G., Choi J.R.,
RA Jeong S.H.;
RT "Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella
RT pneumoniae ensuring stable propagation of the multidrug-resistant pathogen
RT in clinical settings.";
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
RN [18] {ECO:0000313|EMBL:MDH8291831.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sgh23 {ECO:0000313|EMBL:MDH8291831.1};
RA Chen Y., Gan Y.-H.;
RT "WGS of Klebsiella strains from the Antibiotics for Klebsiella Liver
RT Abscess Syndrome Study (A-KLASS) clinical trial, Singapore.";
RL Submitted (APR-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the condensation of carbamoyl phosphate and
CC aspartate to form carbamoyl aspartate and inorganic phosphate, the
CC committed step in the de novo pyrimidine nucleotide biosynthesis
CC pathway. {ECO:0000256|HAMAP-Rule:MF_00001}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-
CC aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:58228; EC=2.1.3.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001363, ECO:0000256|HAMAP-
CC Rule:MF_00001};
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC (S)-dihydroorotate from bicarbonate: step 2/3.
CC {ECO:0000256|ARBA:ARBA00004852, ECO:0000256|HAMAP-Rule:MF_00001}.
CC -!- SUBUNIT: Heterododecamer (2C3:3R2) of six catalytic PyrB chains
CC organized as two trimers (C3), and six regulatory PyrI chains organized
CC as three dimers (R2). {ECO:0000256|HAMAP-Rule:MF_00001}.
CC -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC superfamily. ATCase family. {ECO:0000256|ARBA:ARBA00008896,
CC ECO:0000256|HAMAP-Rule:MF_00001}.
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DR EMBL; CP018701; APP54915.1; -; Genomic_DNA.
DR EMBL; JARYWG010000034; MDH8291831.1; -; Genomic_DNA.
DR EMBL; WJWF01000013; MRL36815.1; -; Genomic_DNA.
DR EMBL; WNPO01000015; MUA40344.1; -; Genomic_DNA.
DR EMBL; JAAKYD010000003; NGN71272.1; -; Genomic_DNA.
DR EMBL; NDBK01000131; OVF62553.1; -; Genomic_DNA.
DR EMBL; NCMJ01000116; PLE25740.1; -; Genomic_DNA.
DR EMBL; CP036320; QBH42908.1; -; Genomic_DNA.
DR EMBL; CP030072; QDX69659.1; -; Genomic_DNA.
DR EMBL; CP052431; QJL31432.1; -; Genomic_DNA.
DR EMBL; CP049716; QLI10707.1; -; Genomic_DNA.
DR EMBL; CP063008; QOU51353.1; -; Genomic_DNA.
DR EMBL; CP063023; QOU78271.1; -; Genomic_DNA.
DR EMBL; MPYG04000004; ROH05643.1; -; Genomic_DNA.
DR EMBL; RDAM01000001; RRF07721.1; -; Genomic_DNA.
DR EMBL; FWJM01000011; SLS63537.1; -; Genomic_DNA.
DR EMBL; UASN01000022; SQC18565.1; -; Genomic_DNA.
DR EMBL; UAWN01000014; SQC39719.1; -; Genomic_DNA.
DR EMBL; UAWQ01000019; SQC48666.1; -; Genomic_DNA.
DR EMBL; UFEU01000008; SSK42515.1; -; Genomic_DNA.
DR EMBL; UGKT01000001; STT00960.1; -; Genomic_DNA.
DR EMBL; UGLC01000002; STT52126.1; -; Genomic_DNA.
DR EMBL; UGLQ01000003; STU32866.1; -; Genomic_DNA.
DR EMBL; UJHH01000018; SWF74798.1; -; Genomic_DNA.
DR EMBL; UKAW01000009; SXG17345.1; -; Genomic_DNA.
DR EMBL; UKGE01000005; SXN30579.1; -; Genomic_DNA.
DR EMBL; UKLK01000009; SXU35455.1; -; Genomic_DNA.
DR EMBL; UKUT01000008; SYH34418.1; -; Genomic_DNA.
DR EMBL; UKXO01000012; SYK82426.1; -; Genomic_DNA.
DR EMBL; ULCI01000013; SYR42425.1; -; Genomic_DNA.
DR EMBL; VSSY01000008; TYL79314.1; -; Genomic_DNA.
DR EMBL; UWWS01000001; VCX99946.1; -; Genomic_DNA.
DR EMBL; CAAHAW010000011; VGJ40337.1; -; Genomic_DNA.
DR EMBL; CAAHCC010000010; VGL09995.1; -; Genomic_DNA.
DR RefSeq; WP_002886928.1; NZ_WYAM01000019.1.
DR GeneID; 69757446; -.
DR KEGG; kpne:KU54_024010; -.
DR KEGG; kpnk:BN49_4780; -.
DR KEGG; kpnu:LI86_23850; -.
DR KEGG; kpx:PMK1_02125; -.
DR OMA; DRIQPPG; -.
DR UniPathway; UPA00070; UER00116.
DR Proteomes; UP000184679; Chromosome.
DR Proteomes; UP000191996; Unassembled WGS sequence.
DR Proteomes; UP000196447; Unassembled WGS sequence.
DR Proteomes; UP000218354; Chromosome.
DR Proteomes; UP000234439; Unassembled WGS sequence.
DR Proteomes; UP000251088; Unassembled WGS sequence.
DR Proteomes; UP000251123; Unassembled WGS sequence.
DR Proteomes; UP000251721; Unassembled WGS sequence.
DR Proteomes; UP000252603; Unassembled WGS sequence.
DR Proteomes; UP000254799; Unassembled WGS sequence.
DR Proteomes; UP000255137; Unassembled WGS sequence.
DR Proteomes; UP000255518; Unassembled WGS sequence.
DR Proteomes; UP000257587; Unassembled WGS sequence.
DR Proteomes; UP000258253; Unassembled WGS sequence.
DR Proteomes; UP000258673; Unassembled WGS sequence.
DR Proteomes; UP000258808; Unassembled WGS sequence.
DR Proteomes; UP000259364; Unassembled WGS sequence.
DR Proteomes; UP000259753; Unassembled WGS sequence.
DR Proteomes; UP000259975; Unassembled WGS sequence.
DR Proteomes; UP000275975; Unassembled WGS sequence.
DR Proteomes; UP000278966; Unassembled WGS sequence.
DR Proteomes; UP000283322; Unassembled WGS sequence.
DR Proteomes; UP000295133; Unassembled WGS sequence.
DR Proteomes; UP000320592; Chromosome.
DR Proteomes; UP000322977; Unassembled WGS sequence.
DR Proteomes; UP000376235; Unassembled WGS sequence.
DR Proteomes; UP000438340; Chromosome.
DR Proteomes; UP000439817; Chromosome.
DR Proteomes; UP000479475; Unassembled WGS sequence.
DR Proteomes; UP000485085; Unassembled WGS sequence.
DR Proteomes; UP000503203; Chromosome.
DR Proteomes; UP000509467; Chromosome.
DR Proteomes; UP001157099; Unassembled WGS sequence.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1370; Aspartate/ornithine carbamoyltransferase; 2.
DR HAMAP; MF_00001; Asp_carb_tr; 1.
DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf.
DR InterPro; IPR002082; Asp_carbamoyltransf.
DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR NCBIfam; TIGR00670; asp_carb_tr; 1.
DR PANTHER; PTHR45753:SF6; ASPARTATE CARBAMOYLTRANSFERASE; 1.
DR PANTHER; PTHR45753; ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF00185; OTCace; 1.
DR Pfam; PF02729; OTCace_N; 1.
DR PRINTS; PR00100; AOTCASE.
DR PRINTS; PR00101; ATCASE.
DR SUPFAM; SSF53671; Aspartate/ornithine carbamoyltransferase; 1.
DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE 3: Inferred from homology;
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975, ECO:0000256|HAMAP-
KW Rule:MF_00001};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00001}.
FT DOMAIN 8..148
FT /note="Aspartate/ornithine carbamoyltransferase carbamoyl-P
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02729"
FT DOMAIN 155..303
FT /note="Aspartate/ornithine carbamoyltransferase Asp/Orn-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF00185"
FT BINDING 55
FT /ligand="carbamoyl phosphate"
FT /ligand_id="ChEBI:CHEBI:58228"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00001"
FT BINDING 56
FT /ligand="carbamoyl phosphate"
FT /ligand_id="ChEBI:CHEBI:58228"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00001"
FT BINDING 85
FT /ligand="L-aspartate"
FT /ligand_id="ChEBI:CHEBI:29991"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00001"
FT BINDING 106
FT /ligand="carbamoyl phosphate"
FT /ligand_id="ChEBI:CHEBI:58228"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00001"
FT BINDING 135
FT /ligand="carbamoyl phosphate"
FT /ligand_id="ChEBI:CHEBI:58228"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00001"
FT BINDING 138
FT /ligand="carbamoyl phosphate"
FT /ligand_id="ChEBI:CHEBI:58228"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00001"
FT BINDING 168
FT /ligand="L-aspartate"
FT /ligand_id="ChEBI:CHEBI:29991"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00001"
FT BINDING 230
FT /ligand="L-aspartate"
FT /ligand_id="ChEBI:CHEBI:29991"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00001"
FT BINDING 268
FT /ligand="carbamoyl phosphate"
FT /ligand_id="ChEBI:CHEBI:58228"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00001"
FT BINDING 269
FT /ligand="carbamoyl phosphate"
FT /ligand_id="ChEBI:CHEBI:58228"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00001"
SQ SEQUENCE 311 AA; 34237 MW; E4F2C3CB6D063432 CRC64;
MANPLYQKHI ISINDLSRED LELVLATAAK LKANPQPELL KHKVIASCFF EASTRTRLSF
ETSMHRLGAS VVGFSDSANT SLGKKGETLA DTISVISTYV DAIVMRHPQE GAARLATEFS
GGVPVLNAGD GANQHPTQTL LDLFTIQETQ GRLENLNVAM VGDLKYGRTV HSLTQALAKF
NGNRFYFIAP DALAMPQYIL DMLDEKGIAW SLHSAIDDVM AEVDILYMTR VQKERLDPSE
YANVKAQFVL RAADLEGARA NMKVLHPLPR IDEITTDVDK TPHAWYFQQA GNGIFARQAL
LALVLNSELA L
//
