ID W9DT89_METTI Unreviewed; 1445 AA.
AC W9DT89;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Subtilisin-like serine protease {ECO:0000313|EMBL:ETA69018.1};
GN ORFNames=MettiDRAFT_2508 {ECO:0000313|EMBL:ETA69018.1};
OS Methanolobus tindarius DSM 2278.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanolobus.
OX NCBI_TaxID=1090322 {ECO:0000313|EMBL:ETA69018.1, ECO:0000313|Proteomes:UP000019483};
RN [1] {ECO:0000313|EMBL:ETA69018.1, ECO:0000313|Proteomes:UP000019483}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2278 {ECO:0000313|EMBL:ETA69018.1,
RC ECO:0000313|Proteomes:UP000019483};
RG DOE Joint Genome Institute;
RA Eisen J., Huntemann M., Han J., Chen A., Kyrpides N., Mavromatis K.,
RA Markowitz V., Palaniappan K., Ivanova N., Schaumberg A., Pati A.,
RA Liolios K., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETA69018.1}.
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DR EMBL; AZAJ01000001; ETA69018.1; -; Genomic_DNA.
DR RefSeq; WP_023846152.1; NZ_AZAJ01000001.1.
DR STRING; 1090322.MettiDRAFT_2508; -.
DR OrthoDB; 341609at2157; -.
DR Proteomes; UP000019483; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04842; Peptidases_S8_Kp43_protease; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR026453; PGF_pre_PGF.
DR InterPro; IPR034058; TagA/B/C/D_pept_dom.
DR NCBIfam; TIGR04213; PGF_pre_PGF; 1.
DR PANTHER; PTHR43399:SF5; CELL WALL-ASSOCIATED PROTEASE; 1.
DR PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1423..1440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 241..577
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT REGION 1197..1225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1392..1419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 250
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 288
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 511
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1445 AA; 156502 MW; 48D69F5B05A152E1 CRC64;
MRSKNTILTS LVLILLITSF SASAGTNNSY LTNSDTLFLK AGHVNTTYTD EDNYAFLSLN
SVSSENTYAY YIVQFSGPVR DQWKQDIIST GAELYTYVPN NAFVVRMNAS SMAQVNELAF
VKWIGEYKST YKYDPEIESD SSLEQGLYSA ETEENKTYYI SLFSADEYLN VLESLESLGV
EVLGGYGKTI RVKASDSQID SIVVISGISW IEEYVQPTFD NNIATGIITT DVVHDTYGLN
GSGQVVAVAD TGIDVGVDNE SMHADLRGRI LAIFDIAEDG AADVASGHGT HVSGSVLGNG
SLSGGQYAGM APEAKLVMQA LGSTSDGLYL PSGGLEELFQ MAYNESARIH TNSWGSDTKG
LYTEYSEAVD QFMWDHQDML ILFSAGNEGI DSDSDGVIDP DSIGSPATAK NCLTVGASEN
ERGATFSVPP YTKWGLAWPN FYPASPISDD YMASDSDGIA AFSSRGPTDD GRIKPDVVAP
GTFIASTRSS VATGTGWGLI NSNYLYMGGT SMSTPITAGS AALVREYYTE VENLSSPSAS
LLKATLINGA CNITPGQYGT GDYQEVSGRP DYSQGWGRVD IENSIYPQSP VVMRYYDYIP
LNYSESWNVS YDILHTSRPV RVTLVWTDYP GDSLVEMQLV NNLDLIVEAP DGTYYGNGAP
DTVNNVEGIE LLEPVAGTYT IIVNGTNVPQ GPQNFSLVIS YGELSNIYMY PEHNSYTTNA
STDVYMNLTH VDGINSSSIE MQIDGSSVSY SLEAISAGYK VQNQSQSYSE GFHNVSVTAL
TDQNEELNYG WRFYVSIEDN ILTVQSPLEN SVIQDNTVQI NASNNKWCDF WYRIDNGTNS
TSQSGYSLNA STVLSENTHN ITVYAEDITG FVNLTTVNFT VFTESAEIDS PASGSIYYLP
DDSFTLNGTV GVASNVSVYV NGALTNNSEP VSNGMFNVSN VPLLNGTNTV NVSAIYNNSQ
NEYFVSNTTI YLSLGQTTDT SSGDQITVTV PGIDTNVSNP VFNFNISGTS ANPGNISASA
IRGNQPGNGS YLTGTVLDIR VYNESDLNYS YQFGRNVSLT LGYDPYRVNN TAKLTVGWYD
PDEGIWIPYR SIANTTAHTV TTNITHLSIY APLEDNTAPV ISSVSNSSTS SSITLDWNSS
DDTDHVEVWR SGSLLGNYSG SEMTDTGLSA STLYNYSLRA VDYVENTGEW YNTSVRTSAA
TSTSSTSTSS GGGGGGGGGG GGSTGEDVDN IEFKDVLSVY AGKDDLVDYD FTKEQNEIDY
VRYTSLKNAG KISVTIEILK NTSALVNTAA SGLVYKNMNI WVGKTGYATE SNIKDPVIGF
MVSKDWVDDN DVNIGTIALN RYSDDVWSRL ETEQTGEDAD YYYFEASTPG FSPFAVTADI
PVISAEEQET INHQTEAASP DDDEEGEPVF YEENNTEDKD TPAFSTTLTL LILTFAFVFI
RKQQN
//
