ID W9DXD9_METTI Unreviewed; 297 AA.
AC W9DXD9;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Formylmethanofuran--tetrahydromethanopterin formyltransferase {ECO:0000256|HAMAP-Rule:MF_00579};
DE Short=Ftr {ECO:0000256|HAMAP-Rule:MF_00579};
DE EC=2.3.1.101 {ECO:0000256|HAMAP-Rule:MF_00579};
DE AltName: Full=H4MPT formyltransferase {ECO:0000256|HAMAP-Rule:MF_00579};
GN Name=ftr {ECO:0000256|HAMAP-Rule:MF_00579};
GN ORFNames=MettiDRAFT_1498 {ECO:0000313|EMBL:ETA68051.1};
OS Methanolobus tindarius DSM 2278.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanolobus.
OX NCBI_TaxID=1090322 {ECO:0000313|EMBL:ETA68051.1, ECO:0000313|Proteomes:UP000019483};
RN [1] {ECO:0000313|EMBL:ETA68051.1, ECO:0000313|Proteomes:UP000019483}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2278 {ECO:0000313|EMBL:ETA68051.1,
RC ECO:0000313|Proteomes:UP000019483};
RG DOE Joint Genome Institute;
RA Eisen J., Huntemann M., Han J., Chen A., Kyrpides N., Mavromatis K.,
RA Markowitz V., Palaniappan K., Ivanova N., Schaumberg A., Pati A.,
RA Liolios K., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reversible transfer of a formyl group from
CC formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to
CC produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and
CC methanofuran (MFR). {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran
CC = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin;
CC Xref=Rhea:RHEA:18061, ChEBI:CHEBI:15378, ChEBI:CHEBI:57727,
CC ChEBI:CHEBI:58018, ChEBI:CHEBI:58103, ChEBI:CHEBI:58151;
CC EC=2.3.1.101; Evidence={ECO:0000256|HAMAP-Rule:MF_00579};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3.
CC {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- SIMILARITY: Belongs to the FTR family. {ECO:0000256|ARBA:ARBA00006770,
CC ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETA68051.1}.
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DR EMBL; AZAJ01000001; ETA68051.1; -; Genomic_DNA.
DR RefSeq; WP_023845187.1; NZ_AZAJ01000001.1.
DR AlphaFoldDB; W9DXD9; -.
DR STRING; 1090322.MettiDRAFT_1498; -.
DR OrthoDB; 81373at2157; -.
DR UniPathway; UPA00640; UER00693.
DR Proteomes; UP000019483; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030270; F:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.520; -; 2.
DR HAMAP; MF_00579; FTR; 1.
DR InterPro; IPR014053; ForMFR_H4MPT_ForTrfase.
DR InterPro; IPR002770; ForMFR_H4MPT_ForTrfase_C.
DR InterPro; IPR023447; ForMFR_H4MPT_ForTrfase_fd-like.
DR InterPro; IPR022667; ForMFR_H4MPT_ForTrfase_N.
DR NCBIfam; TIGR03119; one_C_fhcD; 1.
DR Pfam; PF01913; FTR; 1.
DR Pfam; PF02741; FTR_C; 1.
DR PIRSF; PIRSF006414; Ftr_formyl_trnsf; 1.
DR SUPFAM; SSF55112; Formylmethanofuran:tetrahydromethanopterin formyltransferase; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|HAMAP-Rule:MF_00579,
KW ECO:0000313|EMBL:ETA68051.1}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00579};
KW Methanogenesis {ECO:0000256|HAMAP-Rule:MF_00579};
KW One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_00579};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00579}.
FT DOMAIN 1..144
FT /note="Formylmethanofuran: tetrahydromethanopterin
FT formyltransferase Ftr N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01913"
FT DOMAIN 147..296
FT /note="Formylmethanofuran: tetrahydromethanopterin
FT formyltransferase Ftr C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02741"
SQ SEQUENCE 297 AA; 31739 MW; B7AB92373E2D2CFA CRC64;
MEINGVEIED TFAEAFPIKI SRVLITAATK RWAEIAALEA TGFGTSVIMC PAEAGIEKFV
GPDETPDGRP GVYIQICTFG YESLEHQLLE RLGQCVLTAP TTAVFNGMPE AEKQFNVGFK
LKFFGDGMES ETEVDGRKMY SIPIMEGDFL VEENIGAVAG IAGGNFFIFG DSQMTALTAA
EVAVDAIKDL EGTITPFPGG IVASGSKAGF NNYKFMKATA NEKFCPSIRD KVEGTEIPEG
VKAVYELVIN GVDEDAIQKA MKAGIEAAIA VPGVSKITAG NYGGKLGKYQ FHLKDLC
//
