ID W9ELT4_9LACO Unreviewed; 777 AA.
AC W9ELT4;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=B808_443 {ECO:0000313|EMBL:ETO40644.1};
OS Fructilactobacillus florum 8D.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Fructilactobacillus.
OX NCBI_TaxID=1221538 {ECO:0000313|EMBL:ETO40644.1, ECO:0000313|Proteomes:UP000019474};
RN [1] {ECO:0000313|EMBL:ETO40644.1, ECO:0000313|Proteomes:UP000019474}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=8D {ECO:0000313|EMBL:ETO40644.1,
RC ECO:0000313|Proteomes:UP000019474};
RA Kim E.B., Marco M.L.;
RT "Genome sequencing of Lactobacillus florum 8D.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETO40644.1}.
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DR EMBL; ALXG01000017; ETO40644.1; -; Genomic_DNA.
DR RefSeq; WP_035421645.1; NZ_ALXG01000017.1.
DR AlphaFoldDB; W9ELT4; -.
DR PATRIC; fig|1221538.3.peg.447; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000019474; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF29; PENICILLIN-BINDING PROTEIN 1A; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000019474};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..248
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 345..593
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 668..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 86913 MW; 864F008308B5CDC4 CRC64;
MSSDETYSRL QKNKRKARPF LHIFLWIVFF VFLLFLMGVG LFTYYAASAP HVSYHTLSSD
NSTTIYDRNG QVISRLGMQN RDYVKHQDIP ENLKNAIISV EDRHFYQDKG VDPIRIVEAG
VSNIFGRSGG LQGGSTLTQQ LIKLSVFSTK ASDQTLKRKA QEAWLAVKVD KDYSKQQILE
FYINKVYMGN NSYGMQTISQ TLYHKPLNQL DLAQTALLAG LPQAPVAYNP VTNPKYATIR
RNQVLDAMVK NKAISQKQAN QAKRQNVQNG IDKANVNKTP TQKDEKYADA YISQVTQEMR
AKGFNLNAGN KIYTNLDMNT QKHMYQLAND DNAGLAFNNN DFQIGATMVN PQNGKVVSML
GSRKQNVLFG LNRAVQTDHS SGSTMKPLMD YGPAIEYLKY PTYQSMKDTP FTYPGTDKQL
NDFDNKHQGT ITMRQALVQS RNIPAIRTLQ DVGIPRATEF LKGLGMTFKE PLNLQNGIGA
YISSEQEAAA YAAFANGGTY HEPYLINKIV TPTGESKQFK AKSHRAMSPA TAFMITDMLK
GVMTDPQGSG TAANIAGLYQ AGKTGTTQYP DNYLNQVPKN ASMDSWFTGY TKNLSLSIWT
GFDRPLEPDH YLSEPQTKIA QQFYKQVMER ASENQPNENW TKPDDVVKTK KNGQTQYYIV
GHGADQTQRV NTTASQSQQA ADNQSVVPNQ ADNKQQDQTT NEPTNGMATP TEQTPTPINN
DQPQNTPTPS ENQPSQPTQN NNQQPQTNQQ PDQQNQPSQP AQPQTDSNQQ QQQQPNQ
//
