ID W9H591_9PROT Unreviewed; 781 AA.
AC W9H591;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:EWY41405.1};
GN ORFNames=N825_28205 {ECO:0000313|EMBL:EWY41405.1};
OS Skermanella stibiiresistens SB22.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Azospirillaceae; Skermanella.
OX NCBI_TaxID=1385369 {ECO:0000313|EMBL:EWY41405.1, ECO:0000313|Proteomes:UP000019486};
RN [1] {ECO:0000313|EMBL:EWY41405.1, ECO:0000313|Proteomes:UP000019486}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB22 {ECO:0000313|EMBL:EWY41405.1,
RC ECO:0000313|Proteomes:UP000019486};
RA Zhu W., Wang G.;
RT "The genome sequence of Skermanella stibiiresistens.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWY41405.1}.
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DR EMBL; AVFL01000004; EWY41405.1; -; Genomic_DNA.
DR RefSeq; WP_037449246.1; NZ_AVFL01000004.1.
DR AlphaFoldDB; W9H591; -.
DR STRING; 1385369.N825_28205; -.
DR PATRIC; fig|1385369.3.peg.1580; -.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000019486; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000019486}.
FT DOMAIN 6..193
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 196..297
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 348..406
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 781 AA; 83662 MW; 282A1F21848E3E10 CRC64;
MEIRSAAVIG AGVMGSGIAA HIANAGIPVF LLDIVPPEVI EGRGNDRSVV ARAAIERMLK
TEPAAFTHKR NARLVTPGNI DDDLEKLAGV DWIVEAVVEN PAVKSALYSR LDAVRKPGSI
VSSNTSTIPL KNLIEGQSAR FAEDFMITHF FNPPRYMRLL EVVAGPDTRP DAVAGLSRFA
DTRLGKGVVA CKDRPGFIAN RIGTYWIQAA INEAMDLGLT IEEADAVVGR PMGIPKTGVF
GLVDLVGLDL MPYVSRSLLK TLPPDDPYRS IHREPELFTR MIAEGYTGRK GKGGFYRMNK
SGGARVKEAI DLSTGQYRAS EKATLESVGA AKQGLRALVE HPDKGGTYAR RVLTGVLGYA
ASLVPEIADD ITAVDQAMRL GYNWKYGPFE LIDQLGPDWL ADALRAEGKP VPALLERAAG
QGFYLTEGGK RRFLTVAGDY ADIVRPDGVL LLSDIKLGSK PIKRNGSAAL WDIGDGVVCL
EFTGKMNALD GDVMALIQTA IGMIGDGENE WKALVVHNEG DNFSVGVNLG LALFAINIAM
WPQVEQSVQE GQETYKALKY APFPVVAAPS GMALGGGCEI LLHCDAVQAH VETYMGLVEV
GVGVIPGWGG CKEMLTRATL NKKRPGGPMP PIAQVFETIS LAKVAKSAEE ARDLMFLRPT
DGITINRDRL LADAKAKALE LAKDYAPPEP VALRLPGPTA RAALDLAVDG FRLQGKATPH
DVVVSSALAG VLSGGDTDIT VEIDEDGLLE LERTAFLKLV RSRATIARIE HMLGTGKPLR
N
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