ID W9NFD6_FUSOX Unreviewed; 823 AA.
AC W9NFD6;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Phenol 2-monooxygenase {ECO:0000313|EMBL:EXA28692.1};
GN ORFNames=FOVG_19719 {ECO:0000313|EMBL:EXA28692.1};
OS Fusarium oxysporum f. sp. pisi HDV247.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=1080344 {ECO:0000313|EMBL:EXA28692.1};
RN [1] {ECO:0000313|EMBL:EXA28692.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HDV247 {ECO:0000313|EMBL:EXA28692.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Gale L.R., Schwartz D.C., Zhou S., Corby-Kistler H., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusarium oxysporum HDV247.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EXA28692.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HDV247 {ECO:0000313|EMBL:EXA28692.1};
RG The Broad Institute Genomics Platform;
RA Ma L.-J., Corby-Kistler H., Broz K., Gale L.R., Jonkers W., O'Donnell K.,
RA Ploetz R., Steinberg C., Schwartz D.C., VanEtten H., Zhou S., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "Annotation of the Genome Sequence of Fusarium oxysporum HDV247.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PheA/TfdB FAD monooxygenase family.
CC {ECO:0000256|ARBA:ARBA00007801}.
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DR EMBL; JH651196; EXA28692.1; -; Genomic_DNA.
DR AlphaFoldDB; W9NFD6; -.
DR HOGENOM; CLU_009665_9_2_1; -.
DR Proteomes; UP000030751; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR CDD; cd02979; PHOX_C; 1.
DR Gene3D; 3.40.30.20; -; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012941; Phe_hydrox_C_dim_dom.
DR InterPro; IPR038220; PHOX_C_sf.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR43004:SF20; 2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED; 1.
DR PANTHER; PTHR43004; TRK SYSTEM POTASSIUM UPTAKE PROTEIN; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR Pfam; PF07976; Phe_hydrox_dim; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Monooxygenase {ECO:0000313|EMBL:EXA28692.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 416..620
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
FT DOMAIN 657..822
FT /note="Phenol hydroxylase C-terminal dimerisation"
FT /evidence="ECO:0000259|Pfam:PF07976"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 93394 MW; 8E6FF3FA4166CA26 CRC64;
MTSPDSCFDI SDSGFGSAAE STPCPTPYPT RPTSTPVSTL RTSSASDEQY ERTLWRHFPG
WAFSERARET RCWAWQFGYD IQKEDARRWI CRACIRKNNP HPRHFEADGI HNAYNHLFND
HGIRAPPGMT QGTAEKKANS KGRKPPGQRT LAESMKLDLH DPREQAIAND FIKRFDKEHF
RRLLIDWIVA KNHSFSIAEE AELHAIFDYL NPLMLMTWLA RLGIKARIVD KRFDRINSGR
EDASRSTGKP HRLLDTRQAD GLQSRTFEIF DSLGFGQDVW REANHMLEIR FWSPGENKKL
YRSDRIVDTM PGLSRFQQAT LHQARIEDRL LKYIDKFSGI EVEYGVMPES LTIDADKVES
DDYPISVTLR SLPRPDADSP HVPADEGEPK IPNGLYRSNL TADSSDEILQ NAQTTKGTRT
EKVLAKYVVG CDGAHSWTRR QIRSVMEGDQ TDYIWGVLDI IPITDFPDIR YRCAIHSDSG
SMMVIPRESK YVRLYIQVTE ADENGKAIDR FKITPQTLVQ AANKILSPYK LSYKHCHWWT
AYRIGQRVGS KFNAHDRVFL AGDAVHTHSP KAGQGMNISM HDTFNLGWKL ASVVKGWAKR
SLLTTYTTER RQIAKELIEF DQRFSRLFSG RSAKDVLDEG GIDLKTFKQV FDKGNLFASG
CAVDYGASVI VAKPQAIENS NGTGAVATVG KQELAPNIPI GRRIPSCKVL NQSDARPWHL
QELMPSTGAW RVVVFAGDVL NSSQFSRLSA FGKALSSPSS FLNRHKPGED KRLASFFEIL
TVHSSPRHEV ELLSLPDIFH PYSEEYGWDY EKVFVDDVSY HQG
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