ID   W9VQJ9_9EURO            Unreviewed;       245 AA.
AC   W9VQJ9;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Orotate phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00014769};
DE            EC=2.4.2.10 {ECO:0000256|ARBA:ARBA00011971};
GN   ORFNames=A1O7_05415 {ECO:0000313|EMBL:EXJ57992.1};
OS   Cladophialophora yegresii CBS 114405.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC   Cladophialophora.
OX   NCBI_TaxID=1182544 {ECO:0000313|EMBL:EXJ57992.1, ECO:0000313|Proteomes:UP000019473};
RN   [1] {ECO:0000313|EMBL:EXJ57992.1, ECO:0000313|Proteomes:UP000019473}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 114405 {ECO:0000313|EMBL:EXJ57992.1,
RC   ECO:0000313|Proteomes:UP000019473};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Cladophialophora yegresii CBS 114405.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the transfer of a ribosyl phosphate group from 5-
CC       phosphoribose 1-diphosphate to orotate, leading to the formation of
CC       orotidine monophosphate (OMP). {ECO:0000256|ARBA:ARBA00003769}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-
CC         ribose 1-diphosphate + orotate; Xref=Rhea:RHEA:10380,
CC         ChEBI:CHEBI:30839, ChEBI:CHEBI:33019, ChEBI:CHEBI:57538,
CC         ChEBI:CHEBI:58017; EC=2.4.2.10;
CC         Evidence={ECO:0000256|ARBA:ARBA00001431};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       UMP from orotate: step 1/2. {ECO:0000256|ARBA:ARBA00004889}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. PyrE subfamily. {ECO:0000256|ARBA:ARBA00006340}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EXJ57992.1}.
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DR   EMBL; AMGW01000004; EXJ57992.1; -; Genomic_DNA.
DR   RefSeq; XP_007757615.1; XM_007759425.1.
DR   AlphaFoldDB; W9VQJ9; -.
DR   STRING; 1182544.W9VQJ9; -.
DR   GeneID; 19180000; -.
DR   VEuPathDB; FungiDB:A1O7_05415; -.
DR   eggNOG; KOG1377; Eukaryota.
DR   HOGENOM; CLU_074878_0_0_1; -.
DR   OrthoDB; 276022at2759; -.
DR   UniPathway; UPA00070; UER00119.
DR   Proteomes; UP000019473; Unassembled WGS sequence.
DR   GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   HAMAP; MF_01208; PyrE; 1.
DR   InterPro; IPR023031; OPRT.
DR   InterPro; IPR004467; Or_phspho_trans_dom.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   NCBIfam; TIGR00336; pyrE; 1.
DR   PANTHER; PTHR46683; OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED; 1.
DR   PANTHER; PTHR46683:SF1; OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED; 1.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; PRTase-like; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000313|EMBL:EXJ57992.1};
KW   Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019473};
KW   Transferase {ECO:0000313|EMBL:EXJ57992.1}.
FT   DOMAIN          85..185
FT                   /note="Phosphoribosyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00156"
SQ   SEQUENCE   245 AA;  26130 MW;  7D55FC3A538B9E5B CRC64;
     MATTTSYKDT LLPLLLKAKV LSFGTYTLKS GRVSPYFFTS TLLHTASLLG ALARGFAAVL
     TSPPFSLPLG TEEAGSDADG SLSPHFDIIF GPAYKGIPLA AIVARELEFG GHNFEGVSYA
     FNRKEAKDHG EGGIIVGAPL KGKRIIILDD VMTAGTALRE AVSIIKAQGG TVVGVVLLLT
     RQERVSDTEP RSAMKVAEDE LGVPVRAVLK FEDLLEGIET GKIEGAGPEQ LELMRTYREK
     YGSTD
//