ID W9VW46_9EURO Unreviewed; 489 AA.
AC W9VW46;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=NAD-dependent aldehyde dehydrogenase {ECO:0000313|EMBL:EXJ59878.1};
GN ORFNames=A1O7_04025 {ECO:0000313|EMBL:EXJ59878.1};
OS Cladophialophora yegresii CBS 114405.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=1182544 {ECO:0000313|EMBL:EXJ59878.1, ECO:0000313|Proteomes:UP000019473};
RN [1] {ECO:0000313|EMBL:EXJ59878.1, ECO:0000313|Proteomes:UP000019473}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 114405 {ECO:0000313|EMBL:EXJ59878.1,
RC ECO:0000313|Proteomes:UP000019473};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora yegresii CBS 114405.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024149};
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ59878.1}.
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DR EMBL; AMGW01000003; EXJ59878.1; -; Genomic_DNA.
DR RefSeq; XP_007756231.1; XM_007758041.1.
DR AlphaFoldDB; W9VW46; -.
DR STRING; 1182544.W9VW46; -.
DR GeneID; 19178616; -.
DR VEuPathDB; FungiDB:A1O7_04025; -.
DR eggNOG; KOG2450; Eukaryota.
DR HOGENOM; CLU_005391_0_2_1; -.
DR OrthoDB; 216092at2759; -.
DR Proteomes; UP000019473; Unassembled WGS sequence.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07106; ALDH_AldA-AAD23400; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR044086; LUC3-like.
DR PANTHER; PTHR11699:SF263; ALDEHYDE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000019473}.
FT DOMAIN 34..483
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 261
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 489 AA; 53303 MW; 7FE581324A2A9FA7 CRC64;
MAPHATENGA ANGASTAGLD FTTFSNVIDG KLSSTQKTRH GINPATGKPN YEVPVSAPED
VDRAMAAAKR ACKPWAKTPY AERQKAVNAF ADALEQEKDG FAKLLTQEQG KPLHFAYFEL
DFTLQIIRTM ASLELPTEEI VDEAERKILV RYTPLGVTVG IAPWNYPVLL CCSKIAPCVV
TGNPIIIKPS PFTPYGGLKV VELAQRFFPP GVVQALSGDD NLGPWLTAHP TPAKVSFTGS
SATGKKVMES CSRTLKRVTL ELGGNDPAVV LDDVNIDEVA PKIATLAFLN SGQICLALKR
IFVHEKIYEQ FRDKMVEYTK TLKVGEGFEK DVFLGPIQNS MQYERVKGFF EAIDKEKYEV
AVGGKNPDGP GYFITPTIID RPKEDSRIVV EEPFGPIVPL LTFSTDEEAI EKANNTPYGL
GASVWSGDIE RAAKVAQELE AGSVWVNTHF ELDPRAPFGG FKESGIGTEF GVGGLKSYCN
SQTLYLKKK
//
