ID W9WPY7_9EURO Unreviewed; 692 AA.
AC W9WPY7;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA {ECO:0000313|EMBL:EXJ70247.1};
GN ORFNames=A1O5_06315 {ECO:0000313|EMBL:EXJ70247.1};
OS Cladophialophora psammophila CBS 110553.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=1182543 {ECO:0000313|EMBL:EXJ70247.1, ECO:0000313|Proteomes:UP000019471};
RN [1] {ECO:0000313|EMBL:EXJ70247.1, ECO:0000313|Proteomes:UP000019471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 110553 {ECO:0000313|EMBL:EXJ70247.1,
RC ECO:0000313|Proteomes:UP000019471};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora psammophila CBS 110553.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the 5-carboxymethylaminomethyl modification
CC (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
CC {ECO:0000256|ARBA:ARBA00002739}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the MnmG family.
CC {ECO:0000256|ARBA:ARBA00007653}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ70247.1}.
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DR EMBL; AMGX01000009; EXJ70247.1; -; Genomic_DNA.
DR RefSeq; XP_007745099.1; XM_007746909.1.
DR AlphaFoldDB; W9WPY7; -.
DR STRING; 1182543.W9WPY7; -.
DR GeneID; 19191026; -.
DR eggNOG; KOG2311; Eukaryota.
DR HOGENOM; CLU_007831_2_2_1; -.
DR OrthoDB; 5486689at2759; -.
DR Proteomes; UP000019471; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 1.10.150.570; GidA associated domain, C-terminal subdomain; 1.
DR HAMAP; MF_00129; MnmG_GidA; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR049312; GIDA_C_N.
DR InterPro; IPR004416; MnmG.
DR InterPro; IPR002218; MnmG-rel.
DR InterPro; IPR020595; MnmG-rel_CS.
DR InterPro; IPR026904; MnmG_C.
DR InterPro; IPR047001; MnmG_C_subdom.
DR InterPro; IPR044920; MnmG_C_subdom_sf.
DR InterPro; IPR040131; MnmG_N.
DR NCBIfam; TIGR00136; gidA; 1.
DR PANTHER; PTHR11806; GLUCOSE INHIBITED DIVISION PROTEIN A; 1.
DR PANTHER; PTHR11806:SF0; PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL; 1.
DR Pfam; PF01134; GIDA; 1.
DR Pfam; PF13932; GIDA_C; 1.
DR Pfam; PF21680; GIDA_C_1st; 1.
DR SMART; SM01228; GIDA_assoc_3; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS01280; GIDA_1; 1.
DR PROSITE; PS01281; GIDA_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Reference proteome {ECO:0000313|Proteomes:UP000019471}.
FT DOMAIN 591..662
FT /note="tRNA uridine 5-carboxymethylaminomethyl modification
FT enzyme C-terminal subdomain"
FT /evidence="ECO:0000259|SMART:SM01228"
SQ SEQUENCE 692 AA; 75822 MW; 5F79EBF82EC9774A CRC64;
MRSVLRQSSP FQWGHTPRTR SCILLRQRRF FAAVADAVKP YDVVVIGGGH AGTEASAAAA
RSGARTALVT PSLSNLGVCS CNPSFGGIGK GTMIREIDAL DGVAGRIIDK AGIQFRMLNI
KKGPAVWGPR AQIDRDLYKK YMREEMLSTP NLSILEGKVA DIIVSRENID AGDKISQGRI
TGIRLEDGQV IPASHVVITT GTFLGGEIHI GLEAYPSGRM GEAATFGLSQ SLRSAGFTLG
RLKTGTPPRL DRDTIDFSVL QVQPGDSPPT PFSYLNNTVE IGDAGQLNCW TTYTNEASHE
IIRANLDKSI HIRETVKGPR YCPSLESKII KFKDKQRHMI WLEPEGLEPN TIIYPNGISM
TVPADAQYAM LRTVKGLENV KMLQPGYGVE YDYIDPRNLF PTLETKLIKG LFLAGQINGT
TGYEEAAAQG IVAGINAGLS AQGKGPFTLS RAEAFIGILI DDLITKGVSE PYRMFTARSE
YRMSCRSDNA DLRLTEKGRE VGVVSDRRWA HFTSTRDQMA ELQSKLEEVQ YPSTEWVKMG
FPSRIDSNRR SAFDMLRVTG VDMKSIADRV QSLPSISNYS SKVQNRVQIE SLYAPYISFQ
QKAAESFARD ESLALPADLD YDSVFGLSIG EREVLKLVRP ASVGMARRVE GVTPHGALRL
LKYAKKNGRS KMPEGELMLQ GDSARLGGAI AV
//
