ID W9WTP4_9EURO Unreviewed; 317 AA.
AC W9WTP4;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Methylisocitrate lyase {ECO:0000313|EMBL:EXJ68016.1};
GN ORFNames=A1O5_08631 {ECO:0000313|EMBL:EXJ68016.1};
OS Cladophialophora psammophila CBS 110553.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=1182543 {ECO:0000313|EMBL:EXJ68016.1, ECO:0000313|Proteomes:UP000019471};
RN [1] {ECO:0000313|EMBL:EXJ68016.1, ECO:0000313|Proteomes:UP000019471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 110553 {ECO:0000313|EMBL:EXJ68016.1,
RC ECO:0000313|Proteomes:UP000019471};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora psammophila CBS 110553.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate +
CC succinate; Xref=Rhea:RHEA:16809, ChEBI:CHEBI:15361,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:57429; EC=4.1.3.30;
CC Evidence={ECO:0000256|ARBA:ARBA00001050};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ68016.1}.
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DR EMBL; AMGX01000014; EXJ68016.1; -; Genomic_DNA.
DR RefSeq; XP_007747402.1; XM_007749212.1.
DR AlphaFoldDB; W9WTP4; -.
DR STRING; 1182543.W9WTP4; -.
DR GeneID; 19193329; -.
DR eggNOG; KOG1260; Eukaryota.
DR HOGENOM; CLU_027389_3_0_1; -.
DR OrthoDB; 554215at2759; -.
DR Proteomes; UP000019471; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00377; ICL_PEPM; 1.
DR Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1.
DR InterPro; IPR039556; ICL/PEPM.
DR InterPro; IPR018523; Isocitrate_lyase_ph_CS.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR PANTHER; PTHR42905; PHOSPHOENOLPYRUVATE CARBOXYLASE; 1.
DR PANTHER; PTHR42905:SF2; PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN; 1.
DR Pfam; PF13714; PEP_mutase; 1.
DR SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
DR PROSITE; PS00161; ISOCITRATE_LYASE; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:EXJ68016.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019471}.
SQ SEQUENCE 317 AA; 33412 MW; 7E5660A8E70C61D9 CRC64;
MSSITAPNKY TGQSAAARLR CLLDEEGKTI FCPGVYDGIS ARLALNTGFN CLYMTGAGTA
ASMLGMPDLG LATMNDMVQN ASMIASLDRS VPVIADADTG YGGPGSVART VKAYIAGGVA
GMHLEDQVQT KRCGHLANKE LVDDVYLSRV RAAVLAQEEM RRVTGGFADI VIIARTDSLQ
SLGYEVAVSR LRKAIAAGAD VGFLGGMTTM DQCSRACKDL SPTPVLLNMV AGGITPDLSV
EEANRLGYKI VIFPAVALGP VSEVVEAAMK DLKQNQRARV SQAQREGGVK QFFNLLGQQE
CMEFDKRAGG VAFADGA
//
