ID W9WXJ3_9EURO Unreviewed; 1252 AA.
AC W9WXJ3;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=HECT domain-containing protein {ECO:0000259|PROSITE:PS50237};
GN ORFNames=A1O5_03835 {ECO:0000313|EMBL:EXJ72688.1};
OS Cladophialophora psammophila CBS 110553.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=1182543 {ECO:0000313|EMBL:EXJ72688.1, ECO:0000313|Proteomes:UP000019471};
RN [1] {ECO:0000313|EMBL:EXJ72688.1, ECO:0000313|Proteomes:UP000019471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 110553 {ECO:0000313|EMBL:EXJ72688.1,
RC ECO:0000313|Proteomes:UP000019471};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora psammophila CBS 110553.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ72688.1}.
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DR EMBL; AMGX01000005; EXJ72688.1; -; Genomic_DNA.
DR RefSeq; XP_007742635.1; XM_007744445.1.
DR AlphaFoldDB; W9WXJ3; -.
DR STRING; 1182543.W9WXJ3; -.
DR GeneID; 19188562; -.
DR eggNOG; KOG0941; Eukaryota.
DR HOGENOM; CLU_001858_0_0_1; -.
DR OrthoDB; 1820836at2759; -.
DR Proteomes; UP000019471; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 6.10.130.10; Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL); 1.
DR InterPro; IPR032353; AZUL.
DR InterPro; IPR042556; AZUL_sf.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700:SF8; HECT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF16558; AZUL; 1.
DR Pfam; PF00632; HECT; 2.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000019471};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 842..1252
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1001..1023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1043
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1220
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1252 AA; 142113 MW; D89D11EDA395B365 CRC64;
MHFTKHGSKA ATLDDSSHEG TDKQPRVKAS DLGFHVPDHV LDDIIQISDP KLLYSNVHAQ
RDRRLRLLIR RYTNQIQYGC RNVNCTTPTC LSYRKRNSTG PLRKYTELSA RTLACQLVDE
YNRSGKDPFC GLCQNEPVVP WYEDPALGKK RRNSYEKVGH LRQENGHLPK PSGLAQRTKD
SPKAMPLTDN APRRISQDGV VRAGRRLREM DTSMEDELAD VLNRTVPRGS MEKVPHGEHL
ANHDLEQASA APAKQKDLAS FTQTLFDLVP LRLLNWLPAI YDCPTTGVSR PAGLPVNQKQ
ASIKTPTEGS LPPAENTEPL SGRETPEQHC ASKKPPHQPA YSLRTLTWVT LPWLRSVPRD
EEGYQWKFVP FMKQSLAYCL SDPERLVNTV KDLQDSYWTG SRKQSKQNDM NAGNGPITSP
ESDSISPWPI ISTNTRDDMQ ALLFSFAYIQ KFEQRDLVLT SILNALQNAY YLPPWLQSRR
SGKHSRSGSG SSDLALIKRR QSSDVNSSRN SRSPDSSGLD ILEEIDTPLI PLKDAQITEL
CLMALLSLAT TIFHPPDAML FSGKQHFVRL ARERNCGLAH SFWVVFKGRD LTGIREIIDV
IDICEDWTVH RLLTALMNIV SHRLTVTKWA ATLKSSGMSK SNRTTIVESL IDRFDRDYLP
GWDRFDKNSS WIGTAAIELG RTVLLKDWDR SPIIQRAGPV GGALELLAGL YRARHQLNLD
AEWFHMPFIA DIFDDMSMPS EWLSFRPDSR QMHLLSFSFL FPPEVLVQYF RAINIAIMKK
SHEDATIVYN DIRQYMWAPA IPIYGAKEVL ARLRPHMARY FVLTIRRQDV LNDAIDQIWR
RQRRELMCPL RVRLGKDEGE DGLDHGGVQQ EFFRVVFGEA LRPEYSMFTV DDTTRMTWFQ
PGSFEPLYRF EALGILMSMA IYNGITLPIT MPLAFYRKLL GLKVKKLEHI ADGWPELTKG
LKSLLDWSEG DVGEVIARTY EFSYELCGST VTVDMQKVGR HDPWPPTKPR TSKKGKEKSK
STSFELPLEP TLTPPPQPSP NLSPNIPNGS ILSRTSSIEI KGISTPLSID SDMLENSGPE
AALVTNANRE QYVKDYILWL THKSIEPQYE AFARGFYTCL DRTALSIFNP ESLKALIEGY
PDIDIDELQM TTTYDEYTSE SPTIVDFWHV VRSMSTHQHR QLLEFVTASD RVPVNGMRSL
TFIVQKNGEE DNRLPSSSTC YGRLLLPQYS SRAVMEEKLT KAIENCVGFG TL
//
