ID W9X546_9EURO Unreviewed; 855 AA.
AC W9X546;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN ORFNames=A1O7_01920 {ECO:0000313|EMBL:EXJ65579.1};
OS Cladophialophora yegresii CBS 114405.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=1182544 {ECO:0000313|EMBL:EXJ65579.1, ECO:0000313|Proteomes:UP000019473};
RN [1] {ECO:0000313|EMBL:EXJ65579.1, ECO:0000313|Proteomes:UP000019473}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 114405 {ECO:0000313|EMBL:EXJ65579.1,
RC ECO:0000313|Proteomes:UP000019473};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora yegresii CBS 114405.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000256|ARBA:ARBA00010992}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ65579.1}.
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DR EMBL; AMGW01000001; EXJ65579.1; -; Genomic_DNA.
DR RefSeq; XP_007754146.1; XM_007755956.1.
DR AlphaFoldDB; W9X546; -.
DR GeneID; 19176531; -.
DR VEuPathDB; FungiDB:A1O7_01920; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_333991_0_0_1; -.
DR OrthoDB; 5319980at2759; -.
DR Proteomes; UP000019473; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR NCBIfam; TIGR00879; SP; 1.
DR PANTHER; PTHR48022:SF38; MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR48022; PLASTIDIC GLUCOSE TRANSPORTER 4; 1.
DR Pfam; PF12697; Abhydrolase_6; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019473};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..468
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 855 AA; 94533 MW; 79AF78E727151354 CRC64;
METATNYNFL IVLIVTFGSL TYGYNSAIIG AVIGLPSFFQ YFNIDIKSGD VLGHVGADTT
LTFLSATNGL FAGGGFIGCY LITWLADKVG RKRSIQITSC LCIVAGALQA GSVHIAMFLV
ARFLMGMGVG MVNVITPLYQ SEVSPAHSRG RMVGSHGFVL CVGYGLAGWT GYGCYFLESQ
VAQWRLCLAL QVVPPLGLLI GSWWVPESPR HLVATDQQEA GFAILKRLHH QPDDEDDTVA
REELYQIRLQ LDLEKRQGWR QGWLKGWISL FTRKSYRKRL LFGFLLLGLV QSTGCLVIDN
YQVLLYNGLS LYGAMPLMLY ALWDTWAAIM NLVNALLLDK IGRIPIMVVG QIGCSVSVAG
FTACLARYGG TENRVGNGFG VFFLYLFVTF FGGSMDASSY VYSSEIFPTS IRAQGAGFSV
SGLFAFSLIY TMCAPVAFNN IGWKYYLIFI IVPLFGATIM YLFYPETKGL ALEEIAAKFG
DEVAVNITDL SAEERARLGK SLVNTDIIEL EMKQAAPTIT IRKNNPWETK SEISGLIPLP
ERDVSLFAHA SGPPRLQGEP VVILFTGAGG PAATYVKVQE HLSSFARTLF YDRAGYDRST
LPSNVESLMA HDAAHDLDAL LGKIDVPPPY ILIGHSYGGV PLREFLHLQL AKHRPSNPLA
VVGGIVLYDT GTEAEYAFWP RLPSADLVAV CKDVDWEGLT HLREESGMTD DEWASAMEAS
RRMATKLATK REDTHASARS LAERRQLEHH AYRGDNVAVI RCNSARDYRI GYEEGVRLGG
GTEDERRGAK KFIEDWSLYT YGMVKVQVDL VGQHGNALYQ ELMDWGHDSP FRKPELVGDA
VEWVLNELRK QKESH
//
