ID W9XUQ1_9EURO Unreviewed; 1511 AA.
AC W9XUQ1;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
GN ORFNames=A1O5_02278 {ECO:0000313|EMBL:EXJ73984.1};
OS Cladophialophora psammophila CBS 110553.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=1182543 {ECO:0000313|EMBL:EXJ73984.1, ECO:0000313|Proteomes:UP000019471};
RN [1] {ECO:0000313|EMBL:EXJ73984.1, ECO:0000313|Proteomes:UP000019471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 110553 {ECO:0000313|EMBL:EXJ73984.1,
RC ECO:0000313|Proteomes:UP000019471};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora psammophila CBS 110553.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000256|ARBA:ARBA00008251}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ73984.1}.
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DR EMBL; AMGX01000003; EXJ73984.1; -; Genomic_DNA.
DR RefSeq; XP_007741084.1; XM_007742894.1.
DR STRING; 1182543.W9XUQ1; -.
DR GeneID; 19187011; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000019471; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 2.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000019471};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..1511
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004934835"
FT TRANSMEM 1364..1385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..680
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 716..1353
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 1511 AA; 169433 MW; 40A369D3ED423121 CRC64;
MIIRSYCRRA VVSSVALLLL LASSPQPTQA KKDGPTISST TFDNPLENVF YFDDSDVVIG
YDGETGIVWR SADAGETWKE INDQGQSGNA LDVYRHPYDN QRAYIIGLDS DHWVTTDAGE
TWRKFSSDGD GLARFRNAPL SFHGRDPKRV IWNAEHCVGL ACIERAFYTD DDFKTTNRLG
DMTRGCQWAV STPDFGEEIA PEIRDRIFCI VEGLYSPWPK DNRLLVSDDF FDRDQVEPAL
DDGRAVTGII SMAAVKGFLV AAAKSEGTDE LALYVTKDAS QWHRAEFGQH RIDEDAYTIL
ESTNYSLQVD VLGSRPTNPM GYLFTSNSNG TYFTRNIDHT NRNIFGNVDF EKVQAIQGIV
LVNVVDNWKD VEGSTIPRKE VISQISFDDG RTFQDLKVGD KRLHLHSVTD ARQTGRIFSS
PAPGIVMGIG NTGKFLKDYE DGDLYVSDNA GVTWYEGLDG AYLYEFGNQG AVIVAVDDED
STGHIRYSID HGKTWKKADL GEKVRARFLT TVPDSTTLKF LMMGAKGTGS KTEWVMFKID
FEGLHERACG KDDFERWPAR VDKDGKPSCL MGHKQFYRRR KADADCFIDE EFKDPVPEFE
PCVCTMADFE CDYNFVRDPD DRTKCNPAQP IAVPEGACKN EKDTFKGPSG WRMIPGNECL
RKGGEELDKE IERPCSDSVK TPASGRITVE KTNFNADRFS EWYYLGGSGT SKGNDETIVM
RTSEQDIFLS RDHGKTWERI LKGEPITAIA PNPHHHDSVF FLTGSKTVHY TIDRGDRFDK
FTAPERPSTL RLPTLRFHSE YKDWLLWSGS VGNDDHTNIW LSRDRGDHWD TLVRYARKCE
FITRESQGRG NQLIYCEQYQ DENPDKNLML LSSDNFFAES KVHFPDILDF ATMSEFIIVA
AKTEDRQSLK VDASVDGRTF APAEFPRNFQ VKHQQAYTVL DSSTHAVFLH VTVNAVQDHE
YGAIIKSNSN GTSYVFTLGG VNRDTEGYVD FEKMQGLEGV AMVNVVSNID ETNNGERKKL
KSMITHNDGA QWAYFPPPKE DALGNNYPCV EEANKATEKC SLHIHSYTER ADKSATFSSP
SAVGLMMAVG NVGEYLARKD DEATDTFITR DAGITWQSVK KGSYMWEYGD QGSIIVIVKE
SQPTKSLFYT LDEGKTWREF VFSPDVEMQI DAITTVPSDN SRNFLLWGRE LGTTAKRGIF
TVHLDFSGLE ERQIKCDLDE KNPEKGDYAL WEPKHPMQDS NCLFGHVAQY HRKRVDAKCY
NGKVISHVHN IARNCSCTRQ DFECDYNYQA QADGTCQLVP GLQPADHEQN CRDNPNQLEF
WYPTGYRRIP LTTCQGGREL DKLESRPCPG HEKEYKKKHG ISGVALFFAI VIPITVALGI
GYWVYTQWRS GFGSFGQIRL GESMGATGTS SGASGDPLWI KIPVAVVSGV VAVAKATPLL
VMSLWRSAKG YMPLGSGGAS GGRFGAGRGT DAGYGAPYRS RDAFARRGQD YSQVVEDDEL
LGDGLDDEEE V
//
