ID W9ZBR5_9EURO Unreviewed; 1339 AA.
AC W9ZBR5;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN ORFNames=A1O3_00499 {ECO:0000313|EMBL:EXJ91949.1};
OS Capronia epimyces CBS 606.96.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Capronia.
OX NCBI_TaxID=1182542 {ECO:0000313|EMBL:EXJ91949.1, ECO:0000313|Proteomes:UP000019478};
RN [1] {ECO:0000313|EMBL:EXJ91949.1, ECO:0000313|Proteomes:UP000019478}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 606.96 {ECO:0000313|EMBL:EXJ91949.1,
RC ECO:0000313|Proteomes:UP000019478};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capronia epimyces CBS 606.96.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC ECO:0000256|RuleBase:RU363098};
CC -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC ECO:0000256|RuleBase:RU363098}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ91949.1}.
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DR EMBL; AMGY01000001; EXJ91949.1; -; Genomic_DNA.
DR RefSeq; XP_007728839.1; XM_007730649.1.
DR STRING; 1182542.W9ZBR5; -.
DR GeneID; 19164639; -.
DR eggNOG; KOG0988; Eukaryota.
DR HOGENOM; CLU_002322_0_1_1; -.
DR OrthoDB; 2735303at2759; -.
DR Proteomes; UP000019478; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR PANTHER; PTHR23079:SF14; RNA-DEPENDENT RNA POLYMERASE; 1.
DR Pfam; PF05183; RdRP; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW Reference proteome {ECO:0000313|Proteomes:UP000019478};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000256|RuleBase:RU363098};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
FT REGION 147..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1315..1339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1316..1339
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1339 AA; 151997 MW; 1E95C8044279474C CRC64;
MHTPQHVGWK VDKAINDLNA QWDLGLPRLH GREADTAEAK GPLATKCSSI IRFLCFRTDK
IDHILAGFEE HARKKYSRWR WKPSQERGTL PTLPVTKSLL ASDVQTKREA GLIRLSDPQR
QELLQLLYDV LDEPFQLAKM SESFSYERPP SFLTAPSTPR KESSTREVAT PSRQILQSMD
SLTSHADEPQ VKDPTRKSSK RSLGSPEGKN KRQMTLSEFP FQRNRDASPL WLRPLLQPDP
ISFETVPSAR VSSVFTTTDE GHDPCTSNET SMMSSVSDCS QNLFPTQDYH DLMDDEEFNT
SFNEACEVPK PVDPLDLAQY TPFKRSALLP SDVPFWYCWE IHRVASVVGL VPIDVYKAVR
KSVRQTNPPY EEVWKALRQL CHEKAGKTVP KSELANWTTA ENQYENPQHQ LQKGVYLTGN
LDWNDDGSQG LFSFRLNEIH QEQSCRLHRK FGADRFLVIS APDFSRFPKQ IRQADEEMVH
EGLTEFLATG SHFIAGRYWR VFWIEPEKNK KKKKGREQLP RLKIHLFAEQ GYDIVSRNSE
HLNIANLKDD GRHRELTIED LTEWHMPIRA NIRSTNLKLF SRWAIVLSKT VPTTVLKQKE
FLYLHDPPGA VVMNDGCARM SYALAKDIWA KYGGAGDVPS AVQGRIGGAK GLWLVDYSDA
FRGVSDRQYW IQVSDSQLKV KPHPRDRSDA DESQRTFEVL KFAGDSKPAH LNMQLITILE
DRGVSRHTLQ AQLEADTRSY FESLKAAMAD PKALRLWMQE YGLASRPEVR KVVGSFPIDH
REQMKRLLEA GFHPQECVRL KELAAGFLRD YMTNYVEKLW INVPCSTVVF CAPDPLGVLE
EDEVCLNFSS PVTDPRRDYP ETTLDGLEVL VARNPAYLAS DMQLRKAVYH HELRHYKNII
LFPVKGKQPL ASLLSGGDYD GDTVTVIWDP AIVKDFQNTM PPDLPKEEQC GMVQESQPLS
SIFDGIRRPE EAMRESLRGC ISFNARPSLM GVCSSEHEKL IYSLSLKRVG GKLSNPGALK
LAALAGYLVD SNKQGWSLKR QAFYLLRRDA SGLHRLPDPA FKGDKAPSRA SGTYLNIIDF
LKFEVAEGCK TLALREFKEL CPATRPYDGV LSETWRKAET KADQEKTPPA VLPVKSGRIS
RNMLTGPQAP VGGLKEILLG PDGLLKQIDE LRKMAAKLAA IRKSISSTPA NPSDRKKFHV
EVQALFERYQ QIEPKQVDHE LRRRFENERD HPFPYWSLLR ASCLHRRACG NGGFPVWVWY
VAGRELCILK TLHHPGEVRL VTAEMHNILK VDSKFTKGLL EGSVSETGEV FYDAVDEPNV
GDDDDDDDDD DVDDYAFEA
//
