ID WDR44_XENLA Reviewed; 912 AA.
AC Q498F0;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=WD repeat-containing protein 44;
GN Name=wdr44;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Downstream effector for rab11 (By similarity). May be
CC involved in vesicle recycling (By similarity). May also be involved in
CC the inhibition of the intracellular ciliogenesis pathway (By
CC similarity). {ECO:0000250|UniProtKB:Q5JSH3,
CC ECO:0000250|UniProtKB:Q9R037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q9R037}. Cytoplasm, perinuclear region
CC {ECO:0000250|UniProtKB:Q9R037}. Endosome membrane
CC {ECO:0000250|UniProtKB:Q9R037}. Golgi apparatus, trans-Golgi network
CC {ECO:0000250|UniProtKB:Q9R037}.
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DR EMBL; BC100241; AAI00242.1; -; mRNA.
DR RefSeq; NP_001089666.1; NM_001096197.1.
DR AlphaFoldDB; Q498F0; -.
DR SMR; Q498F0; -.
DR BioGRID; 592507; 1.
DR IntAct; Q498F0; 1.
DR GeneID; 734726; -.
DR KEGG; xla:734726; -.
DR AGR; Xenbase:XB-GENE-6255294; -.
DR CTD; 734726; -.
DR Xenbase; XB-GENE-6255294; wdr44.L.
DR OMA; QRTHEYL; -.
DR OrthoDB; 11918at2759; -.
DR Proteomes; UP000186698; Chromosome 8L.
DR Bgee; 734726; Expressed in zone of skin and 19 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR040324; WDR44/Dgr2.
DR PANTHER; PTHR14221; WD REPEAT DOMAIN 44; 1.
DR PANTHER; PTHR14221:SF0; WD REPEAT-CONTAINING PROTEIN 44; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Endosome; Golgi apparatus; Membrane; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..912
FT /note="WD repeat-containing protein 44"
FT /id="PRO_0000262772"
FT REPEAT 511..550
FT /note="WD 1"
FT REPEAT 608..646
FT /note="WD 2"
FT REPEAT 648..688
FT /note="WD 3"
FT REPEAT 693..732
FT /note="WD 4"
FT REPEAT 743..782
FT /note="WD 5"
FT REPEAT 787..826
FT /note="WD 6"
FT REPEAT 841..880
FT /note="WD 7"
FT REPEAT 882..912
FT /note="WD 8"
FT REGION 206..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..257
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 912 AA; 101686 MW; 33E1603E50B16ED7 CRC64;
MASDSDTEEF FDAPEDVNLS CSPAVSPLKS ETFILKEEAT YSKKAETRNI ELKQDDSKEI
IDSIIEESQK CSDTENENPV VEEKTEVLHE TLIGDSVKTK QDLLSNIPEL VVTESTFHDG
VEDPLQQQIS EYLEPDISRS QDAGPSADSA YVPSAIENIV DLTQDLKITE ELKIAEEPEI
PLIQEETKDP SKNIVEDVFS KLPTSDIIEQ LPPAKPPRQI CVEPDIVAST KKSGPNRPPQ
PINAPPPRPP PPARPAPPPR KKKGDTDFDR SSGFEYQKDG FLAGGLLSPN TLTENMNRDS
QPSLDLASAT SGEKIVTAQE NGKAADGQLS SQSSECLGPQ RPRSNSGREL TDDEILASVM
IKNLDTGEEI PLSLAEEKLP TGINPLTLYI MRRTKEYVSN DAAQSDDEEK PQSHQSETDG
GKLKQKTTQL KKFLGKSVKR AKHLAEEYGE RAVNKVKSVR DEVFHTDQDD PSSSDDEGMP
YTRPVKFKAA HGFKGPYDFE QIKVVQDLSG EHVGAVWTMK FSHCGRLLAS AGQDNVVRIW
VLKNAFDYFN NMRIKYNTEG RVSPSPSQES LNSSKSDTDG GVFSGTDDVD PDDKNAPFRQ
VPFCKYKGHT ADLLDLSWSK NYFLLSSSMD KTVRLWHISR RECLCCFQHI DFVTAIAFHP
RDDRYFLSGS LDGKLRLWNI PDKKVALWNE IDGQTKLITA ANFCQNGKHA VIGTYDGRCI
FYDTEHLKYH TQIHVRSTRG RNRVGRKITG IEPLPGENKI LVTSNDSRIR LYDLRDLSLS
MKYKGCVNSS SQIKASFSHD FTYIVSGSED KYVYIWSTYH DLSKFTSVRR DRNDFWEGIK
AHNAVVTSAI FAPNPGLMVS AETSSEKQEG DQAEPVENIP SGALKSDHTE VLLSADFTGA
IKVFINKKKN IS
//
