ID X0BW51_FUSOX Unreviewed; 941 AA.
AC X0BW51;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Ras guanine nucleotide exchange factor A {ECO:0008006|Google:ProtNLM};
GN ORFNames=FOMG_01741 {ECO:0000313|EMBL:EXK49076.1};
OS Fusarium oxysporum f. sp. melonis 26406.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=1089452 {ECO:0000313|EMBL:EXK49076.1};
RN [1] {ECO:0000313|EMBL:EXK49076.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=26406 {ECO:0000313|EMBL:EXK49076.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Gale L.R., Schwartz D.C., Zhou S., Corby-Kistler H., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusarium oxysporum melonis.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EXK49076.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=26406 {ECO:0000313|EMBL:EXK49076.1};
RG The Broad Institute Genomics Platform;
RA Ma L.-J., Corby-Kistler H., Broz K., Gale L.R., Jonkers W., O'Donnell K.,
RA Ploetz R., Steinberg C., Schwartz D.C., VanEtten H., Zhou S., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "Annotation of the Genome Sequence of Fusarium oxysporum f. sp. melonis
RT 26406.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; JH659329; EXK49076.1; -; Genomic_DNA.
DR AlphaFoldDB; X0BW51; -.
DR VEuPathDB; FungiDB:FOMG_01741; -.
DR Proteomes; UP000030703; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 459..585
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 686..924
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 941 AA; 105186 MW; B32A77EFA63A1ED5 CRC64;
MQPNHVDSQN AHPTSGIAAS GPASIDPDIE SDSDPLAPAN GHRDSVGSII DDPFFQTYDP
AVQAAAVSED EDQSDGSSVY QSLEDEDHEH LFHDTKGHNF GKAAKQAKRK SGGGKKLKPD
SDDNEPSQYW PPPRRESLTA TPSSYWSQAS PTMESFNIAV IGSTGVGKSS FVQRVLGLSR
PPISNASSVR MLVDNNSHAV TLLELDLEYF ELNPTQPIQW PKQINGHIVP RVDAALILYD
VTNHESVREL PQTLAALTNS GLPASLVACK CETPEAEWQV NAEAIANHQL FKSCVSTYKI
SSNDTDVAKT CLHTILRAAI AHRREENGET FSRRRAQSAA NLEAPDVGTG RPISQHSKHS
RASSDFSLLK GFSNPPINEN YRAQSSRSPR QGHIASSNPE AGEMGQAQTL NNMLRTPGIR
LDRPSTDSFL DVDESDAESY RYSDDIPILQ RNDDNTLDKQ SKMAGVTFDE LVDRLLAPRL
TRIDNNFSDV FLCLYRKFAA PGELFTAILT RLDKVRDDKT AHYLSKTATQ LRIIEVVAKW
VSLYPGDFAR PQTRRNLEEF IRHLSTEPIF SIAAQHMRRH LQFNVVEDDD TGWANSDEAS
DKLASEILSK DMNELSSGVS VLTVESDMDG RPSGSSEVSL ADRSSSVSSQ VHFHTFEDYE
RAASNLEPTD NLPMNKFRYH IFMDIPDDDV ADELTRIDWI MFSSIRIRDF VRHVSLSASQ
KERCKSLRNV NRMINHFNHV AKWVANMILL RDKAKHRALI LEKFMNISLK LRQLNNYNGL
AAILAGVNGT AIHRLNQTRT LVPAEVQKRF ARLGILMGTQ KSHFAYRLAW ENSSLPRIPF
IPLHRRDLVS AEEGSRTFVG TDGDRINWKK FEVLGEVLLP IMKSQSTSYP NLTKHDTARE
LILGCRMPTD EEDIYQRSVQ VESGSGGFAE PPKKKFPWFA K
//
